Results 181 to 190 of about 10,493,362 (203)

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Meaningful Mediation Analysis: Plausible Causal Inference and Informative Communication

Journal of Consumer Research, 2017
Statistical mediation analysis has become the technique of choice in consumer research to make causal inferences about the influence of a treatment on an outcome via one or more mediators.
Rik Pieters
exaly   +2 more sources

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Statistical Mediation Analysis for Models With a Binary Mediator and a Binary Outcome: The Differences Between Causal and Traditional Mediation Analysis

Prevention Science, 2023
Heather L Smyth, Matthew J Valente, Judith J M Rijnhart   +2 more
exaly  

A Practical Guide to Causal Mediation Analysis: Illustration With a Comprehensive College Transition Program and Nonprogram Peer and Faculty Interactions

Frontiers in Education, 2022
Elizabeth S Park, Minjeong Jeon, Adrianna Kezar   +2 more
exaly  

Causal Mediation Analysis in Instrumental-Variables Regressions

The Stata Journal, 2020
Stephan Heblich, Christian Dippel
exaly  

Semiparametric Estimation for Causal Mediation Analysis With Multiple Causally Ordered Mediators

Journal of the Royal Statistical Society Series B: Statistical Methodology, 2022
Xiang Zhou
exaly  

Large-Scale Hypothesis Testing for Causal Mediation Effects With Applications in Genome-Wide Epigenetic Studies

Journal of the American Statistical Association, 2022
Joel Schwartz, Xihong Lin, Andrea Baccarelli   +2 more
exaly  

Causal Mediation Analysis With a Binary Mediator: The Influence of the Estimation Approach and Causal Contrast

Structural Equation Modeling, 2023
Jos W R Twisk, Judith J M Rijnhart, Martijn W Heymans   +2 more
exaly