Results 51 to 60 of about 1,644,838 (299)

Causal associations between sleep traits and four cardiac diseases: a Mendelian randomization study

ESC Heart Failure, 2022
Aims Previous studies investigated the associations between sleep traits and cardiac diseases, but the evidence for the causal inferences was unclear.
Yongli Yang, Jingwen Fan, Xuezhong Shi, Yuping Wang, Chaojun Yang, Jiao Lian, Nana Wang, Chenyu Zhao, Yang Zhao, Xiaocan Jia   +9 more
doaj   +1 more source

Exploring Causal Relationships with Streaming Features [PDF]

The Computer Journal, 2012
Causal discovery is highly desirable in science and technology. In this paper, we study a new research problem of discovery of causal relationships in the context of streaming features, where the features steam in one by one. With a Bayesian network to represent causal relationships, we propose a novel algorithm called causal discovery from streaming ...
K. Yu, X. Wu, W. Ding, H. Wang
openaire   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Causal relationship between immune cells and obesity risk:Univariate bidirectional and multivariate Mendelian randomization study

生物医学转化
Objective This study aims to explore the causal relationship between immune cells and obesity risk using the Mendelian randomization (MR) method. Methods Data sets for 731 types of immune cells and obesity were obtained from the Genome Wide Association ...
Zhu Yun, Lin Ruifang, Liu Yongjun, Li Ya, Guo Zhihua   +4 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Association between inflammatory bowel disease and osteoporosis in European and East Asian populations: exploring causality, mediation by nutritional status, and shared genetic architecture

Frontiers in Immunology
BackgroundWhile previous research has established an association between inflammatory bowel disease (IBD) and osteoporosis (OP), the nature of this association in different populations remains unclear.ObjectiveOur study used linkage disequilibrium scores(
Jian Kang, Xize Wu, Yue Li, Shuangli Zhao, Shixuan Wang, Dongdong Yu, Dongdong Yu   +6 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Higher BMI is linked to an increased risk of heart attacks in European adults: a Mendelian randomisation study

BMC Cardiovascular Disorders, 2020
Background BMI has been implicated as a risk factor for heart disease as a whole in multiple studies. Heart attack is one of the common complications of this disease.
Benjamin Adams, Lauren Jacocks, Hui Guo
doaj   +1 more source

Semiparametric Causal Sufficient Dimension Reduction Of High Dimensional Treatments

, 2020
Cause-effect relationships are typically evaluated by comparing the outcome responses to binary treatment values, representing two arms of a hypothetical randomized controlled trial. However, in certain applications, treatments of interest are continuous
McNutt, Todd, Nabi, Razieh, Shpitser, Ilya   +2 more
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