Results 71 to 80 of about 6,601,325 (263)
Causal misspecifications in econometric models [PDF]
We bridge together the graph-theoretic and the econometric approach for defining causality in statistical models to consider model misspecification problems.
Itkonen, Juha
core
Causality between ischemic stroke and epilepsy based on Mendelian randomization
陆军军医大学学报Objective To explore the causal relationship between ischemic stroke and different types of epilepsy so as to provide genetic evidence for the risk of epilepsy after ischemic stroke.
SHU Yun, SHU Yun, YUAN Qing, WU Zhifeng
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Causal Relationship Between Endometriosis and Pelvic Inflammatory Diseases: Mendelian Randomization Study [PDF]
Kang Liu, Xiaochun Liu, Tao Cao, Xianmei Cui, Pengyu Sun, Liang Zhang, Xiaoqin Wu Department of Obstetrics and Gynecology, Shanxi Bethune Hospital & Shanxi Academy of Medical Sciences, Shanxi Bethune Hospital Affiliated to Shanxi Medical University ...
Liu X +6 more
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Unraveling the Controversy: The Causal Link Between Osteoarthritis and Alzheimer's Disease
Brain and BehaviorObjectives Research on osteoarthritis (OA) and Alzheimer's disease (AD) is currently highly controversial, and the upstream and downstream relationships between them remain unclear.
Jingkai Di +6 more
doaj +1 more source
LIQUID FUEL PRICES AND THEIR IMPACT ON FOOD INFLATION IN BULGARIA
Baltic Journal of Economic StudiesIn recent years, food inflation has become one of the major economic challenges, affecting households and economic policy across Europe. Developments in energy markets are among the factors contributing to rising food prices and have attracted ...
Lachezar Borisov
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source