Results 81 to 90 of about 1,644,838 (299)
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Decision-Theoretic Foundations for Causal Reasoning [PDF]
, 1995 We present a definition of cause and effect in terms of decision-theoretic primitives and thereby provide a principled foundation for causal reasoning. Our definition departs from the traditional view of causation in that causal assertions may vary with ...
Heckerman, D., Shachter, R.
core +4 more sources
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Causality between ischemic stroke and epilepsy based on Mendelian randomization
陆军军医大学学报Objective To explore the causal relationship between ischemic stroke and different types of epilepsy so as to provide genetic evidence for the risk of epilepsy after ischemic stroke.
SHU Yun, SHU Yun, YUAN Qing, WU Zhifeng
doaj +1 more source
NEW EVIDENCE ON THE CAUSAL LINKAGES BETWEEN FOREIGN DIRECT INVESTMENT, EXPORTS AND IMPORTS IN MALAYSIA [PDF]
By extending Wong and Tang’s (2007) study, this study aims to further explore the causal relations between FDI (foreign direct investment), exports and imports. There is a unique long-run causal relationship running from exports as well as imports to FDI.
Koi Nyen Wong, Tuck Cheong Tang
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Have Changes in State Workers’ Compensation Programs Contributed to Rising Social Security Disability Insurance Receipt? [PDF]
, 2009 During the 1990s, real outlays on Social Security Disability Insurance (DI) benefits increased nearly 70 percent whereas real Workers’ Compensation (WC) cash benefit spending fell by 12 percent.
McInerney, Melissa, Simon, Kosali
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Associations of 35 Serum and Urine Biomarkers With Vascular Dementia—A Mendelian Randomization Study
Brain and BehaviorBackground The relationship between serum and urine biomarkers with vascular dementia (VD) has been increasingly highlighted by observational studies. Yet, the causal nature underlying these associations remains elusive.
Xiaomin Zhu +8 more
doaj +1 more source
Untangling the nexus of stock price and trading volume: evidence from the Chinese stock market [PDF]
This paper explores the linear and non-linear causal relationship between stock price and trading volume in China. The empirical results substantiate that there is a long-run level equilibrium relationship between the stock price and trading volume in ...
Shyh-Wei Chen
core