Results 61 to 70 of about 1,626,990 (326)

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

A cross-tissue transcriptome-wide association study identifies new susceptibility genes for frailty

Frontiers in Genetics
Background: Although genome-wide association studies (GWAS) have identified 14 loci associated with frailty index (FI) susceptibility, the underlying causative genes and biological mechanisms remain elusive.Methods: A cross-tissue transcriptome-wide ...
Daoyi Lin, Daoyi Lin, Shuyan Wu, Wangyu Li, Peng Ye, Peng Ye, Xuan Pan, Ting Zheng, Ting Zheng, Ting Zheng, Fei Gao, Fei Gao, Fei Gao   +12 more
doaj   +1 more source

FDI and Growth: A Causal Relationship [PDF]

FDI, economic growth, causality, Toda-Yamamoto ...
Chowdhury, Abdur R., Mavrotas, George
core  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Causal Relationship Between Chronic Upper Respiratory Infections and Benign Enlargement of Subarachnoid Spaces [PDF]

, 2021
Reagan Collins
openalex   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Further properties of causal relationship: causal structure stability, new criteria for isocausality and counterexamples

, 2005
Recently ({\em Class. Quant. Grav.} {\bf 20} 625-664) the concept of {\em causal mapping} between spacetimes --essentially equivalent in this context to the {\em chronological map} one in abstract chronological spaces--, and the related notion of {\em ...
Alfonso García-Parrado, Beem J K, Berenstein D Nastase H, Bergqvist G, Bergqvist G, Christodoulou D, Flores J L, Flores J L Sánchez M, García-Parrado A, García-Parrado A, Garfinkle D, Harris S G, Harris S G, Hawking S W, Hubeny V E, Hubeny V E, Kronheimer E H, Marolf D, Marolf D, Miguel Sánchez, O'Neill, Park J C, Petrov A Z, Plebański J F, Senovilla J M M, Senovilla J M M, Stephani H, Sánchez M, Sánchez M, Sánchez M, Weinstein T   +30 more
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source