Results 101 to 110 of about 29,154 (226)

The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae [PDF]

, 2019
The Hippo pathway plays major roles in development, regeneration, and cancer. Its activity is tightly regulated by both diffusible chemical ligands and mechanical stimuli.
Bostrom, Jonathan R., Feng, Yi, Rausch, Valentina, Hansen, Carsten G., Bravo, Isabel R., Hay, David C.; id_orcid, Park, Jiwon, Link, Brian A.   +7 more
core   +1 more source

Caveolae and scaffold detection from single molecule localization microscopy data using deep learning.

PLoS ONE, 2019
Caveolae are plasma membrane invaginations whose formation requires caveolin-1 (Cav1), the adaptor protein polymerase I, and the transcript release factor (PTRF or CAVIN1). Caveolae have an important role in cell functioning, signaling, and disease.
Ismail M Khater, Stephane T Aroca-Ouellette, Fanrui Meng, Ivan Robert Nabi, Ghassan Hamarneh   +4 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin - albumin fusion. [PDF]

FEBS Open Bio
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Nopia H, Kimura M, Kurimoto D, Sato A.
europepmc   +2 more sources

Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle

The FEBS Journal, EarlyView.
EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini, Konstantinos Poalas, Margaux Versapuech, Clarisse Berlioz‐Torrent, Katy Janvier   +4 more
wiley   +1 more source

Fasting serum annexin A2 is associated with peripheral insulin sensitivity and may enhance glucose uptake via Src‐dependent signaling

Journal of Diabetes Investigation, EarlyView.
Circulating Annexin A2 is positively associated with peripheral insulin sensitivity. ABSTRACT Background and Aim Subcellular annexin A2 (ANXA2) is known to regulate membrane dynamics and GLUT4 trafficking in adipocytes; however, the role of serum ANXA2 in glucose metabolism remains unclear.
Yuichi Ito, Tsuyoshi Okura, Mari Anno, Sonoko Kitao, Satomi Endo, Yoshinori Ichihara, Tatsuya Sawano, Junichiro Miake, Etsuko Ueta, Masahiko Kato, Shin‐ichi Taniguchi, Kazuhiro Yamamoto, Takeshi Imamura   +12 more
wiley   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Central adipocyte functions in specialized caveolae

, 2006
Obesity and overweight is an increasing health problem in the world. Besides reducing quality of life obesity is a great risk factor for development of diseases such as type 2 diabetes, cardiovascular disease, and stroke. The adipose tissue is a flexible
Örtegren Kugelberg, Unn,, Degerman, Eva,   +1 more
core  

Redistribution of caveolae during mitosis

, 2011
Caveolae form a specialized platform within the plasma membrane that is crucial for an array of important biological functions, ranging from signaling to endocytosis.
Tomas Kirchhausen, Robert G. Parton, Emmanuel Boucrot, Mark T. Howes   +3 more
core   +1 more source

Expanding role of caveolae in control of adipocyte metabolism : proteomics of caveolae

, 2006
The primary function of adipose tissue is to store energy in the form of triacylglycerol, which is hydrolyzed to fatty acids to supply other tissues with energy.
Aboulaich, Nabila
core   +2 more sources

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source