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Current Opinion in Lipidology, 2001
Caveolae, cholesterol-rich invaginations of the plasma membrane, have been implicated as scaffolds where signaling complexes are assembled, and as portals to which recycling or newly synthesized free cholesterol is transported prior to efflux or redistribution.
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Caveolae, cholesterol-rich invaginations of the plasma membrane, have been implicated as scaffolds where signaling complexes are assembled, and as portals to which recycling or newly synthesized free cholesterol is transported prior to efflux or redistribution.
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The Pharmacology of Caveolae [PDF]
, 2007 Based on work in the last 15 years, caveolae are now recognized as rather complex and dynamic plasma membrane domains with important roles in cellular uptake of molecules, signal transduction, lipid homeostasis, and tumorigenesis. Functionally, caveolae orchestrate very specific events in distinct cell types, thereby making these organelles one of the ...
William V. Everson +2 more
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Comprehensive Physiology, 2015
ABSTRACTCaveolae and their coat proteins, caveolins (Cav), are cave‐like invaginations found in the plasma membrane of a variety of cells. These unique vesicles and their coat proteins, Cavs, have diverse effects on endothelial function, nitric oxide synthesis regulation, signal transduction, cholesterol metabolism, and apoptosis. Animal studies in Cav
Corey H. Mjaatvedt +3 more
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ABSTRACTCaveolae and their coat proteins, caveolins (Cav), are cave‐like invaginations found in the plasma membrane of a variety of cells. These unique vesicles and their coat proteins, Cavs, have diverse effects on endothelial function, nitric oxide synthesis regulation, signal transduction, cholesterol metabolism, and apoptosis. Animal studies in Cav
Corey H. Mjaatvedt +3 more
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2009
All blood vessels are lined by a layer of endothelial cells that help to control vascular permeability. The luminal surface of vascular endothelial cells is studded with transport vesicles called caveolae that are directly in contact with the blood and can transport molecules into and across the endothelium. The vasculature within distinct tissue types
Jan E. Schnitzer, Kerri A. Massey
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All blood vessels are lined by a layer of endothelial cells that help to control vascular permeability. The luminal surface of vascular endothelial cells is studded with transport vesicles called caveolae that are directly in contact with the blood and can transport molecules into and across the endothelium. The vasculature within distinct tissue types
Jan E. Schnitzer, Kerri A. Massey
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Caveolae and Arrhythmogenesis [PDF]
, 2008 The plasma membrane is a semipermeable barrier composed of a lipid bilayer, which defines the boundaries between the intracellular and extracellular space. However, unlike the historical model of the “fluid mosaic” for the plasma membrane, in which integral membrane proteins are evenly distributed and free to diffuse, current knowledge suggests a more ...
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Current Opinion in Cell Biology, 1996
In the past year, we have witnessed considerable progress towards an understanding of the workings of caveolae. Highlights include the identification of new caveolin family members, the characterization of VIP21-caveolin as a cholesterol-binding oligomeric protein, and evidence for functional interactions between caveolins and heterotrimeric G proteins.
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In the past year, we have witnessed considerable progress towards an understanding of the workings of caveolae. Highlights include the identification of new caveolin family members, the characterization of VIP21-caveolin as a cholesterol-binding oligomeric protein, and evidence for functional interactions between caveolins and heterotrimeric G proteins.
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Nature Cell Biology, 2001
Caveolae deliver simian virus 40 (SV40) to a new compartment called a caveosome, where the virus is sorted for transport to the smooth endoplasmic reticulum (ER). This pathway bypasses other endocytic organelles, and early steps may be shared by lipid rafts and certain glycosylphosphatidylinositol (GPI)-linked proteins.
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Caveolae deliver simian virus 40 (SV40) to a new compartment called a caveosome, where the virus is sorted for transport to the smooth endoplasmic reticulum (ER). This pathway bypasses other endocytic organelles, and early steps may be shared by lipid rafts and certain glycosylphosphatidylinositol (GPI)-linked proteins.
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Membrane microdomains and caveolae
Current Opinion in Cell Biology, 1999Glycosphingolipid- and cholesterol-enriched microdomains, or rafts, within the plasma membrane of eukaryotic cells have been implicated in many important cellular processes, such as polarized sorting of apical membrane proteins in epithelial cells and signal transduction.
Kurzchalia, T. V., Parton, RG
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Caveolae as portals of entry for microbes
Microbes and Infection, 2001Many pathogens, including many traditionally extracellular microbes, now appear capable of entry into host cells with limited loss of viability. A portal of entry shared by some bacteria, bacterial toxins, viruses and parasites are caveolae (or lipid rafts), which are involved in the import and intracellular translocation of macromolecules in host ...
Jeoung-Sook Shin, Soman N. Abraham
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Regulation of eNOS in Caveolae
2012Caveolae are a specialized subset of lipid domains that are prevalent on the plasma membrane of endothelial cells. They compartmentalize signal transduction molecules which regulate multiple endothelial functions including the production of nitric oxide (NO) by the caveolae resident enzyme endothelial NO synthase (eNOS).
Philip W. Shaul, Chieko Mineo
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