Results 61 to 70 of about 44,676 (226)

Caveolae-Specific CaMKII Signaling in the Regulation of Voltage-Dependent Calcium Channel and Cardiac Hypertrophy

Frontiers in Physiology, 2018
Cardiac hypertrophy is a major risk for the progression of heart failure; however, the underlying molecular mechanisms contributing to this process remain elusive.
Shota Tanaka, Yasushi Fujio, Hiroyuki Nakayama   +2 more
doaj   +1 more source

Post-Translational Modification and Subcellular Compartmentalization: Emerging Concepts on the Regulation and Physiopathological Relevance of RhoGTPases

Cells, 2021
Cells and tissues are continuously exposed to both chemical and physical stimuli and dynamically adapt and respond to this variety of external cues to ensure cellular homeostasis, regulated development and tissue-specific differentiation.
Inmaculada Navarro-Lérida, Miguel Sánchez-Álvarez, Miguel Ángel del Pozo   +2 more
doaj   +1 more source

Clostridium perfringens epsilon toxin induces blood brain barrier permeability via caveolae-dependent transcytosis and requires expression of MAL. [PDF]

, 2019
Clostridium perfringens epsilon toxin (ETX) is responsible for causing the economically devastating disease, enterotoxaemia, in livestock. It is well accepted that ETX causes blood brain barrier (BBB) permeability, however the mechanisms involved in this
Dobrow, Sebastian, Flores, Claudia, Linden, Jennifer R, Michel, Adam O, Schmidt, Eric F, Uzal, Francisco A, Valenzuela, Marissa, Vartanian, Timothy   +7 more
core   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Mechanism of action of Caveolae and its impact pathways

Linchuang shenzangbing zazhi
As an important component of transcellular pathway, Caveolae enables the transcellular transport of substances without disrupting cellular homeostasis. In kidney, albumin crosses glomerular filtration barrier (GFB) via Caveolae.
Xiu Du, Lin Xu, Su Cheng, Yan-ru Wang, Ming-hai Shao   +4 more
doaj   +1 more source

Caveolin1 Is Required for Th1 Cell Infiltration, but Not Tight Junction Remodeling, at the Blood-Brain Barrier in Autoimmune Neuroinflammation

Cell Reports, 2017
Lymphocytes cross vascular boundaries via either disrupted tight junctions (TJs) or caveolae to induce tissue inflammation. In the CNS, Th17 lymphocytes cross the blood-brain barrier (BBB) before Th1 cells; yet this differential crossing is poorly ...
Sarah E. Lutz, Julian R. Smith, Dae Hwan Kim, Carl V.L. Olson, Kyle Ellefsen, Jennifer M. Bates, Sunil P. Gandhi, Dritan Agalliu   +7 more
doaj   +1 more source

Avian Reovirus σB Interacts with Caveolin-1 in Lipid Rafts during Dynamin-Dependent Caveolae-Mediated Endocytosis

Viruses, 2022
Caveolin-1 (Cav-1) is the basic component of caveolae, a specialized form of lipid raft that plays an essential role in endocytic viral entry. However, the evidence of direct involvement of caveolae and Cav-1 in avian reovirus (ARV) entry remains ...
Yuyang Wang, Yangyang Zhang, Wei Zuo, Zongyi Bo, Chengcheng Zhang, Xiaorong Zhang, Yantao Wu   +6 more
doaj   +1 more source

EHD2 is a mechanotransducer connecting caveolae dynamics with gene transcription [PDF]

, 2018
Caveolae are small invaginated pits that function as dynamic mechanosensors to buffer tension variations at the plasma membrane. Here we show that under mechanical stress, the EHD2 ATPase is rapidly released from caveolae, SUMOylated, and translocated to
Alexandre Grassart, Ariotti, Bolte, Catherine Coirault, Cesar Augusto Valades-Cruz, Chan, Chen, Cheng, Christine Viaris de Lesegno, Christophe Lamaze, Cédric M. Blouin, Darius Köster, DuFort, Edelstein, Enserink, Fernández-Sánchez, Gambin, Garcia, Geiss-Friedlander, Gervásio, Goetz, Heuser, Hoernke, Iskratsch, Joshi, Kovtun, Lamaze, Lamaze, Li, Lim, Liu, Lo, Ludger Johannes, Ludwig, Morén, Nassar, Nassoy, Otsu, Palade, Paolo Pierobon, Pekar, Pierre Bost, Satish Kailasam Mani, Sheetz, Shi, Sinha, Stoeber, Stoeber, Stéphane Vassilopoulos, Stéphanie Torrino, Subramanian, Söderberg, Tolić-Nørrelykke, Valérie Chambon, Vassili Soumelis, Wei-Wei Shen, Yamada, Yang, Yeow   +58 more
core   +4 more sources

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Time-resolved proximity proteomics uncovers a membrane tension-sensitive caveolin-1 interactome at the rear of migrating cells

eLife
Caveolae are small membrane pits with fundamental roles in mechanotransduction. Several studies have shown that caveolae flatten out in response to increased membrane tension, thereby acting as a mechanosensitive membrane reservoir that buffers acute ...
Eleanor Martin, Rossana Girardello, Gunnar Dittmar, Alexander Ludwig   +3 more
doaj   +1 more source