Results 61 to 70 of about 29,154 (226)

Caveolae-associated signalling in smooth muscle

, 2004
Caveolae are flask-shaped invaginations in the membrane that depend on the contents of cholesterol and on the structural protein caveolin. The organisation of caveolae in parallel strands between dense bands in smooth muscle is arguably unique.
Bergdahl, Andreas,, Lund University., Swärd, Karl,   +2 more
core   +2 more sources

Beyond Biomimetics: Pathology‐Informed Engineering Rescues Reconstituted HDL From Inflammatory Dysfunction for Sepsis Immunotherapy

Advanced Science, EarlyView.
A pathology‐informed engineering strategy rescues reconstituted HDL from inflammatory dysfunction in sepsis. By integrating a ceria nanozyme‐celastrol coordination complex, the platform preserves HDL structure and endotoxin handling, sustains hierarchical intracellular delivery, and enhances immunoregulation across pathological models, translating ...
Han Zhou, Lei Zhang, Xingyu Cai, Jiajia Su, Guangyu Dai, Xue Chen, Hanming Wang, Jia Hua, Jianping Liu, Chunmeng Sun, Xiancheng Chen, Erhao Wang, Wenli Zhang   +12 more
wiley   +1 more source

Cell Surface Orifices of Caveolae and Localization of Caveolin to the Necks of Caveolae in Adipocytes

, 2003
Caveolae are noncoated invaginations of the plasma membrane that form in the presence of the protein caveolin. Caveolae are found in most cells, but are especially abundant in adipocytes.
Strålfors, Peter,, Örtegren Kugelberg, Unn,, Fredrik H. Nystrom, Margareta Karlsson, Gustavsson, Johanna,, Karin G. Stenkula, Johanna Gustavsson, Thorn, Hans,, Stenkula, Karin G.,, Karlsson, Margareta,, Nyström, Fredrik H.,, Hans Thorn, Unn Örtegren, Peter Strålfors   +13 more
core   +1 more source

Analysis of Protein and Lipid Interactions Using Liposome Co-sedimentation Assays

, 2020
The dynamic assembly of proteins at the membrane interphase is key to many cell biological processes such as the generation and stabilization of caveolae at the cell surface via coat proteins.
Hubert, Madlen, Hubert, Madlen,, Madlen Hubert, Lundmark, Richard, Lundmark, Richard,, Larsson, Elin,, Elin Larsson, Richard Lundmark, Larsson, Elin   +8 more
core   +1 more source

A computational investigation of cardiac caveolae as a source of persistent sodium current

Frontiers in Physiology, 2011
Recent studies of cholesterol-rich membrane microdomains, called caveolae, reveal that caveolae are reservoirs of recruitable sodium ion channels. Caveolar channels constitute a substantial and previously unrecognized source of sodium current in cardiac ...
Ian M. Besse, Ian M. Besse, Colleen C. Mitchell, Thomas J. Hund, Erwin F. Shibata   +4 more
doaj   +1 more source

Assembled Hyaluronic Acid Therapeutics for Targeting M1 Macrophages and Regulating Immune Homeostasis for Ulcerative Colitis Treatment

Advanced Science, EarlyView.
An orally administered, drug‐free hyaluronic acid nanoassembly, uhNAs‐OA, accumulates in the inflamed colon and is preferentially internalized by M1‐like macrophages via HA‐CD44 interactions. uhNAs‐OA scavenges excess ROS, suppresses NF‐κB signaling and remodels the colonic immune landscape, resulting in robust therapeutic efficacy in acute, chronic ...
Jianqin Wan, Andi Ma, Yiqiong Zhang, Minghao Zhang, Yifeng Lin, Xiaoling Zhang, Hongjun Li, Weidong Han   +7 more
wiley   +1 more source

Caveolae and signalling in cancer.

, 2015
It has been over 20 years since the discovery that caveolar lipid rafts function as signalling organelles. Lipid rafts create plasma membrane heterogeneity, and caveolae are the most extensively studied subset of lipid rafts. A newly emerging paradigm is
Federica Sotgia, Michael P. Lisanti, Sotgia, Federica, Lisanti, Michael P, Ubaldo E. Martinez-Outschoorn, Martinez-Outschoorn, Ubaldo E, Martinez-Outschoorn, UE, Lisanti, MP   +7 more
core   +1 more source

Evidence for vesicles that mediate long-chain fatty acid uptake by human microvascular endothelial cells

Journal of Lipid Research, 2002
This study analyzes the mechanisms of long-chain fatty acid (LC311) uptake by human microvascular endothelial cells (HMEC). The time course revealed the presence of an early, carrier-mediated uptake component and a later component mediated by clathrin ...
Axel Ring, Jürgen Pohl, Alfred Völkl, Wolfgang Stremmel   +3 more
doaj   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

A combination of systemic mannitol and mannitol modified polyester nanoparticles for caveolae-mediated gene delivery to the brain

Molecular Therapy: Nucleic Acids
Overcoming the blood-brain barrier (BBB) remains a significant challenge for nucleic acid delivery to the brain. We have explored a combination of mannitol-modified poly (β-amino ester) (PBAE) nanoparticles and systemic mannitol injection for crossing ...
Betsy Reshma Gilbert, Chirag Miglani, Arundhati Karmakar, Muneesh Pal, Vysakh C. Chandran, Sarika Gupta, Asish Pal, Munia Ganguli   +7 more
doaj   +1 more source