Results 51 to 60 of about 44,676 (226)

Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsaturated Lipids for Combined Antioxidant, Anti‐Apoptotic, and Neurotrophic Treatments

Advanced Healthcare Materials, EarlyView.
Ionizable lipid nanoparticles target multiple pathological pathways in neurodegeneration. The designed self‐assembled materials undergo a pH‐triggered structural transformation from a cubosome/hexosome coexistence to a hexosome phase, enhancing intracellular delivery of a multi‐target phytochemical formulation. The antioxidant‐loaded pH‐responsive LNPs
Thelma Akanchise, Fucen Luo, Borislav Angelov, Yuru Deng, Angelina Angelova   +4 more
wiley   +1 more source

Caveolae in Rabbit Ventricular Myocytes: Distribution and Dynamic Diminution after Cell Isolation [PDF]

, 2017
Caveolae are signal transduction centers, yet their subcellular distribution and preservation in cardiac myocytes after cell isolation are not well documented.
Alexander D. Corbett, Andreas Hoenger, Aravamudan, Baczkó, Balijepalli, Balijepalli, Bozzola, Brette, Bub, Bősze, Calaghan, Calaghan, Carozzi, Cheng, Di Maio, Drab, Dulhunty, Eva A. Rog-Zielinska, Forbes, Galbiati, Galiñanes, Gil Bub, Golowasch, Groulx, Hagiwara, Hansen, Harken, Harvey, Hayashi, Head, Hong, Ilona Bodi, Iribe, Ishikawa, Jayasinghe, Judith Sheldon, Jung, Karnovsky, Kawamura, Kohl, Kong, Kozera, Kremer, Levin, Liu, Louch, Löhn, Macdougall, Maguy, Martin Fink, Mastronarde, Mitcheson, Mitcheson, Mundy, Murata, Nerbonne, Ostrom, Palade, Panfilov, Parton, Parton, Pavlović, Pelkmans, Pelkmans, Pelkmans, Peter Kohl, Peyronnet, Pfeiffer, Quinn, Razani, Rebecca A.B. Burton, Rog-Zielinska, Rothberg, Rybin, Rémi Peyronnet, Sarah C. Calaghan, Savio-Galimberti, Scardigli, Scherer, Scriven, Sens, Serna, Simons, Sinha, Song, Stahlhut, Stan, Steinberg, Sun, Tang, Trump, Valentin, Wagner, Way, Wong, Woodman, Wright, Yaniv   +97 more
core   +2 more sources

CORE: Cholesterol Altered Lipid Nanoparticles for Splenic Expression of mRNA Payloads

Advanced Healthcare Materials, EarlyView.
In this paper researchers introduce CORE LNPs, a new class of lipid nanoparticles engineered to redirect mRNA expression away from the liver and into the spleen, a key immune organ. By combining chemical design with computational tools, they created cholesterol analogs that enable precise spleen‐targeted expression, providing greater applications for ...
Eshan A. Narasipura, Vincent Fung, Rachel VanKeulen‐Miller, Palas B. Tiwade, Owen S. Fenton   +4 more
wiley   +1 more source

Dystrophy-associated caveolin-3 mutations reveal that caveolae couple IL6/STAT3 signaling with mechanosensing in human muscle cells

Nature Communications, 2019
Caveolae are mechanosensors and mutations of their coat proteins are implicated in muscle disorders, but molecular mechanisms are unclear. Here, the authors show that caveolae can regulate IL6/STAT3 signaling in muscle cells under stress, and that ...
Melissa Dewulf, Darius Vasco Köster, Bidisha Sinha, Christine Viaris de Lesegno, Valérie Chambon, Anne Bigot, Mona Bensalah, Elisa Negroni, Nicolas Tardif, Joanna Podkalicka, Ludger Johannes, Pierre Nassoy, Gillian Butler-Browne, Christophe Lamaze, Cedric M. Blouin   +14 more
doaj   +1 more source

Assessing the Barriers to Universal Antiretroviral Treatment Access for HIV/AIDS in South Africa [PDF]

, 2004
Caveolae are a type of invaginated membrane domain that has been shown to be involved in several disease states, including lipodystrophy, muscular dystrophies and cancer.
Walker, Mary Beth
core   +1 more source

Shellac‐Mediated Assembly of Nanoparticles for mRNA Delivery

Advanced Healthcare Materials, EarlyView.
A shellac‐mediated nanoparticle assembly strategy is presented, involving the complexation of mRNA and low‐molecular‐weight cationic molecules (e.g., polyethyleneimine, chitosan, lipids, and poly‐l‐lysine), followed by capping with shellac. This nanoparticle platform enables mRNA transfection following intravenous injection and facilitates gene editing
Meizhang Lu, Jingqu Chen, Zhixing Lin, Wanjun Xu, Tianzheng Wang, Shiyao Li, Die Yang, Frank Caruso   +7 more
wiley   +1 more source

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Caveolae-Independent Activation of Protein Kinase A in Rat Neonatal Myocytes

Journal of Pharmacological Sciences, 2005
Cardiomyocytes express both β1- and β2-adrenergic receptors, and these receptors play a differential role in chronotropic and inotropic effects of the heart. Caveolae are known as an important regulator of G-protein-coupled receptor signaling.
Masashi Fukutomi, Motohiro Nishida, Yoshiko Maruyama, Hiroyuki Kobayashi, Hitoshi Kurose   +4 more
doaj   +1 more source

Intracellular trafficking and cellular uptake mechanism of PHBV nanoparticles for targeted delivery in epithelial cell lines [PDF]

, 2017
Indexación: Web of Science; Scopus; Scielo.Background: Nanotechnology is a science that involves imaging, measurement, modeling and a manipulation of matter at the nanometric scale.
Cabana-Brunod, M, Fuentes, JA, Gonzalez-Nilo, FD, Llancalahuen, FM, Maldonado-Biermann, F, Marquez-Miranda, V, Otero, C, Penaloza, JP, Reyes-Ramirez, R, Rodriguez-Diaz, M, Velasquez, LA, Vilos, C   +11 more
core   +1 more source

Turning Unpredictable Biomolecule Adsorption to Controlled Corona Formation: Focus on Carbon Nanomaterials

Advanced Materials, EarlyView.
Controlling the protein corona formation onto carbon nanomaterials (CNMs) enhances their functionalities as platforms for cancer theranostics. Here, we reviewed the effects of the intrinsic and acquired properties of CNMs on protein corona formation, the consequent biological and toxicological outcomes, and the strategies to reshape corona formation ...
Yajuan Zou, Yalei Hu, Jie Yu, Naoki Komatsu, Yuta Nishina, Alberto Bianco   +5 more
wiley   +1 more source