Results 11 to 20 of about 55,130 (252)
Caveolin-1, caveolae, and glioblastoma [PDF]
Neuro-Oncology, 2012 Glioblastoma multiforme (GBM) is the most common malignant brain tumor and is characterized by high invasiveness, poor prognosis, and limited therapeutic options. Biochemical and morphological experiments have shown the presence of caveolae in glioblastoma cells. Caveolae are flask-shaped plasma membrane subdomains that play trafficking, mechanosensing,
Parat, Marie-Odile, Riggins, Gregory J.
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Lipid organization by the Caveolin-1 complex. [PDF]
Biophys JAbstractCaveolins are lipid-binding proteins that can organize membrane remodeling and oligomerize into the 8S-complex. The CAV1 8S-complex comprises a disk-like structure, about 15nm in diameter, with a central beta barrel. Further oligomerization of 8S-complexes remodels the membrane into caveolae vessels, with a dependence on cholesterol ...
Liebl K, Voth GA.
europepmc +4 more sources
Glycosphingolipid Mediated Caveolin-1 Oligomerization [PDF]
Journal of Glycomics & Lipidomics, 2012 We have previously demonstrated an association between the accumulation of the glycosphingolipid globotriaosylceramide (Gb3) and the loss of high molecular weight oligomers in the aortas of α-galactosidase A-knockout mice, a model of Fabry disease. In the present study the molecular basis for the association between glycosphingolipids and caveolin-1 ...
Liming, Shu, James A, Shayman
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Caveolin‐1, cancer and therapy resistance [PDF]
International Journal of Cancer, 2018 Resistance of solid tumors to chemo‐ and radiotherapy remains a major obstacle in anti‐cancer treatment. Herein, the membrane protein caveolin‐1 (CAV1) came into focus as it is highly expressed in many tumors and high CAV1 levels were correlated with tumor progression, invasion and metastasis, and thus a worse clinical outcome.
Julia Ketteler, Diana Klein
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Caveolin-1 Signaling in Lung Fibrosis [PDF]
The Open Rheumatology Journal, 2012 Caveolin-1 is a master regulator of several signaling cascades because it is able to bind to and thereby inhibit members of a variety of kinase families. While associated with caveolae and involved in their generation, caveolin-1 is also present at other sites.
Tourkina, Elena, Hoffman, Stanley
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Decreased expression of caveolin 1 in patients with systemic sclerosis: crucial role in the pathogenesis of tissue fibrosis. [PDF]
, 2008 OBJECTIVE: Recent studies have implicated caveolin 1 in the regulation of transforming growth factor beta (TGFbeta) downstream signaling. Given the crucial role of TGFbeta in the pathogenesis of systemic sclerosis (SSc), we sought to determine whether ...
de Almeida, Cecilia J. +6 more
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Caveolin-1 expression is elevated in claudin-low mammary tumor cells
Cancer Cell International, 2012 Background Caveolin-1 is a scaffolding protein found in plasma membrane invaginations known as caveolae. Caveolin-1 can regulate a number of intracellular processes such as signal transduction, cholesterol metabolism and vesicular transport. With respect
Thompson Devan E +2 more
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Journal of the Egyptian National Cancer Institute, 2017 Caveolin-1 may play a role in cancer development and progression. The aim was to record the expression and localization of caveolin-1 in benign prostatic hyperplasia (BPH), high grade prostatic intraepithelial neoplasia (HGPIN) and prostatic carcinoma ...
Dareen A. Mohammed, Duaa S. Helal
doaj +1 more source
Journal of Lipid Research, 2002 The Niemann-Pick C1 (NPC1) protein regulates cholesterol transport from late endosomes-lysosomes to other intracellular compartments. In this article, cholesterol transport to caveolin-1 and caveolin-2 containing compartments, such as the trans-Golgi ...
William S. Garver +5 more
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Sterol Carrier Protein-2 Directly Interacts with Caveolin-1 in Vitro and in Vivo [PDF]
, 2004 HDL-mediated reverse-cholesterol transport as well as phosphoinositide signaling are mediated through plasma membrane microdomains termed caveolae/lipid rafts.
Atshaves, Barbara P. +7 more
core +2 more sources