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Two distinct caveolin-1 domains mediate the functional interaction of caveolin-1 with protein kinase A

American Journal of Physiology-Cell Physiology, 2001
Numerous components of the cAMP-based signaling cascade, namely G-proteins and G- protein coupled receptors, adenylyl cyclase, and protein kinase A (PKA) have been localized to caveolae and shown to be regulated by the caveolar marker proteins, the caveolins.
Babak Razani, Michael P. Lisanti
openaire   +2 more sources

The role of caveolin-1 in the regulation of angiogenesis

Italian journal of anatomy and embryology, 2012
Caveolin-1 (cav-1) is the principal structural component of caveolae which functions as scaffolding protein for the integration of a variety of signaling pathways. In this study, we show that siRNA-induced cav-1 down regulation in human endothelial cells (EC) increased cell size and provoked cell cycle arrest at G1/S phase transition.
D'Alessio, Alessio, Sica, Gigliola
openaire   +4 more sources

Expression of CAVEOLIN 1 in uterine mesenchymal tumors: No relationship between malignancy and CAVEOLIN 1 expression

Biochemical and Biophysical Research Communications, 2015
Although most smooth muscle neoplasms detected in the human uterus are benign, uterine leiomyosarcoma (Ut-LMS) is extremely malignant with high rates of recurrence and metastasis. CAVEOLIN 1 (CAV1) levels in the epithelial cells of some carcinomas have been reported to increase during tumor progression. We herein evaluated the relationship between CAV1
Tomoyuki Ichimura   +4 more
openaire   +2 more sources

Caveolin-1 and Prostate Cancer Progression

2012
Caveolin-1 was identified in the 1990s as a marker of aggressive prostate cancer. The caveolin-1 protein localizes to vesicular structures called caveolae and has been shown to bind and regulate many signaling proteins involved in oncogenesis. Caveolin-1 also has lipid binding properties and mediates aspects of cholesterol and fatty acid metabolism and
Michael R. Freeman   +5 more
openaire   +3 more sources

Caveolin 1 is a marker of poor differentiation in Rhabdomyosarcoma

European Journal of Cancer, 2011
Caveolins consist of three different membrane scaffolding proteins that play a variety of processes in different tissues. In skeletal muscle caveolins are differentially distributed, with Caveolin 1 (Cav-1) being uniquely expressed in satellite cells and Caveolin 3 (Cav-3) in mature myofibers. Rhabdomyosarcoma (RMS) represents the most common childhood
ROSSI, Stefania   +6 more
openaire   +4 more sources

CAVEOLIN-1: Role in Cell Signaling

2012
Caveolins (Cavs) are integrated plasma membrane proteins that are complex signaling regulators with numerous partners and whose activity is highly dependent on cellular context. Cavs are both positive and negative regulators of cell signaling in and/or out of caveolae, invaginated lipid raft domains whose formation is caveolin expression dependent ...
Cecile Boscher, Ivan R. Nabi
openaire   +2 more sources

Serum caveolin-1 levels in patients with preeclampsia

The Journal of Maternal-Fetal & Neonatal Medicine, 2018
Aim: The expressions of caveolin-1 have only been examined in the placental tissue of patients with preeclampsia and were reported to be low. Therefore, we decided to investigate the maternal serum levels of caveolin-1 in patients with preeclampsia.Material and methods: This cross-sectional study was conducted including 87 pregnant women; 32 with ...
Tayfur Cift   +8 more
openaire   +4 more sources

Caveolin-1

2017
Samapika Routray   +2 more
openaire   +1 more source

Role of caveolin-1 in osteoclastogenesis

Bone Abstracts, 2014
Hong-Hee Kim   +2 more
openaire   +2 more sources

Immunoexpression of caveolin-1 in human meningiomas.

2006
BARRESI, Valeria   +6 more
openaire   +2 more sources

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