Results 91 to 100 of about 6,074 (242)

Caveolin-1 and Caveolin-2 Can Be Antagonistic Partners in Inflammation and Beyond

Frontiers in Immunology, 2017
Caveolins, encoded by the CAV gene family, are the main protein components of caveolae. In most tissues, caveolin-1 (Cav-1) and caveolin-2 (Cav-2) are co-expressed, and Cav-2 targeting to caveolae depends on the formation of heterooligomers with Cav-1 ...
Cecília Jacques Gonçalves de Almeida
doaj   +1 more source

Current concepts on the role of inflammation in COPD and lung cancer [PDF]

, 2009
Chronic obstructive pulmonary disease (COPD) and lung cancer are leading cause of death, and both are associated with cigarette smoke exposure. It has been shown that 50–70% of patients diagnosed with lung cancer suffer from COPD, and reduced lung ...
Abdel-Aziz, Adenuga, Barnes, Bonomi, Brock, Campisi, Cao, Chen, Edirisinghe, Fong, Gebel, Goswami, Gozuacik, Gridelli, Hogg, Hogg, Hongwei Yao, Houghton, Irfan Rahman, Ito, Kamlah, Kasahara, Lee, Liu, Liu, Mannino, Marwick, Michaud, Moghaddam, Morris, Nozik-Grayck, Parimon, Pilette, Rajendrasozhan, Reiman, Rossi, Saitoh, Scherz-Shouval, Senderowicz, Siafakas, Sun, Takizawa, Tomita, Tsuji, van der Strate, van Houwelingen, Voelkel, Yamamoto, Yang, Yang, Yao, Yue   +51 more
core   +1 more source

Adversarial Erasing Enhanced Multiple Instance Learning (siMILe): Discriminative Identification of Oligomeric Protein Structures in Single Molecule Localization Microscopy

Advanced Intelligent Systems, EarlyView.
Hallgrimson et al. introduce a machine learning algorithm, siMILe, that takes features of single‐molecule localization microscopy localization clusters (e.g., size and sphericity) and finds the clusters that are associated with certain cell conditions (such as differential protein expression or drug treatment).
Christian Hallgrimson, Y. Lydia Li, Claire A. Shou, Ben Cardoen, John Lim, Timothy H. Wong, Ismail M. Khater, Ivan Robert Nabi, Ghassan Hamarneh   +8 more
wiley   +1 more source

Metformin enhances external urethral sphincter integrity and restores continence via AMPK activation in a rat model of stress urinary incontinence

Animal Models and Experimental Medicine, EarlyView.
The pathogenesis of stress urinary incontinence (SUI) is intimately associated with injury to the external urethral sphincter (EUS). In this study, we established an SUI model induced by double vaginal distension and demonstrated that metformin treatment activated the AMPK signaling in the EUS tissue.
Yuting Xu, Xuhong Li, Alvaro Munoz, Li Jiang, Lihua Huang, Yanhua Zhou, Liping Zhu, Youbo Yang   +7 more
wiley   +1 more source

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

Caveolin-3 in muscular dystrophy [PDF]

Human Molecular Genetics, 1998
The dystrophin-glycoprotein complex (DGC) serves as a link between cytoplasmic actin, the membrane and the extracellular matrix of striated muscle. Genetic defects in genes encoding a subset of DGC proteins result in muscular dystrophy and a secondary decrease in other DGC proteins.
E M, McNally, E, de Sá Moreira, D J, Duggan, C G, Bönnemann, M P, Lisanti, H G, Lidov, M, Vainzof, M R, Passos-Bueno, E P, Hoffman, M, Zatz, L M, Kunkel   +10 more
openaire   +2 more sources

CAV1 inhibits metastatic potential in melanomas through suppression of the Integrin/Src/FAK signaling pathway. [PDF]

, 2010
Caveolin-1 (CAV1) is the main structural component of Caveolae which are plasma membrane invaginations that participate in vesicular trafficking and signal transduction events.
Aplin, Andrew E, Bonuccelli, Gloria, Capozza, Franco, Daumer, Kristin M, Lisanti, Michael P, Milliman, Janet N, Pestell, Richard G, Sotgia, Federica, Trimmer, Casey, Whitaker-Menezes, Diana   +9 more
core   +2 more sources

Hepatotoxicity of Nonesterified Fatty Acids to Dairy Cows: Pathophysiological Mechanisms and Prospective Solutions

Animal Research and One Health, EarlyView.
Unregulated inflammation increases non‐esterified fatty acids (NEFAs), and triggers multi‐pathway hepatocyte damage including oxidative stress, mitochondrial dysfunction, and metabolic disorders in dairy cows. ABSTRACT Circulating concentrations of nonesterified fatty acids (NEFAs) are elevated due to lipid mobilization from adipose tissue in ...
Siqing Mao, Yuan Tian, Dan Li, Lei Tian, Hang Yu, Ziling Liu, Xin Gao, Yanqiong Wen, Fachun Wan, Zuo Wang, Weijun Shen, Xinwei Li, Lei Liu   +12 more
wiley   +1 more source

Regulation of raft architecture [PDF]

, 2018
Summary: Raft membrane domains are envisioned as lateral assemblies of cholesterol and sphingolipids which adopt a liquid-ordered membrane phase. Our understanding of the raft architecture in cell membranes is developing rapidly.
Harder, T., Scheiffele, P.
core  

Targeting neurogenesis: a promising therapeutic strategy for post-stroke treatment with Chinese herbal medicine [PDF]

, 2014
published_or_final_versio
Chen, X, Chen, X, Deng, R, Shen, J
core   +1 more source