Results 151 to 160 of about 3,741 (219)

Simulations suggest a scaffolding mechanism of membrane deformation by the caveolin 8S complex. [PDF]

Biophys J, 2023
Vasquez Rodriguez SY, Lazaridis T.
europepmc   +1 more source

Calpeptin Reduces Extracellular Vesicle Secretion and Induces Anti‐Inflammatory Effects but Upregulates HO‐1 and Alters Adiponectin Levels in Human Adipocytes

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT Recent studies have shown that adipose tissue (AT) secretes elevated levels of extracellular vesicles (EVs) in obesity, and these EVs play roles in metabolic diseases. The inhibition of calpains has anti‐inflammatory and anti‐fibrotic effects on AT in mice and reduces EV secretion in some cell types in vitro.
Johanna Matilainen, Sanni Foster, Viivi Berg, Janne Tampio, Tanja Turunen, Anne‐Mari Mustonen, Heikki Kyykallio, Maija Vaittinen, Ville Männistö, Jussi Pihlajamäki, Marjo Malinen, Sanna Oikari, Pirjo Käkelä, Dorota Kaminska, Veera Luukkonen, Kristiina M. Huttunen, Martin Wabitsch, Petteri Nieminen, Kirsi Rilla   +18 more
wiley   +1 more source

Caveola and Its Resident Proteins, Caveolin-1 and -2, Play Critical Roles in the Pathogenesis of nAMD and PCV. [PDF]

Invest Ophthalmol Vis Sci
Yu RMC, Oguz G, Fu NY, Shihabuddeen WA, Cheung C, Wang X, Wong TY, Cheung CMG, Ramasamy A, Yanagi Y.   +9 more
europepmc   +1 more source

Proteomic Atlas of Notochordal Cell‐Derived Extracellular Vesicles Highlights EV‐Specific NF‐κB Modulation and Functional Implications of the Protein Corona

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT The notochord is a central signalling hub during embryonic development. After regression of the notochord, notochordal cells (NCs) reside within the developing intervertebral disc. The NC‐secretome, including matrix, proteins and extracellular vesicles (NC‐EVs), promotes regeneration of degenerate intervertebral discs and cartilage. This study
Josette C. van Maanen, Chantal Voskamp, Frank M. Riemers, Harmjan R. Vos, Anouk Eversdijk, Marije Kleinjan, Menno Bergmeijer, Martijn J. C. van Herwijnen, Stuart C. Howes, Frances C. Bach, Tim J. M. Welting, Christine L. Le Maitre, Guus G. H. van den Akker, Marca H. M. Wauben, Mariana A. Tryfonidou   +14 more
wiley   +1 more source

Caveolin in extracellular vesicles: orchestrating interorgan communication in diabetes-associated cardiovascular disease^☆. [PDF]

Curr Opin Physiol
Meng Z, Sewell-Loftin MK, Thomas V, Ma X, Wang Y.   +4 more
europepmc   +1 more source

Intelligent design of artificial biocatalyst for biomedical diseases

Journal of Intelligent Medicine, Volume 3, Issue 3, Page 220-249, September 2026.
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang, Nan Song, Huanhuan Qiao, Si Sun   +3 more
wiley   +1 more source

Heparan Sulfate Proteoglycans: Master Regulators of Cellular Signaling, Tissue Development, and Neural Function

Journal of Neuroscience Research, Volume 104, Issue 9, September 2026.
Ubiquitous cell‐associated, cytoplasmic, synaptic and extracellular matrix HS‐proteoglycans are multifunctional regulators of tissue form and function. HS‐proteoglycans have diverse functions as growth factor co‐receptors in cell proliferation, differentiation, tissue development, mechanical stabilization, synaptogenesis, synaptic plasticity, and ...
James Melrose
wiley   +1 more source

Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen, Jiayan Jiao, Huiling Yang, Tao He   +3 more
wiley   +1 more source

Caveolae: Metabolic Platforms at the Crossroads of Health and Disease. [PDF]

Int J Mol Sci
Stea DM, D'Alessio A.
europepmc   +1 more source

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

MedComm, Volume 7, Issue 9, September 2026.
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng, Yiwen Zhou, Jinglun Zhang, Huang Li   +6 more
wiley   +1 more source