Role of Caveolae and Caveolin in Vascular Physiology and Pathology. [PDF]
Zhang C, Hu W, Zhang J, Wang Z, Lu H.
europepmc +1 more source
Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy
ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling +6 more
wiley +1 more source
DHCR24 Alleviates DNA Damage in Senescent Vascular Endothelial Cells via ENKUR/Ca2+ Signaling
In senescent vascular endothelial cells, DHCR24 deficiency triggers ENKUR‐dependent Ca2+ overload, which in turn induces endoplasmic reticulum stress and mitochondrial dysfunction, ultimately exacerbating oxidative stress and DNA damage. ABSTRACT DNA damage is considered one of the major contributors to aging.
Han Li +11 more
wiley +1 more source
Caveolin assemblies displace one bilayer leaflet to organize and bend membranes. [PDF]
Doktorova M +12 more
europepmc +1 more source
Slit2/Robo Signaling Restores Diabetic Erectile Function via Neurovascular Remodeling
ABSTRACT Background Diabetes mellitus‐induced erectile dysfunction (DMED) is a common and debilitating vascular‐neurogenic complication of diabetes. The poor responsiveness of DMED patients to phosphodiesterase type‐5 inhibitors underscores the need for therapies capable of restoring both endothelial integrity and cavernous nerve function.
Sen Fu +7 more
wiley +1 more source
Caveolin-3: therapeutic target for diabetic myocardial ischemia/reperfusion injury. [PDF]
Wen X +8 more
europepmc +1 more source
TRPA1 Regulates Fibrosis‐Associated Transcriptional Pathways in Human Lung Epithelial Cells
ABSTRACT Transient receptor potential ankyrin 1 (TRPA1) is a cation channel originally identified in lung fibroblasts and extensively studied in sensory neurons, where it is associated with pain and neurogenic inflammation. We and others have recently shown that TRPA1 is also expressed in lung epithelial cells and that its expression is regulated by ...
Leevi Halonen +5 more
wiley +1 more source
AREG coordinates cell proliferation and lipid metabolism reprogramming during liver regeneration and targeting lipid metabolism can promote liver regeneration. ABSTRACT Hepatocyte proliferation restores liver mass after partial hepatectomy (PHx), but the metabolic cost of this process remains unclear.
Yuelei Hu +7 more
wiley +1 more source
Lipid rafts, caveolae, and epidermal growth factor receptor family: friends or foes? [PDF]
Ruzzi F +9 more
europepmc +1 more source
In Vitro Effects of Anaesthetic Compounds on a Panel of Solid Tumour Cell Lines—An Exploratory Study
ABSTRACT Anaesthetic agents are essential for surgical procedures, yet their potential role on tumour cell biology remains incompletely understood. Emerging evidence suggests that these compounds can act both as protumor and antitumor agents, influencing cellular processes such as proliferation, migration and cell death mechanisms.
Olga Grajdieru +14 more
wiley +1 more source

