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MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes [PDF]

open access: yesJournal of Cell Biology, 2009
Polymerase I and transcript release factor (PTRF)/Cavin is a cytoplasmic protein whose expression is obligatory for caveola formation. Using biochemistry and fluorescence resonance energy transfer–based approaches, we now show that a family of related proteins, PTRF/Cavin-1, serum deprivation response (SDR)/Cavin-2, SDR-related gene product that binds ...
Michele Bastiani   +2 more
exaly   +4 more sources
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Cavin-1 promotes M2 macrophages/microglia polarization via SOCS3

Inflammation Research, 2022
Our study aimed to investigate the function of Cavin-1 and SOCS3 in macrophages/microglia M2 polarization and further explored the relevant mechanism.Expression levels of Cavin-1 and SOCS3 in macrophages/microglia were measured by western blotting and RT-PCR, respectively. Then, Cavin-1 or SOCS3 was gene silenced by a siRNA approach, and gene silencing
Fan Xu
exaly   +3 more sources

Cavin proteins: New players in the caveolae field

Biochimie, 2011
Caveolae are specialized lipid microdomains, forming small invaginations in the plasma membrane, known to be implicated in multiple functions including lipid storage, cell signaling and endocytosis. Formation of these wide flask-shaped invaginations is dependent on the expression of a caveolar coat protein, namely caveolin.
Nolwenn Briand   +2 more
exaly   +3 more sources

Biogenesis of Caveolae: Stepwise Assembly of Large Caveolin and Cavin Complexes [PDF]

open access: yesTraffic, 2010
We analyzed the assembly of caveolae in CV1 cells by following the fate of newly synthesized caveolin-1 (CAV1), caveolin-2 and polymerase I and transcript release factor (PTRF)/cavin-1 biochemically and using live-cell imaging. Immediately after synthesis in the endoplasmic reticulum (ER), CAV1 assembled into 8S complexes that concentrated in ER exit ...
Arnold Hayer   +2 more
exaly   +4 more sources

Caveolin and cavin family members: Dual roles in cancer

Biochimie, 2014
Caveolae are specialized plasma membrane subdomains with distinct lipid and protein compositions, which play an essential role in cell physiology through regulation of trafficking and signaling functions. The structure and functions of caveolae have been shown to require the proteins caveolins.
Reshu Gupta   +2 more
exaly   +3 more sources

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