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The mechanism and biomarker function of Cavin-2 in lung ischemia-reperfusion injury

Computers in Biology and Medicine, 2022
BACKGROUND Lung Ischemia Reperfusion injury(LIRI) is one of the most predominant complications of ischemic lung disease. Cavin-2 emerged as a regulator of a variety of cellular processes, including endocytosis, lipid homeostasis, signal transduction and ...
Sun Linao
exaly   +2 more sources

Cavin proteins: New players in the caveolae field [PDF]

open access: yesBiochimie, 2011
Caveolae are specialized lipid microdomains, forming small invaginations in the plasma membrane, known to be implicated in multiple functions including lipid storage, cell signaling and endocytosis. Formation of these wide flask-shaped invaginations is dependent on the expression of a caveolar coat protein, namely caveolin.
Nolwenn Briand   +2 more
exaly   +5 more sources

Liposome Binding Assay to Characterize the Structure and Function of Cavin Proteins. [PDF]

open access: yesMethods in molecular biology, 2020
Protein-protein and protein-lipid interactions play important roles in the assembly of protein coats that regulate membrane organization, signaling, and trafficking in eukaryotic cells. Caveolae are plasma membrane invaginations that are formed by a protein coat consisting of caveolin and cavin protein complexes.
M. Stoeber
semanticscholar   +5 more sources

Regulation of cancer cell ferroptosis by PTRF/Cavin-1

Free Radical Research
Ovarian cancer, marked by high rate of recurrence, novel therapeutic strategies are needed to improve patient outcome. One of the potential strategies is inducing ferroptosis in ovarian cancer cells.
Hui Xiang   +7 more
semanticscholar   +3 more sources

Serum amyloid A and interleukin -1β facilitate LDL transcytosis across endothelial cells and atherosclerosis via NF-κB/caveolin-1/cavin-1 pathway.

Atherosclerosis, 2023
BACKGROUND AND AIMS Inflammatory molecules play important roles in atherosclerosis. We aimed to illustrate the roles of serum amyloid A (SAA), and interleukin (IL)-1β in low density lipoproteins (LDL) transcytosis and atherosclerosis.
Xiong Jia   +4 more
semanticscholar   +1 more source

Diterpenoid tanshinone attenuates the metastasis of non-small-cell lung cancer (NSCLC) cells by inhibiting the Cavin-1-mediated ERK/Smad2 signaling pathway.

Anti-Cancer Agents in Medicinal Chemistry, 2023
OBJECTIVE The objective of this study is to explore the potential therapeutic role of diterpenoid tanshinone (DT) against non-small cell lung cancer (NSCLC) in vitro and elucidate the molecular mechanism involved in tumor metastasis.
Xiaojuan Li, Lu Wang, Gangdan Jiang
semanticscholar   +1 more source

Mechanism of CAV and CAVIN Family Genes in Acute Lung Injury based on DeepGENE.

Current Gene Therapy, 2022
BACKGROUND The fatality rate of acute lung injury (ALI) is as high as 40% to 60%. Although various factors, such as sepsis, trauma, pneumonia, burns, blood transfusion, cardiopulmonary bypass, and pancreatitis, can induce ALI, patients with these risk ...
Changsheng Li   +6 more
semanticscholar   +1 more source

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