Results 171 to 180 of about 5,482 (203)

Cavin 1 function does not follow caveolar morphology

American Journal of Physiology-Cell Physiology, 2015
The function of caveolae, small invaginations of the plasma membrane, remains a matter of debate. We discuss endocytosis and compartmentalization of metabolic and signaling pathways. Caveolin 3 (CAV3) and polymerase I and transcript release factor (PTRF) are important proteins that ensure shaping of caveolae in muscle cells.
Timmel, T., Kunz, S., Seifert, F., Schuelke, M., Spuler, S.   +4 more
openaire   +2 more sources

Down‐regulation of the cavin family proteins in breast cancer

Journal of Cellular Biochemistry, 2011
AbstractCaveolae are abundant membrane domain on the cell surface of many mammalian cell types and are implicated in a wide range of physiological processes. The caveolae structural protein caveolin‐1 is often mutated or deregulated in cancer, and cavin family protein serum deprivation response factor‐related gene product that binds to C‐kinase (SRBC ...
Lin, Bai, Xiaoli, Deng, Qian, Li, Miao, Wang, Wei, An, A, Deli, Zhuo, Gao, Yuntao, Xie, Yifan, Dai, Yu-Sheng, Cong   +9 more
openaire   +2 more sources

Cavin fever: regulating caveolae

Nature Cell Biology, 2009
SDPR is a new regulator of caveolae biogenesis. SDPR overexpression results in increased caveolae size and leads to the formation of caveolae-derived tubules containing Shiga toxin. SDPR may therefore be a membrane curvature-inducing component of caveolae.
openaire   +1 more source

Cavin-2 is a specific marker for detection of well-differentiated liposarcoma

Biochemical and Biophysical Research Communications, 2017
Caveolae are cholesterol enriched invaginations of the plasma membrane involved in a variety of processes, including glucose and fatty acids absorption, cell transduction and mechanoprotection. The biogenesis and function of caveolae depend on the activity of Caveolin (Cav-1, -2 and -3) and Cavin (Cavin-1, -2, -3 and -4) protein families.
Alessandro Fanzani, Marika Vezzoli, Manuela Cominelli   +2 more
exaly   +5 more sources

Cavin Family: New Players in the Biology of Caveolae.

International review of cell and molecular biology, 2015
Caveolae are specialized small plasma-membrane invaginations that play crucial cellular functions. Two essential protein families are required for caveola formation: membrane caveolin proteins and cytoplasmic cavin proteins. Each family includes members with specific tissue distribution, and their expression is altered under physiological and ...
Nassar, Zeyad D., Parat, Marie-Odile
openaire   +3 more sources

Increases in endothelial caveolin-1 and cavins correlate with cirrhosis progression

Micron, 2015
Caveolin-1 is associated with flat caveolar domains, invaginated smooth plasmalemmal vesicles, and caveolae. Polymerase 1 and transcript release factor (PTRF) (cavin 1) and serum deprivation protein response (SDPR) (cavin 2) are required for the invagination of caveolae, and PRKCDBP (protein kinase C, delta-binding protein; cavin 3) is required for ...
Hiroaki, Yokomori, Wataru, Ando, Kazunori, Yoshimura, Hitoshi, Yamazaki, Yoshihito, Takahashi, Masaya, Oda   +5 more
openaire   +2 more sources

Regulation of cancer cell ferroptosis by PTRF/Cavin-1

Free Radical Research
Ovarian cancer, marked by high rate of recurrence, novel therapeutic strategies are needed to improve patient outcome. One of the potential strategies is inducing ferroptosis in ovarian cancer cells. Ferroptosis is an iron-dependent, lipid peroxidation-driven mode of cell death primarily occurring on the cell membrane.
Hui, Xiang, Miao, Wang, Yi-Fang, Chen, Hao-Ming, Wu, Ming-Ge, Li, Lei, Guo, Ying-Yi, Zhang, He-Zhe, Lu   +7 more
openaire   +2 more sources

CAVEOLINS AND CAVINS IN MUSCLE-DERIVED TUMOURS

2012
Rhabdomyosarcomas (RMS) are muscle-derived tumours with a significant incidence in children. RMS cells exhibit a widespread pattern of muscle-specific markers, the detection of which may be useful for discriminating the tumour grading in order to optimize the timing and doses of chemotherapy. By analyzing human RMS specimens and in vitro cell lines, we
FAGGI, Fiorella, ZANOLA, Alessandra, Sorci G., Riuzzi F., Codenotti S., MONTI, Eugenio, FANZANI, Alessandro   +6 more
openaire   +2 more sources

Liposome Binding Assay to Characterize the Structure and Function of Cavin Proteins

2020
Protein-protein and protein-lipid interactions play important roles in the assembly of protein coats that regulate membrane organization, signaling, and trafficking in eukaryotic cells. Caveolae are plasma membrane invaginations that are formed by a protein coat consisting of caveolin and cavin protein complexes.
openaire   +3 more sources

[Cavins: new sights of caveolae-associated protein].

Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 2014
Caveolae are specialized lipid rafts that form flask-shaped invaginations of the plasma membrane. Many researches show that caveolae are involved in cell signaling and transport. Caveolin-1 is the major coat protein essential for the formation of caveolae.
Dan, Shi, Yan, Liu, Xin, Lian, Wei, Zou
openaire   +1 more source