Results 191 to 200 of about 7,336 (225)

Cavin-1 deficiency modifies myocardial and coronary function, stretch responses and ischaemic tolerance: roles of NOS over-activity [PDF]

Basic Research in Cardiology, 2017
Caveolae and associated cavin and caveolins may govern myocardial function, together with responses to mechanical and ischaemic stresses. Abnormalities in these proteins are also implicated in different cardiovascular disorders.
M. Kaakinen, M. Reichelt, Zhibin Ma, C. Ferguson, N. Martel, E. Porrello, James E. Hudson, Walter G. Thomas, R. Parton, J. Headrick   +9 more
semanticscholar   +2 more sources

Biogenesis of Caveolae: Stepwise Assembly of Large Caveolin and Cavin Complexes [PDF]

Traffic, 2010
We analyzed the assembly of caveolae in CV1 cells by following the fate of newly synthesized caveolin-1 (CAV1), caveolin-2 and polymerase I and transcript release factor (PTRF)/cavin-1 biochemically and using live-cell imaging. Immediately after synthesis in the endoplasmic reticulum (ER), CAV1 assembled into 8S complexes that concentrated in ER exit ...
Arnold Hayer, Miriam Stoeber, Ari Helenius   +2 more
exaly   +5 more sources

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Cavin-3 promotes TNF expression via the MAPK signaling pathway in lung squamous cell carcinoma.

Biochimica et Biophysica Acta - General Subjects
Cavin family proteins alter the invasiveness of tumor cells. However, research on the pathogenesis of Cavins in tumors is lacking. To address this knowledge-gap, we conducted a systematic analysis about the mechanism of action of Cavins in cancer.
Xiao-yan Xu, Yonghong Nie, Jiatuo Xu, Rilei Jiang   +3 more
semanticscholar   +1 more source

Exploring the caves: cavins, caveolins and caveolae

Trends in Cell Biology, 2010
Caveolae are ampullate (flask-shaped) invaginations that are abundant in the plasma membrane of many mammalian cell types. Although caveolae are implicated in a wide range of processes including endothelial transcytosis, lipid homeostasis and cellular signalling, a detailed molecular picture of many aspects of their function has been elusive.
Carsten G, Hansen, Ben J, Nichols
openaire   +2 more sources

Caveolin and cavin family members: Dual roles in cancer

Biochimie, 2014
Caveolae are specialized plasma membrane subdomains with distinct lipid and protein compositions, which play an essential role in cell physiology through regulation of trafficking and signaling functions. The structure and functions of caveolae have been shown to require the proteins caveolins.
Reshu Gupta, Borhane Annabi, Chirine Toufaily   +2 more
exaly   +3 more sources

Loss of Cavin-2 destabilizes PTEN and enhances Akt signaling pathway in cardiomyocytes.

Cardiovascular Research
AIMS Specific cavins and caveolins, known as caveolae-related proteins, have been implicated in cardiac hypertrophy and myocardial injury. Cavin-2 forms complexes with other caveolae-related proteins, but the role of Cavin-2 in cardiomyocytes (CMs) is ...
Naoki Maruyama, T. Ogata, Takeru Kasahara, Tetsuro Hamaoka, Yusuke Higuchi, Y. Tsuji, S. Tomita, A. Sakamoto, N. Nakanishi, S. Matoba   +9 more
semanticscholar   +1 more source

Focus on the role of Caveolin and Cavin protein families in liposarcoma

Differentiation, 2017
The identification of ancillary biomarkers useful to improve diagnosis is a major challenge for adipocytic liposarcoma (LPS), the most common type among soft tissue sarcomas affecting adulthood. Recent findings have reported the expression of some proteins belonging to Caveolin and Cavin families as a critical hallmark distinctive of the least ...
Codenotti, Silvia, Vezzoli, Marika, Monti, Eugenio, Fanzani, Alessandro   +3 more
openaire   +3 more sources

Characterisation of the cavin proteins role in the circadian rhythm [PDF]

, 2022
Caveolae are nanoscale size invaginations of the plasma membrane identified by their unique flask-shape morphology. They are considered to play an important role in lipid metabolism and provide essential mechanosensing and protective capacity to the membrane. The cytosolic coat composed of the cavin family of proteins, namely Cavin1, Cavin2, Cavin3 and
openaire   +1 more source

Cavin 1 function does not follow caveolar morphology

American Journal of Physiology-Cell Physiology, 2015
The function of caveolae, small invaginations of the plasma membrane, remains a matter of debate. We discuss endocytosis and compartmentalization of metabolic and signaling pathways. Caveolin 3 (CAV3) and polymerase I and transcript release factor (PTRF) are important proteins that ensure shaping of caveolae in muscle cells.
Timmel, T., Kunz, S., Seifert, F., Schuelke, M., Spuler, S.   +4 more
openaire   +2 more sources

Cavin-1: caveolae-dependent signalling and cardiovascular disease

Biochemical Society Transactions, 2014
Caveolae are curved lipid raft regions rich in cholesterol and sphingolipids found abundantly in vascular endothelial cells, adipocytes, smooth muscle cells and fibroblasts. They are multifunctional organelles with roles in clathrin-independent endocytosis, cholesterol transport, mechanosensing and signal transduction.
Williams, Jamie J.L., Palmer, Timothy M.
openaire   +3 more sources