Results 71 to 80 of about 11,666 (204)

Unraveling A4GALT Mechanism and Its Modulation With Adamantyl‐Galactosylceramide Analogues: Advancing Fabry Disease Therapeutic Strategies

open access: yesAngewandte Chemie, Volume 138, Issue 41, 5 October 2026.
A 310‐helix‐mediated conformational switch promotes a front‐face SNi‐like catalysis by human A4GALT. Mechanism‐guided design identifies AdaGalCer as a selective modulator of globotriaosylceramide (Gb3) biosynthesis, opening a clear route toward new Fabry disease therapeutics.
Nicky de Koster   +13 more
wiley   +2 more sources

Effect of Social Rank on Gut Microbes and Their Metabolites of Greater Long‐Tailed Hamsters (Tscherskia triton)

open access: yesIntegrative Zoology, EarlyView.
Social rank in greater long‐tailed hamsters (Tscherskia triton) shapes gut microbiota composition and metabolite profiles. Dominant males exhibit a “high‐vigilance, metabolically activated” phenotype, with elevated aggression and specific gut microbiota enriched in energy‐harvesting taxa and fecal queuine.
Da Zhang, Xiaoming Xu, Zhibin Zhang
wiley   +1 more source

Snake Gut Microbiota as a Source of Anti‐Inflammatory Probiotics: Isolation and Functional Characterization of Two Novel Strains

open access: yesIntegrative Zoology, EarlyView.
This study assessed the probiotic potential of intestinal microbiomes from five snake species using metagenomics and in vitro isolation, identifying two promising strains (Lactobacillus johnsonii DA0116 and Limosilactobacillus reuteri DA0218) through comprehensive screening.
Xuena Kang   +11 more
wiley   +1 more source

Straw-induced CAZy genes.

open access: yes, 2012
CAZy genes strongly induced (≥20 x) and expressed (≥50 RPKM) after 24 h in Straw. An02g02540 has not been annotated in the ATCC 1015 genome but was found on chromosome 4_2 (5′-669026 - 667767-3′).
Martin J. Blythe (144604)   +11 more
core   +1 more source

Association Characteristics and Potential Mechanisms of Aging, Gut Microbiota, and Hearing Loss

open access: yesIntegrative Zoology, EarlyView.
The study found that aging leads to unchanged gut microbiota alpha diversity but an increase in Bacteroidetes and a decrease in Firmicutes at the phylum level, with specific genera, species, and functional pathways co‐associated with aging and hearing loss. Through constructing a microbe‐metabolite network, it revealed the mechanism by which protective
Cheng Cheng   +7 more
wiley   +1 more source

CAZy family assignment of H. pylori glycosyltransferase genes.

open access: yes, 2019
CAZy family assignment of H. pylori glycosyltransferase genes.
Tiankuo Yang (7901588)   +22 more
core   +1 more source

Seasonal Dynamics of Community and Function of Gut Microbiome in Taihangshan Macaque (Macaca mulatta tcheliensis): Inferred From Metagenomic Data

open access: yesIntegrative Zoology, EarlyView.
A total of 435 non‐redundant metagenome‐assembled genomes (MAGs) were obtained from fecal samples of Taihangshan macaque across all four seasons. The alpha diversity of the gut microbiome in spring and winter was significantly higher than in summer and autumn. Furthermore, marked differences were detected in functional pathways and carbohydrate enzymes
Yanyan Zhou   +6 more
wiley   +1 more source

Composition and biosynthetic machinery of the Blumeria graminis f. sp. hordei conidia cell wall

open access: yesThe Cell Surface, 2019
Infection of barley with the powdery mildew causal agent, Blumeria graminis f. sp. hordei (Bgh), can lead to devastating damage to barley crops. The recent emergence of fungicide resistance imposes a need to develop new antifungal strategies. The enzymes
Trang A.T. Pham   +6 more
doaj   +1 more source

Gut Microbiota Analysis and Comparison in Forest Musk Deer (Moschus berezovskii) of Different Ages and Musk‐Secreting Periods

open access: yesIntegrative Zoology, EarlyView.
Metagenomic sequencing was used to analyze fecal microbiota of captive male forest musk deer (FMD) from the Sichuan Institute of Musk Deer Breeding across ages and musk‐secreting periods. Gut microbiota was generally stable and dominated by Firmicutes, while age and musk secretion shaped microbial composition and function, with musk collection linked ...
Jiuyan Jiang   +17 more
wiley   +1 more source

Cryo‐EM structure of GH43 β‐Xylosidase from Enterobacter cloacae provides insights into substrate specificity and the role of an auxiliary domain in enzymatic activity

open access: yesThe FEBS Journal, EarlyView.
Xylan, the second most abundant plant cell wall polysaccharide, is degraded by β‐xylanases and β‐xylosidases. Here, we present the 2.65 Å cryo‐EM structure of Enterobacter cloacae β‐xylosidase (EcXyl43, GH43) and the 2.4 Å X‐ray structure of its inactive F507A mutant.
Lorenzo Briganti   +8 more
wiley   +1 more source

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