Results 151 to 160 of about 10,682 (172)

Two distinct classes of novel pyrazolinecarboxamides as potent cannabinoid CB1 receptor agonists

Bioorganic & Medicinal Chemistry Letters, 2010
The synthesis and SAR of 3-alkyl-4-aryl-4,5-dihydropyrazole-1-carboxamides 1-23 and 1-alkyl-5-aryl-4,5-dihydropyrazole-3-carboxamides 24-27 as two novel cannabinoid CB(1) receptor agonist classes were described. The target compounds elicited high affinities to the CB(1) as well as the CB(2) receptor and were found to act as CB(1) receptor agonists. The
Jos H M, Lange, Amos, Attali, Martina A W, van der Neut, Henri C, Wals, Arie, Mulder, Hicham, Zilaout, Ate, Duursma, Hans H M, van Aken, Bernard J, van Vliet   +8 more
openaire   +2 more sources

CB1 cannabinoid receptor agonists increase intracranial self-stimulation thresholds in the rat

Psychopharmacology, 2004
Addictive drugs have a number of commonalities in animal behavioral models. They lower intracranial self-stimulation (ICSS) thresholds, support self-administration, and produce conditioned place preference (CPP). However, cannabinoids appear atypical as drugs of abuse, since there are controversial data in the literature concerning their reinforcing ...
Styliani, Vlachou, George G, Nomikos, George, Panagis   +2 more
openaire   +2 more sources

Agonist efficacy and receptor efficiency in heterozygous CB1 knockout mice: relationship of reduced CB1 receptor density to G‐protein activation

Journal of Neurochemistry, 2001
Heterozygous CB1 receptor knockout mice were used to examine the effect of reduced CB1 receptor density on G‐protein activation in membranes prepared from four brain regions: cerebellum, hippocampus, striatum/globus pallidus (striatum/GP) and cingulate cortex.
D E, Selley, W K, Rorrer, C S, Breivogel, A M, Zimmer, A, Zimmer, B R, Martin, L J, Sim-Selley   +6 more
openaire   +2 more sources

Cannabinoid Cb1 Receptor Antagonists/Inverse Agonists and Food-Seeking Behavior

2011
For the last few years, drugs that interfere with cannabinoid CB1 receptor transmission have been assessed for their potential utility as appetite suppressants. CB1 antagonists and inverse agonists have been shown to suppress a number of food-related behaviors, including food-reinforced behaviors.
John D. Salamone, Kelly Sink, Kristen N. Segovia, Patrick A. Randall, Peter J. McLaughlin, V. Kiran Vemuri, Alexandros Makriyannis   +6 more
openaire   +1 more source

Modulation of Serotonin Firing Activity Through CB1 Agonists and FAAH Inhibitors

2013
The psychological feelings produced by cannabis have been described as fatuous euphoria, elation, and talkativeness. Alternatively, cannabis can induce low mood and depression especially after chronic use. Despite these clinical evidences, little was known about the capacity of cannabis to modulate serotonin (5-Hydroxytryptamine, 5-HT), the main ...
openaire   +1 more source

Interaction of the CB1 agonist ACEA and propofol

European Journal of Anaesthesiology, 2005
P.-A. Brand, P. Meybohm, J. Scholz, F. Renhof, P. H. Tonner   +4 more
openaire   +1 more source

Role of residual CB1 receptor agonist activity in the hemodynamic profile of CB2 agonists

Journal of Pharmacological and Toxicological Methods, 2011
Patricia N. Banfor, Philip Zocharski, Betty Yao, Michael Dart, Michael Meyer, Andrew King   +5 more
openaire   +1 more source

Can dronabinol, a CB1 agonist, suppress opioid withdrawal in humans?

Drug and Alcohol Dependence, 2015
Michelle R. Lofwall, Shanna Babalonis, Claude Elayi, Paul A. Nuzzo, Kathryn E. Gill, Sharon L. Walsh   +5 more
openaire   +1 more source

Interactions between the CB1 receptor agonist Δ9-THC and the CB1 receptor antagonist SR-141716 in rats

Pharmacology Biochemistry and Behavior, 2002
Torbjörn U.C. Järbe, Matthew E. Andrzejewski, Nicholas V. DiPatrizio   +2 more
openaire   +1 more source

Allosteric Modulation: An Alternate Approach Targeting the Cannabinoid CB1 Receptor

Medicinal Research Reviews, 2017
Thuy Nguyen, Jun-Xu Li, Jenny L Wiley
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