Results 131 to 140 of about 562,936 (248)

Adolescent Exposure to a THC‐Rich Cannabis Extract Produces Genotype‐Dependent Effects on Cognition and Glial Morphology in Serine Racemase Mutant Mice

Journal of Neurochemistry, Volume 170, Issue 9, September 2026.
Adolescent exposure to a THC‐rich cannabis extract produced genotype‐dependent, contrasting effects in mice. In wild‐type animals, it altered behavior and brain glial cell structure, whereas in mice with a genetic deficiency in serine racemase, a model of impaired NMDA receptor signaling relevant to schizophrenia, it prevented cognitive and ...
Igor F. Rangel, Melissa Chaves, Iohanna Pagnoncelli, Isabelle Medeiros, Felipe Pinheiro, Lorena Fortuna, Luiza Castello‐Branco, Ernesto Diaz Roch, Virgínia Martins Carvalho, Flavia Regina Souza Lima, Rogério Panizzutti, Luciana Romão   +11 more
wiley   +1 more source

Functional Selectivity of Cannabinoid Type 1 G Protein-Coupled Receptor Agonists in Transactivating Glycosylated Receptors on Cancer Cells to Induce Epithelial–Mesenchymal Transition Metastatic Phenotype

Cells
Understanding the role of biased G protein-coupled receptor (GPCR) agonism in receptor signaling may provide novel insights into the opposing effects mediated by cannabinoids, particularly in cancer and cancer metastasis.
David A. Bunsick, Jenna Matsukubo, Rashelle Aldbai, Leili Baghaie, Myron R. Szewczuk   +4 more
doaj   +1 more source

N‐Arachidonoyl‐phosphatidylethanolamide phospholipase D activation by muscarinic receptors

The Journal of Physiology, Volume 604, Issue 18, Page 7721-7738, 15 September 2026.
Abstract figure legend Activating muscarinic M3 receptors activates Gq‐pathway signalling, including the activation of phospholipase C (PLC) and release of calcium from internal stores as shown in the upper panel. It remains unclear whether the calcium acts on N‐arachidonoyl‐phosphatidylethanolamide phospholipase D (NAPE‐PLD) itself or upstream at N ...
Natalia Murataeva, Connor Schmitt, Elyssa Hyman, Jim Wager‐Miller, Irene Matthews, Ruyi Cai, Shangxuan Cai, Yulong Li, Ken Mackie, Alex Straiker   +9 more
wiley   +1 more source

Classical cannabinoid receptors as target in cancer-induced bone pain: a systematic review, meta-analysis and bioinformatics validation

Scientific Reports
To test the hypothesis that genetic and pharmacological modulation of the classical cannabinoid type 1 (CB1) and 2 (CB2) receptors attenuate cancer-induced bone pain, we searched Medline, Web of Science and Scopus for relevant skeletal and non-skeletal ...
Feier Zeng, Abbie Wade, Kade Harbert, Shrina Patel, Joshua S. Holley, Cornelia K. Dehghanpuor, Thomas Hopwood, Silvia Marino, Antonia Sophocleous, Aymen I. Idris   +9 more
doaj   +1 more source

Overview of the effects of CB1 receptor (ant)agonists on impulsive behavior found in this study.

, 2013
Arrows indicate the direction of the effects of CB1 receptor (ant)agonists on impulsivity relative to baseline or amphetamine-induced levels of impulsivity, whereby amphetamine alone increases and decreases impulsive action and choice as compared to ...
Anton N. M. Schoffelmeer (166516), Joost Wiskerke (166492), Dustin Schetters (221994), Tommy Pattij (166531), Nicky Stoop (166507)   +4 more
core   +1 more source

Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection

Pharmacological Research
Δ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors are implicated in several forms of synaptic plasticity – depolarization-induced suppression of ...
Michaela Dvorakova, Ken Mackie, Alex Straiker   +2 more
doaj   +1 more source

The regulation of endocannabinoids after neuronal damage and the neuroprotective impact of GPR55 in organotypic hippocampal slice cultures [PDF]

, 2013
Endocannabinoids (eCB) are signaling lipids and became known for their importance in the central nervous system as well as in immune defense. Beneficial effects of eCB are shown in processes of excitotoxic lesion, secondary damage and neuronal plasticity
Kallendrusch, Sonja
core  

A Kannabinoid Receptor 1 (CB1) szerepének vizsgálata in vitro porcképződés során

, 2017
Az ízületi porcregeneráció elősegítése a mai napig nem megoldott feladat. Az elmúlt évek során felvetődött, hogy a kannabisz tartalmú készítmények alkalmazása különböző reumatoid- vagy oszteoarthritiszes megbetegedések során nemcsak fájdalomcsillapító és
Fürstál, Barbara
core  

Peripherally Restricted CB1 Receptor Inverse Agonist JD5037 Treatment Exacerbates Liver Injury in MDR2-Deficient Mice

Cells
Previous research highlighted the involvement of the cannabinoid CB1 receptor in regulating the physiology of hepatocytes and hepatic stellate cells. The inhibition of the CB1 receptor via peripherally restricted CB1 receptor inverse agonist JD5037 has ...
Jenny Chen, Fengyuan Li, Jiyeon Lee, Md Manirujjaman, Lihua Zhang, Zhao-Hui Song, Craig McClain, Wenke Feng   +7 more
doaj   +1 more source

The intervention of cannabinoid receptor in chronic and acute kidney disease animal models: a systematic review and meta-analysis

Diabetology & Metabolic Syndrome
Aim Cannabinoid receptors are components of the endocannabinoid system that affect various physiological functions. We aim to investigate the effect of cannabinoid receptor modulation on kidney disease.
Zihao Zhao, Qianqian Yan, Junwei Xie, Zhenjie Liu, Fengxun Liu, Yong Liu, Sijie Zhou, Shaokang Pan, Dongwei Liu, Jiayu Duan, Zhangsuo Liu   +10 more
doaj   +1 more source