Results 111 to 120 of about 562,936 (248)

CONSTITUTIVE ACTIVITY AT THE CANNABINOID CB1 RECEPTOR IS REQUIRED FOR BEHAVIORAL RESPONSE TO NOXIOUS CHEMICAL STIMULATION OF TRPV1: ANTINOCICEPTIVE ACTIONS OF CB1 INVERSE AGONISTS

Journal of Neuroscience, 2008
The potential modulation of TRPV1 nociceptive activity by the CB1 receptor was investigated here using CB1 wild-type (WT) and knock-out (KO) mice as well as selective CB1 inverse agonists.
B. Fioravanti, M. De Felice, C. Stucky, K. Medler, Miaw-chyi Luo, L. Gardell, Mohab M. Ibrahim, T. Malan, H. Yamamura, M. Ossipov, T. King, J. Lai, F. Porreca, T. Vanderah   +13 more
semanticscholar   +1 more source

Quantifying Heteromer Partitioning Reveals Inflammation‐Dependent Redistribution of Microglial Adenosine A2A and Cannabinoid CB2 Receptors

Glia, Volume 74, Issue 9, September 2026.
Proinflammatory activation reorganizes microglial A2A and CB2 receptors, promoting their incorporation into stable heteromers and blocking agonist‐induced redistribution. The results reveal those heteromers as potential therapeutic targets in inflammatory contexts.
Rafael Franco, Jaume Lillo, Christian Griñán‐Ferré, Mercè Pallàs, Rafael Rivas‐Santisteban   +4 more
wiley   +1 more source

Cannabinoid 1 Receptor Signaling on Hippocampal GABAergic Neurons Influences Microglial Activity

Frontiers in Molecular Neuroscience, 2018
Microglia, the resident immune cells of the brain, play important roles in defending the brain against pathogens and supporting neuronal circuit plasticity.
Frank Ativie, Joanna A. Komorowska, Eva Beins, Önder Albayram, Till Zimmer, Andreas Zimmer, Dario Tejera, Michael Heneka, Andras Bilkei-Gorzo   +8 more
doaj   +1 more source

The Role of Hippocampal Interneuron Migration in Neurodevelopmental Disorders: A Systematic Review

Hippocampus, Volume 36, Issue 5, September 2026.
ABSTRACT Hippocampal abnormalities are frequently associated with neurodevelopmental disorders as interneurons are crucial in establishing the network connectivity of neurons. This systematic review analyzed primary literature with a focus on aberrant hippocampal interneuron migration as an etiology for neurodevelopmental disorders, summarizing the ...
M. A. C. Till, H. M. O. Reid, I. Murphy, B. R. Christie   +3 more
wiley   +1 more source

Formoterol versus short-acting beta-agonists as relief medication for adults and children with asthma [PDF]

, 2010
Background Formoterol is a long-acting beta(2)-agonist but because it has a fast onset of action it can also be used as a relief medication. Objectives To asses the efficacy and safety of formoterol as reliever therapy in comparison to short-acting ...
Christopher J Cates, Emma J Welsh, Welsh, EJ, Cates, CJ   +3 more
core   +1 more source

Revealing the therapeutic potential of synthetic cannabinoids: a systematic review of cannabinoid receptor binding dynamics and their implications for cancer therapy

Journal of Cannabis Research
Background Cancer remains a major global health issue, prompting the need for innovative treatment approaches that extend beyond conventional methods such as chemotherapy and radiation.
Sahar S. Alghamdi, Hussah N. Albahlal, Danah E. Aloumi, Sarah Bin Saqyah, Arwa Alsubait, Jehan Alamre, Mohammed Alrashed, Nada Alsuhabeny, Afrah E. Mohammed   +8 more
doaj   +1 more source

Psilocybin, From Ancestral Use to Therapeutic Potential: A Multidimensional Review of Its Pharmacological Basis and Current Perspectives

Human Psychopharmacology: Clinical and Experimental, Volume 41, Issue 5, September 2026.
ABSTRACT Objective This review critically examines psilocybin, with particular emphasis on its pharmacokinetics and pharmacodynamics, including its serotonergic, neuroplastic, and anti‐inflammatory mechanisms. It integrates historical context, preclinical and clinical evidence, and evaluates emerging therapeutic potential, safety, microdosing practices,
José Norberto Vásquez‐Bonilla
wiley   +1 more source

Expresión, función y heteromerización de receptores de cannabinoides CB(2) en el sistema nervioso central [PDF]

, 2012
[spa] Dentro del sistema endocannabinoide, los receptores de cannabinoides, hasta ahora clonados y caracterizados, son principalmente dos: el de tipo 1 (CB1R) y el de tipo 2 (CB2R).
Callén Herrero, Lucía
core   +3 more sources

Synthesis and cannabinoid activity of 1-substituted-Indole-3-oxadiazole derivatives: Novel agonists for the CB1 Receptor

, 2008
An exploratory chemical effort has been undertaken to develop a novel series of compounds as selective CB1 agonists. It is hoped that compounds of this type will have clinical utility in pain control, and cerebral ischaemia following stroke or traumatic ...
Robinson, Michael, Christopoulos, Arthur, Stoermer, Martin J., Wright, Christine E., Lay, Lucy, Moloney, Gerard P., Angus, James A., Robertson, Alan D., McRae, Ken   +8 more
core   +1 more source

The Endocannabinoid System and Oligodendrocytes in Health and Disease

Frontiers in Neuroscience, 2018
Cannabinoid-based interventions are being explored for central nervous system (CNS) pathologies such as neurodegeneration, demyelination, epilepsy, stroke, and trauma. As these disease states involve dysregulation of myelin integrity and/or remyelination,
Alexander A. Ilyasov, Alexander A. Ilyasov, Carolanne E. Milligan, Carolanne E. Milligan, Emily P. Pharr, Emily P. Pharr, Allyn C. Howlett, Allyn C. Howlett   +7 more
doaj   +1 more source