Results 91 to 100 of about 10,682 (172)

Functional Selectivity of Cannabinoid Type 1 G Protein-Coupled Receptor Agonists in Transactivating Glycosylated Receptors on Cancer Cells to Induce Epithelial–Mesenchymal Transition Metastatic Phenotype

Cells
Understanding the role of biased G protein-coupled receptor (GPCR) agonism in receptor signaling may provide novel insights into the opposing effects mediated by cannabinoids, particularly in cancer and cancer metastasis.
David A. Bunsick, Jenna Matsukubo, Rashelle Aldbai, Leili Baghaie, Myron R. Szewczuk   +4 more
doaj   +1 more source

Computational Prediction and Biochemical Analyses of New Inverse Agonists for the CB1 Receptor

Journal of Chemical Information and Modeling, 2016
Human cannabinoid type 1 (CB1) G-protein coupled receptor is a potential therapeutic target for obesity. The previously predicted and experimentally validated ensemble of ligand-free conformations of CB1 [Scott, C. E. et al. Protein Sci. 2013 , 22 , 101 - 113 ; Ahn, K. H. et al.
Scott, Caitlin E., Ahn, Kwang H., Graf, Steven T., Goddard, William A., III, Kendall, Debra A., Abrol, Ravinder   +5 more
openaire   +3 more sources

Endocannabinoids affect neurological and cognitive function in thioacetamide-induced hepatic encephalopathy in mice

Neurobiology of Disease, 2006
Endocannabinoids function as neurotransmitters and neuromodulators in the central nervous system via specific receptors and apparently have a neuroprotective role.
Yosefa Avraham, Eran Israeli, Ezra Gabbay, Avital Okun, Olga Zolotarev, Isable Silberman, Vera Ganzburg, Yossi Dagon, Iddo Magen, Lia Vorobia, Orit Pappo, Raphael Mechoulam, Yaron Ilan, Elliot M. Berry   +13 more
doaj   +1 more source

Classical cannabinoid receptors as target in cancer-induced bone pain: a systematic review, meta-analysis and bioinformatics validation

Scientific Reports
To test the hypothesis that genetic and pharmacological modulation of the classical cannabinoid type 1 (CB1) and 2 (CB2) receptors attenuate cancer-induced bone pain, we searched Medline, Web of Science and Scopus for relevant skeletal and non-skeletal ...
Feier Zeng, Abbie Wade, Kade Harbert, Shrina Patel, Joshua S. Holley, Cornelia K. Dehghanpuor, Thomas Hopwood, Silvia Marino, Antonia Sophocleous, Aymen I. Idris   +9 more
doaj   +1 more source

Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection

Pharmacological Research
Δ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors are implicated in several forms of synaptic plasticity – depolarization-induced suppression of ...
Michaela Dvorakova, Ken Mackie, Alex Straiker   +2 more
doaj   +1 more source

Peripherally Restricted CB1 Receptor Inverse Agonist JD5037 Treatment Exacerbates Liver Injury in MDR2-Deficient Mice

Cells
Previous research highlighted the involvement of the cannabinoid CB1 receptor in regulating the physiology of hepatocytes and hepatic stellate cells. The inhibition of the CB1 receptor via peripherally restricted CB1 receptor inverse agonist JD5037 has ...
Jenny Chen, Fengyuan Li, Jiyeon Lee, Md Manirujjaman, Lihua Zhang, Zhao-Hui Song, Craig McClain, Wenke Feng   +7 more
doaj   +1 more source

The intervention of cannabinoid receptor in chronic and acute kidney disease animal models: a systematic review and meta-analysis

Diabetology & Metabolic Syndrome
Aim Cannabinoid receptors are components of the endocannabinoid system that affect various physiological functions. We aim to investigate the effect of cannabinoid receptor modulation on kidney disease.
Zihao Zhao, Qianqian Yan, Junwei Xie, Zhenjie Liu, Fengxun Liu, Yong Liu, Sijie Zhou, Shaokang Pan, Dongwei Liu, Jiayu Duan, Zhangsuo Liu   +10 more
doaj   +1 more source

Comparison of Agonist Activity between CB1 and CB2 Receptors with Orthosteric Site Mutations

Receptors
Human endocannabinoid signaling is primarily mediated by the cannabinoid receptors, CB1 and CB2, which are G protein-coupled receptors (GPCRs). These receptors have been linked to a variety of physiological processes and are being pursued as prospective drug targets due to their potential in treating pain and inflammation.
Christina A. Brust, Matthew A. Swanson, Christos Iliopoulos Tsoutsouvas, Snezana T. Dimova, Vuong Q. Dang, Edward L. Stahl, Jo-Hao Ho, Spyros P. Nikas, Alexandros Makriyannis, Laura M. Bohn   +9 more
openaire   +2 more sources

Genetically Encoded CB₂R-Based Fluorescent Sensor Enables Rapid Screening and Functional Assessment of Cannabinoid Modulators. [PDF]

Int J Mol Sci
Bhattacharjee P, Volesky PD, Shivshankar S, Puhl H, Iyer MR.   +4 more
europepmc   +1 more source

Endocannabinoid Modulation in Headache: Mechanisms, Models, and Translational Therapies. [PDF]

Cells
Wen J, Zhang Y.
europepmc   +1 more source