Results 81 to 90 of about 562,936 (248)

Cannabidiol skews biased agonism at cannabinoid CB1 and CB2 receptors with smaller effect in CB1‐CB2 heteroreceptor complexes

Biochemical Pharmacology, 2018
Graphical abstract Figure. No Caption available. ABSTRACT Currently, biased agonism is at the center stage of drug development approaches. We analyzed effects of a battery of cannabinoids plus/minus cannabidiol (CBD) in four functional parameters (cAMP ...
Gemma Navarro, Irene Reyes-Resina, Rafael Rivas-Santisteban, Verónica Sánchez de Medina, P. Morales, S. Casano, C. Ferreiro-Vera, Alejandro Lillo, D. Aguinaga, N. Jagerovic, X. Nadal, R. Franco   +11 more
semanticscholar   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Signal detection and characterisation of a novel drug–drug interaction between methadone and a synthetic cannabinoid receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Little is known about how synthetic cannabinoid receptor agonist (SCRA) co‐use with other psychoactive substances may exacerbate risk of death. This study aimed to characterise the polypharmacy of deaths where SCRAs were detected at post‐mortem, investigate the cardiotoxicity of SCRAs and probe their inhibition of human ether‐a ...
Kirsten L. Rock, Louise M. Hesketh, Hongwei Cheng, Shuoqi Chen, Simon Hudson, Graeme Henderson, Jules C. Hancox, Michael J. Shattock, Michael J. Curtis, Caroline S. Copeland   +9 more
wiley   +1 more source

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

British Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli, Alessia Campagna, Barbara Eramo, Christian Sepe, Annarita Zuena, Silvana Gaetani, Adele Romano   +6 more
wiley   +1 more source

Cannabinoid Receptor Modulation in Focal Ischemic Stroke: A Systematic Review and Meta-Analysis of Infarct Volume and Behavioral Deficits in Animal Models

Medical Principles and Practice
Objective: This systematic review and meta-analysis aimed to evaluate the impact of cannabinoid (CB) receptor modulation on infarct volume and behavioral deficits in animal models of focal ischemic stroke, with a primary focus on infarct ...
Hussain Al Dera, Abdulrahman M. Khojah, Abdulrazak Sakhakhni, Shadell Alghamdi, Fahad Alsharef, Abdulaziz Alqahtani, Faisal Alamri, Syed Sameer Aga   +7 more
doaj   +1 more source

Differential effects of CB1 neutral antagonists and inverse agonists on gastrointestinal motility in mice

Neurogastroenterology and Motility, 2010
Background  Cannabinoid type 1 (CB1) receptors are involved in the regulation of gastrointestinal (GI) motility and secretion. Our aim was to characterize the roles of the CB1 receptor on GI motility and secretion in vitro and in vivo by using different ...
M. Storr, Mohammad Bashashati, C. Hirota, V. K. Vemuri, Catherine M. Keenan, Marnie Duncan, B. Lutz, Ken Mackie, Alexandros Makriyannis, Wallace K. MacNaughton, K. A. Sharkey   +10 more
semanticscholar   +1 more source

Protective effect of cannabinoid type 2 receptor agonist (JWH‐133) against hepatotoxicity induced by Prangos ferulacea Lindl. extract

Experimental Physiology, EarlyView.
Abstract This study investigated Prangos ferulacea (PF)‐induced hepatotoxicity, its potential association with endoplasmic reticulum (ER) stress and proinflammatory cytokines, and the effect of the cannabinoid type 2 receptor agonist JWH‐133. Rats (n = 37) were divided into four groups: control–sham group (CSG, n = 9), PF extract group (PG, n = 9), PF ...
Mesut Çelik, Aslı Çetin Taşlıdere, Zeynal Mete Karaca, Halil Düzova, İbrahim Halil Geçibesler, Ali Rıza Çalişkan, Çağatay Taşkapan, Kübranur Korkmaz   +7 more
wiley   +1 more source

Activation of cannabinoid type 2 (CB2) receptors promotes the maintenance of redox homeostasis and protects against oxidative distress in the Neotropical freshwater fish matrinxã Brycon amazonicus (Characiformes: Bryconidae) [PDF]

Neotropical Ichthyology
Recent evidence indicates significant interaction of cannabinoid receptors (CB1 and CB2) with redox mechanisms. This study investigated the effects of the cannabinoid agonists WIN 55,212-2 (CB1+CB2) and HU-308 (CB2) on oxidative biomarkers in the liver ...
Suzana Luisa Alves Fernandes, Yan Costa Gonçalves, Francisco Tadeu Rantin, Ana Lúcia Kalinin, Diana Amaral Monteiro   +4 more
doaj   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Antiaversive Effects of Cannabinoids: Is the Periaqueductal Gray Involved?

Neural Plasticity, 2009
Cannabinoids play an important role in activity-dependent changes in synaptic activity and can interfere in several brain functions, including responses to aversive stimuli.
F. A. Moreira, D. C. Aguiar, A. C. Campos, S. F. Lisboa, A. L. Terzian, L. B. Resstel, F. S. Guimarães   +6 more
doaj   +1 more source