Results 71 to 80 of about 10,682 (172)

Activation of cannabinoid type 2 (CB2) receptors promotes the maintenance of redox homeostasis and protects against oxidative distress in the Neotropical freshwater fish matrinxã Brycon amazonicus (Characiformes: Bryconidae) [PDF]

Neotropical Ichthyology
Recent evidence indicates significant interaction of cannabinoid receptors (CB1 and CB2) with redox mechanisms. This study investigated the effects of the cannabinoid agonists WIN 55,212-2 (CB1+CB2) and HU-308 (CB2) on oxidative biomarkers in the liver ...
Suzana Luisa Alves Fernandes, Yan Costa Gonçalves, Francisco Tadeu Rantin, Ana Lúcia Kalinin, Diana Amaral Monteiro   +4 more
doaj   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, Volume 183, Issue 9, Page 1747-1778, May 2026.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Review: “The Disappointment Dilemma: Short‐ and Long‐Term Learning From Negative Outcomes”

European Journal of Neuroscience, Volume 63, Issue 9, May 2026.
The habenula routes negative‐outcome signals to VTA, RMTg, and IPN to shape aversive learning and motivation. The lateral habenula encodes acute negative prediction errors to rapidly adapt behavior to threat, fear, and avoidance. The medial habenula integrates repeated stress, drug, and aversive experiences into long‐term negative mood and expectations.
Ines Ibañez‐Tallon, Susanna Molas, Christophe D. Proulx, Joaquin Piriz, Edgar Soria‐Gómez   +4 more
wiley   +1 more source

Antiaversive Effects of Cannabinoids: Is the Periaqueductal Gray Involved?

Neural Plasticity, 2009
Cannabinoids play an important role in activity-dependent changes in synaptic activity and can interfere in several brain functions, including responses to aversive stimuli.
F. A. Moreira, D. C. Aguiar, A. C. Campos, S. F. Lisboa, A. L. Terzian, L. B. Resstel, F. S. Guimarães   +6 more
doaj   +1 more source

Retraction Note: Crystal structures of agonist-bound human cannabinoid receptor CB₁. [PDF]

Nature
Hua T, Vemuri K, Nikas SP, Laprairie RB, Wu Y, Qu L, Pu M, Korde A, Jiang S, Ho JH, Han GW, Ding K, Li X, Liu H, Hanson MA, Zhao S, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ.   +19 more
europepmc   +2 more sources

Cannabinoid CB1 and CB2 Receptor-Mediated Arrestin Translocation: Species, Subtype, and Agonist-Dependence [PDF]

Frontiers in Pharmacology, 2019
Arrestin translocation and signaling have come to the fore of the G protein-coupled receptor molecular pharmacology field. Some receptor-arrestin interactions are relatively well understood and considered responsible for specific therapeutic or adverse outcomes.
Mikkel Søes Ibsen, Mikkel Søes Ibsen, David B. Finlay, Monica Patel, Monica Patel, Jonathan A. Javitch, Jonathan A. Javitch, Michelle Glass, Natasha Lillia Grimsey, Natasha Lillia Grimsey   +9 more
openaire   +3 more sources

Microvascular Effects of Endocannabinoid Signaling in Sepsis: A Mechanistic and Systematic Review

Microcirculation, Volume 33, Issue 4, May 2026.
ABSTRACT Microvascular dysfunction is a central determinant of organ failure in sepsis, reflecting early endothelial activation, increased permeability, and impaired capillary perfusion. Experimental evidence suggests that the endocannabinoid system (ECS) modulates these immunovascular processes, yet mechanistic insights remain dispersed across ...
Emanuel F. Matias, Francisco M. Vila‐Real, Maria A. Vieira‐Coelho   +2 more
wiley   +1 more source

Endocannabinoid modulation of cortical up-states and NREM sleep. [PDF]

PLoS ONE, 2014
Up-/down-state transitions are a form of network activity observed when sensory input into the cortex is diminished such as during non-REM sleep. Up-states emerge from coordinated signaling between glutamatergic and GABAergic synapses and are modulated ...
Matthew J Pava, Carolina R den Hartog, Carlos Blanco-Centurion, Priyattam J Shiromani, John J Woodward   +4 more
doaj   +1 more source

UK Medical Cannabis Registry: A Clinical Outcomes Analysis for Migraine

Brain and Behavior, Volume 16, Issue 4, April 2026.
This case series followed patients receiving medicinal cannabis for migraine headache for up to 2 years. At 24 months, there were significant improvements in measures assessing headache impact, anxiety, sleep quality, and general quality of life. Note that 15.27% of patients reported an adverse event, most of which were mild or moderate in severity ...
Lennon Hooper, Simon Erridge, Evonne Clarke, Katy McLachlan, Ross Coomber, Augustin Iqbal, James J. Rucker, Mark W. Weatherall, Mikael H. Sodergren   +8 more
wiley   +1 more source

Glucose concentration in culture medium affects mRNA expression of TRPV1 and CB1 receptors and changes capsaicin toxicity in PC12 cells [PDF]

Iranian Journal of Basic Medical Sciences, 2014
Objective (s):Hyperglycemia is widely recognized as the underlying cause for some debilitating conditions in diabetic patients. The role of cannabinoid CB1 and vanilloid TRPV1 receptors and their endogenous agonists, endovanilloids, in diabetic ...
Ahmad Mohammadi-Farani, Mahmoud Ghazi-Khansari, Mousa Sahebgharani   +2 more
doaj