Results 91 to 100 of about 1,257,507 (228)

β‐Caryophyllene Mitigates Thioacetamide‐Induced Liver Fibrosis Through CB2‐Mediated Suppression of Necroptosis: A Therapeutic Investigation

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
β‐Caryophyllene is a multifunctional sesquiterpene with significant therapeutic potential. Our findings demonstrate that β‐caryophyllene exerts broad hepatoprotective effects through the activation of cannabinoid type 2 (CB2) receptors. These effects include suppression of oxidative stress–induced injury, attenuation of inflammatory responses ...
Lujain Bader Eddin, Seenipandi Arunachalam, Loay Lubbad, Fayez T. Hammad, Ernest Adeghate, Sandeep Subramanya, Shreesh Ojha   +6 more
wiley   +1 more source

(+)‐Trans‐Cannabidiol Is an Agonist at Human CB2 Receptors

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT (−)‐trans‐Cannabidiol ((−)‐CBD) is a principal phytocannabinoid from Cannabis sativa. (−)‐CBD has complex pharmacology but is a relatively weak inhibitor of CB1 and CB2 receptor signaling. Cannabidiol has two chiral centres and thus four stereoisomers.
Pedro Bans Burtchaell, Marina Junqueira Santiago, Chenxi Wang, Mehdi Hagdoost, Evie J. M. Clay, Dani Mohnot, Mark Connor   +6 more
wiley   +1 more source

Efeito anti-hiperalgésico e antiinflamatório de triterpenos pentacíclicos em modelos experimentais de hiperalgesia crônica: participação do sistema canabinóide [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2011O presente estudo revela que o tratamento oral com os triterpenos pentacíclicos betulina (30 mg/mg ...
Silva, Kathryn Ana Bortolini Simão da
core  

Cannabinoid CB1 allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression

British Journal of Pharmacology, Volume 183, Issue 20, Page 6132-6153, October 2026.
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon, Sumanta Garai, Ganesh A. Thakur, Andrea G. Hohmann   +3 more
wiley   +1 more source

Lipoxina A4: um modulador alostérico endocanabinóide no sistema nervoso central [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciênicas Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2010Lipoxinas e endocanabinóides são eicosanóides endógenos que são liberados sob demanda em resposta à ...
Pamplona, Fabrício Alano
core  

High-resolution Immunoelectron Microscopy Techniques for Revealing Distinct Subcellular Type 1 Cannabinoid Receptor Domains in Brain

Bio-Protocol, 2019
Activation of type 1 cannabinoid (CB1) receptors by endogenous, exogenous (cannabis derivatives) or synthetic cannabinoids (i.e., CP 55.940, Win-2) has a wide variety of behavioral effects due to the presence of CB1 receptors in the brain.
Nagore Puente, Itziar Bonilla-Del Río, Svein Achicallende, Patrick Nahirney, Pedro Grandes   +4 more
doaj   +1 more source

Parvalbumin interneurons in Alzheimer's disease: Physiological insights and pathophysiological mechanisms

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Physiological and Pathological Alterations in PV+ Neurons: Under physiological conditions, PV+ interneurons exhibit fast‐spiking properties and generate gamma oscillations at the cost of high energy consumption. In AD, PV+ neurons display abnormalities in ion channels, dendrites, neurotransmission, energy metabolism, and neural oscillations, ultimately
Mengyan Wu, Xingdong Zeng, Yongle Cai, Haonan Chen, Qianying Li, Hao Yang   +5 more
wiley   +1 more source

NG2‐Glia in Central Nervous System Following Injury: From Pathological Involvement to Repair Potential

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Following CNS injury, NG2‐glia display distinct functional phases. In the early stage, NG2‐glia are rapidly activated, proliferate, migrate to the lesion site and secrete CSPGs, which form a chemical and physical barrier that inhibits axonal regeneration.
Yunyun Cai, Xin Shen, Ming Li, Junjie Li, Gang Chen   +4 more
wiley   +1 more source

Purification and characterization of heterologously produced cannabinoid receptor 1 and G proteins [PDF]

, 2007
G protein coupled receptors form the largest group of transmembrane proteins, which are involved in signal transduction and are targeted directly or indirectly by 40-50% of the drugs in the market.
Chillakuri, Chandramouli, Chillakuri, C.
core  

Cannabinoid‐Inspired Fluorescent Boroisoquinolines for CB1 Receptor Imaging

ChemPhotoChem, Volume 10, Issue 9, September 2026.
A cannabinoid‐inspired fluorescent boroisoquinoline, a low‐micromolar partial agonist of the human CB1 receptor, enabled imaging of CB1 receptors by confocal microscopy in live cells. The intrinsic fluorescence of our probe provides a unique opportunity for CB1 imaging while keeping receptor structure and pharmacology similar to that observed with ...
Dénes Szepesi Kovács, Csilla Nierner, Bettina Szepesi Kovács, Attila Lehotzky, Edina Szűcs, András Dávid Tóth, Dóra Judit Kiss, László Hunyady, György M. Keserű, Péter Ábrányi‐Balogh   +9 more
wiley   +1 more source