Results 121 to 130 of about 1,257,507 (228)

Neuroglial CB1 receptors modulate hippocampal processes in a sex-dependent manner

Biology of Sex Differences
Background Navigation and memory are hippocampal functions that are essential for survival. One of the key modulators of hippocampal activity is the endocannabinoid system through the cannabinoid receptor type 1 (CB1).
Jon Egaña-Huguet, Lucía Sangroniz-Beltrán, Andrés M. Baraibar, Pablo Reyes-Velásquez, Nicolas F. Landgraf, Paula Torres-Maldonado, Cathaysa Rodríguez-Cedrés, Francisca Julio-Kalajzic, Joaquín Piriz, Almudena Ramos, Pedro Grandes, Giovanni Marsicano, Susana Mato, María Ceprián, Edgar Soria-Gómez   +14 more
doaj   +1 more source

Coactivation of CB1 and GPR55 promotes GABA release and motor behavior at striatonigral terminals through increased dimerization induced by CB1 activation

Frontiers in Molecular Neuroscience
CB1 and GPR55 receptors form heteromers in striatal neurons; however, the effects of these heteromers on GABA release at their terminals and their impact on motor behavior remain unknown. In this study, we investigate the presence of CB1-GPR55 heteromers
José Arturo Avalos-Fuentes, Rodolfo Sánchez-Zavaleta, Ihosvany Rodríguez Pérez, Rafael Jijón-Lorenzo, Refugio Cruz-Trujillo, María Fernanda González de la Torre, Martha Abigail Villareal Zuñiga, Benjamín Florán   +7 more
doaj   +1 more source

Iso‐ and Benzisothiazolinone Inhibitors of Monoacylglycerol Lipase: Exploring On‐Target Activity Through Scaffold Decoration and In Situ Warhead Generation

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
We explore covalent allosteric targeting of MGL regulatory cysteines using iso‐ and benzisothiazolinone scaffolds. Combining mechanism‐based warhead release with structure‐guided scaffold decoration to improve molecular recognition, this study probes strategies to achieve selective on‐target engagement beyond the catalytic site. Monoacylglycerol lipase
Edoardo Rocca, Annalida Bedini, Laura Scalvini, Francesca Galvani, Riccardo Castelli, Lorenzo Sarcone, Adriano Recchia, Fabiola Fanini, Adren Tran, Silvia Rivara, Gilberto Spadoni, Daniele Piomelli, Marco Mor   +12 more
wiley   +1 more source

Administração de canabinóides no sistema nervoso central facilita a extinção de memórias aversivas em ratos [PDF]

, 2008
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.Recentemente, estudos têm demonstrado a capacidade do sistema endocanabinóide (eCB) em modular estados emocionais e ...
Bitencourt, Rafael Mariano de
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Design and synthesis of Heterocyclic Compounds as CB2 Selective Agoists [PDF]

, 2008
Cannabinoids are present in Indian hemp, Cannabis sativa L., and have been used since antiquity as medicinal agents(1). Interest in cannabinoid pharmacology has rapidly increased since the discovery of the endocannabinoid system (ECS), which includes ...
BENETTI, VERONICA
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Participação dos receptores canabinóides cerebrais na tolerância rápida e aguda do álcool [PDF]

, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.Evidências sugerem que o sistema de neurotransmissão endocanabinóide modula o consumo de álcool.
Carvalho, José Inácio Lemos Monteiro
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Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity

, 2011
Pharmacologic antagonism of cannabinoid 1 receptors (CB1 receptors) in the central nervous system (CNS) suppresses food intake, promotes weight loss, and improves the metabolic profile.
Hollenbeck, Thomas, Laura H. Jacobson, Sandra Teixeira, Anne-Liese Jaton, Chad Schwartzkopf, Chaperon, Frederique, Nguyen-Tran, Van, Xiaohui He, Sarah P. Gerber, Seidel, Martin, Thomas Hollenbeck, Chen, Alice, Schwartzkopf, Chad, Frederique Chaperon, H. Martin Seidel, Hong Liu, Peter McNamara, Teixeira, Sandra, Beatriz Dardik, Gerber, Sarah, Mcnamara, Peter, Van Nguyen-Tran, Yu Alice Chen, Liu, Hong, Commerford, Susan, Jesper Gromada, Gromada, Jesper, Dardik, Beatriz, He, Xiaohui, Jaton, Anne-Lise, S. Renee Commerford   +30 more
core   +1 more source

CB1 Receptor Antagonist AM-251: Effect on Spatial Memory in Male Mice

, 2009
\ud CB1 RECEPTOR ANTAGONIST AM-251: EFFECT\ud ON SPATIAL MEMORY IN MALE MICE\ud by\ud Brannon Micheal Green\ud Master of Arts in Psychology\ud Psychological Science Option\ud California State University, Chico\ud Summer 2009\ud The current study ...
Green, Brannon
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Cannabinoid CB1 receptor (CNR1) [PDF]

Science-Business eXchange, 2009
  +7 more sources

CB1 cannabinoid receptorok megoszlásának vizsgálata a gerincvelő felületes hátsó szarvában

, 2009
A gerincvelő felületes hátsó szarvában kimutatható CB1 receptorok mind primer afferensek, mint gátló és serkentő geincvelői interneuronok axonterminálisan jelentős mértékben expresszálódnak. A korábbi elektrofiziológiai vizsgálatokkal összhangban ezek az
Pálóczi, János
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