Results 11 to 20 of about 21,385 (196)
CB1 Cannabinoid Receptor Signaling and Biased Signaling
Molecules, 2021 The CB1 cannabinoid receptor is a G-protein coupled receptor highly expressed throughout the central nervous system that is a promising target for the treatment of various disorders, including anxiety, pain, and neurodegeneration.
Luciana M. Leo, Mary E. Abood
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Frontiers in Neuroanatomy, 2022 Adult oligodendrocyte progenitor cells (OPCs) give rise to myelinating oligodendrocytes through life and play crucial roles in brain homeostasis and plasticity during health and disease.
Andrea Manterola +18 more
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Cannabinoid CB1 receptors regulate salivation
Scientific Reports, 2022 AbstractSaliva serves multiple important functions within the body that we typically take for granted, such as helping prepare food for swallowing and defense against oral pathogens. Dry mouth is a primary symptom of Sjӧgren’s syndrome and is a side effect of many drug treatments.
Kelsey Andreis +6 more
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Frontiers in Neuroanatomy, 2022 The present study describes a detailed neuroanatomical distribution map of the cannabinoid type 1 (CB1) receptor, along with the biochemical characterization of the expression and functional coupling to their cognate Gi/o proteins in the medial ...
Leyre Echeazarra +27 more
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The Orphan Nuclear Receptor ERRγ Regulates Hepatic CB1 Receptor-Mediated Fibroblast Growth Factor 21 Gene Expression. [PDF]
PLoS ONE, 2016 Fibroblast growth factor 21 (FGF21), a stress inducible hepatokine, is synthesized in the liver and plays important roles in glucose and lipid metabolism.
Yoon Seok Jung +14 more
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Probing the Interaction of SR141716A with the CB1 Receptor [PDF]
Journal of Biological Chemistry, 2012 SR141716A binds selectively to the brain cannabinoid (CB1) receptor and exhibits a potent inverse agonist/antagonist activity. Although SR141716A, also known as rimonabant, has been withdrawn from the market due to severe side effects, there remains interest in some of its many potential medical applications.
Joong-Youn, Shim +2 more
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An enquiry to the role of CB1 receptors in neurodegeneration
Neurobiology of Disease, 2023 Neurodegenerative disorders are debilitating conditions that impair patient quality of life and that represent heavy social-economic burdens to society. Whereas the root of some of these brain illnesses lies in autosomal inheritance, the origin of most of these neuropathologies is scantly understood.
Fernandez-Moncada, Ignacio +4 more
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Frontiers in Neuroanatomy, 2021 The transient receptor potential vanilloid 1 (TRPV1) participates in synaptic functions in the brain. In the dentate gyrus, post-synaptic TRPV1 in the granule cell (GC) dendritic spines mediates a type of long-term depression (LTD) of the excitatory ...
Jon Egaña-Huguet +25 more
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Structural basis for activation of CB1 by an endocannabinoid analog
Nature Communications, 2023 Endocannabinoids (eCBs) are endogenous ligands of the cannabinoid receptor 1 (CB1), a G protein-coupled receptor that regulates a number of therapeutically relevant physiological responses.
Kaavya Krishna Kumar +12 more
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PLoS ONE, 2011 It is well known that acute challenges with psychostimulants such as amphetamine affect impulsive behavior. We here studied the pharmacology underlying the effects of amphetamine in two rat models of impulsivity, the 5-choice serial reaction time task (5-
Joost Wiskerke +4 more
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