Results 21 to 30 of about 21,385 (196)
The Cannabinoid Receptor CB1 Interacts with the WAVE1 Complex and Plays a Role in Actin Dynamics and Structural Plasticity in Neurons. [PDF]
PLoS Biology, 2015 The molecular composition of the cannabinoid type 1 (CB1) receptor complex beyond the classical G-protein signaling components is not known. Using proteomics on mouse cortex in vivo, we pulled down proteins interacting with CB1 in neurons and show that ...
Christian Njoo +3 more
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Frontiers in Pharmacology, 2022 Cannabidiol (CBD), the major non-psychoactive phytocannabinoid present in the plant Cannabis sativa, has displayed beneficial pharmacological effects in the treatment of several neurological disorders including, epilepsy, Parkinson’s disease, and ...
Eliud Morales Dávila +7 more
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Cells, 2022 In this study, we investigated the cross-talk between mGlu1 and CB1 receptors in modulating GABA hippocampal output in whole-cell voltage clamp recordings in rat hippocampal acute slices, in organotypic hippocampal slices exposed to oxygen and glucose ...
Elisa Landucci +6 more
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Signal transduction of the CB1 cannabinoid receptor [PDF]
Journal of Molecular Endocrinology, 2009 The CB1 cannabinoid receptor (CB1R) is the major cannabinoid receptor in neuronal cells and the brain, but it also occurs in endocrine cells and other peripheral tissues. CB1R is a member of the superfamily of G-protein-coupled receptors (GPCRs), which are characterized by seven transmembrane helices.
Gábor, Turu, László, Hunyady
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Frontiers in Pharmacology, 2019 Alterations of the PI3K/Akt/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway are causally involved in a subset of malformations of cortical development (MCDs) ranging from focal cortical dysplasia (FCD) to hemimegalencephaly and ...
Daniel García-Rincón +21 more
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Neurobiology of Disease, 2005 We have observed that systemic administration of cannabinoid CB1 antagonists exerts antiparkinsonian effects in rats with very severe nigral lesion (>95% cell loss), but not in rats with less severe lesion (85–95% cell loss).
Emilio Fernandez-Espejo +6 more
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Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke
Pharmaceuticals, 2010 Cannabis contains the psychoactive component delta9-tetrahydrocannabinol (delta9-THC), and the non-psychoactive components cannabidiol (CBD), cannabinol, and cannabigerol.
Michihiro Fujiwara +2 more
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Circuit specific functions of cannabinoid CB1 receptor in the balance of investigatory drive and exploration. [PDF]
PLoS ONE, 2011 Well balanced novelty seeking and exploration are fundamental behaviours for survival and are found to be dysfunctional in several psychiatric disorders.
Martin Häring +3 more
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Hippocampal CB1 Receptors Control Incidental Associations [PDF]
Neuron, 2018 By priming brain circuits, associations between low-salience stimuli often guide future behavioral choices through a process known as mediated or inferred learning. However, the precise neurobiological mechanisms of these incidental associations are largely unknown.
Busquets-Garcia, Arnau +15 more
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