Results 31 to 40 of about 21,385 (196)

Cardiorespiratory anomalies in mice lacking CB1 cannabinoid receptors. [PDF]

PLoS ONE, 2014
Cannabinoid type 1 (CB1) receptors are expressed in the nervous and cardiovascular systems. In mice, CB1 receptor deficiency protects from metabolic consequences of a high-fat diet (HFD), increases sympathetic activity to brown fat, and entails sleep ...
Alessandro Silvani, Chiara Berteotti, Stefano Bastianini, Gary Cohen, Viviana Lo Martire, Roberta Mazza, Uberto Pagotto, Carmelo Quarta, Giovanna Zoccoli   +8 more
doaj   +1 more source

CB1 cannabinoid receptor expression in the striatum: Association with corticostriatal circuits and developmental regulation

Frontiers in Pharmacology, 2012
Corticostriatal circuits mediate various aspects of goal-directed behavior and are critically important for basal ganglia-related disorders. Activity in these circuits is regulated by the endocannabinoid system via stimulation of CB1 cannabinoid ...
Vincent eVan Waes, Joel eBeverley, Homayoun eSiman, Kuei Y. eTseng, Heinz eSteiner   +4 more
doaj   +1 more source

The role of cannabinoid CB1 receptors in the antinociceptive and reparative actions of mesenchymal stem cells in rats with peripheral neuropathic pain

Ibrain, 2023
Mesenchymal stem cells (MSCs) can produce antinociceptive and reparative effects. Presumably, the MSCs‐induced antinociception may be partly due to the involvement of the endocannabinoid system.
Anna‐Maria V. Yerofeyeva, Sergey V. Pinchuk, Svetlana N. Rjabceva, Alla Y. Molchanova   +3 more
doaj   +1 more source

Effects of inflammatory pain on CB1 receptor in the midbrain periaqueductal gray

PAIN Reports, 2021
. Introduction:. The periaqueductal gray (PAG) mediates the antinociceptive properties of analgesics, including opioids and cannabinoids. Administration of either opioids or cannabinoids into the PAG induces antinociception.
Adrianne R. Wilson-Poe, Beth Wiese, Cherkaouia Kibaly, Lindsay Lueptow, Jeniffer Garcia, Preeti Anand, Catherine Cahill, Jose A. Morón   +7 more
doaj   +1 more source

Cannabinoid type-1 receptor signaling in central serotonergic neurons regulates anxiety-like behavior and sociability

Frontiers in Behavioral Neuroscience, 2015
The endocannabinoid system possesses neuromodulatory functions by influencing the release of various neurotransmitters, including γ-aminobutyric acid (GABA) and glutamate.
Beat eLutz, Martin eHäring, Vanessa eEnk, Alejandro eAparisi Rey, Sebastian eLoch, Inigo eRuiz De Azua, Krisztina eMonory, Tillmann eWeber, Dusan eBartsch   +8 more
doaj   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

MD Simulations Revealing Special Activation Mechanism of Cannabinoid Receptor 1

Frontiers in Molecular Biosciences, 2022
Cannabinoid receptor 1 (CB1) is a G protein-coupled receptor (GPCR) that is gaining much interest for its regulating role in the central nervous system and its value as a drug target.
Yiran Wu, Xuanxuan Li, Tian Hua, Tian Hua, Zhi-Jie Liu, Zhi-Jie Liu, Haiguang Liu, Suwen Zhao, Suwen Zhao   +8 more
doaj   +1 more source

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

Autism Research, EarlyView.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin, Arthur N. Westover, Amy S. F. Lutz, Manish K. Jha   +3 more
wiley   +1 more source

Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis

Cell Communication and Signaling, 2010
Background Adult neurogenesis is a particular example of brain plasticity that is partially modulated by the endocannabinoid system. Whereas the impact of synthetic cannabinoids on the neuronal progenitor cells has been described, there has been lack of ...
Müller Anke, Tauber Svantje, Ramirez-Rodriguez Gerardo, Leal-Galicia Perla, Fabel Klaus, Bick-Sander Anika, Wolf Susanne A, Melnik Andre, Waltinger Tim P, Ullrich Oliver, Kempermann Gerd   +10 more
doaj   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source