Results 31 to 40 of about 1,257,507 (228)

Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke

Pharmaceuticals, 2010
Cannabis contains the psychoactive component delta9-tetrahydrocannabinol (delta9-THC), and the non-psychoactive components cannabidiol (CBD), cannabinol, and cannabigerol.
Michihiro Fujiwara, Kazuhide Hayakawa, Kenichi Mishima   +2 more
doaj   +1 more source

Cannabinoid CB1 antagonists possess antiparkinsonian efficacy only in rats with very severe nigral lesion in experimental parkinsonism

Neurobiology of Disease, 2005
We have observed that systemic administration of cannabinoid CB1 antagonists exerts antiparkinsonian effects in rats with very severe nigral lesion (>95% cell loss), but not in rats with less severe lesion (85–95% cell loss).
Emilio Fernandez-Espejo, Isabel Caraballo, Fernando Rodriguez de Fonseca, Fadwa El Banoua, Belen Ferrer, Juan A. Flores, Beatriz Galan-Rodriguez   +6 more
doaj   +1 more source

Circuit specific functions of cannabinoid CB1 receptor in the balance of investigatory drive and exploration. [PDF]

PLoS ONE, 2011
Well balanced novelty seeking and exploration are fundamental behaviours for survival and are found to be dysfunctional in several psychiatric disorders.
Martin Häring, Nadine Kaiser, Krisztina Monory, Beat Lutz   +3 more
doaj   +1 more source

Cannabinoid CB1 receptor [PDF]

Science-Business eXchange, 2008
  +12 more sources

Cardiorespiratory anomalies in mice lacking CB1 cannabinoid receptors. [PDF]

PLoS ONE, 2014
Cannabinoid type 1 (CB1) receptors are expressed in the nervous and cardiovascular systems. In mice, CB1 receptor deficiency protects from metabolic consequences of a high-fat diet (HFD), increases sympathetic activity to brown fat, and entails sleep ...
Alessandro Silvani, Chiara Berteotti, Stefano Bastianini, Gary Cohen, Viviana Lo Martire, Roberta Mazza, Uberto Pagotto, Carmelo Quarta, Giovanna Zoccoli   +8 more
doaj   +1 more source

Signal transduction of the CB1 cannabinoid receptor [PDF]

Journal of Molecular Endocrinology, 2009
The CB 1 cannabinoid receptor (CB 1 R) is the major cannabinoid receptor in neuronal cells and the brain, but it also occurs in endocrine cells and other peripheral tissues.
Gábor, Turu, László, Hunyady
openaire   +2 more sources

CB1 cannabinoid receptor expression in the striatum: Association with corticostriatal circuits and developmental regulation

Frontiers in Pharmacology, 2012
Corticostriatal circuits mediate various aspects of goal-directed behavior and are critically important for basal ganglia-related disorders. Activity in these circuits is regulated by the endocannabinoid system via stimulation of CB1 cannabinoid ...
Vincent eVan Waes, Joel eBeverley, Homayoun eSiman, Kuei Y. eTseng, Heinz eSteiner   +4 more
doaj   +1 more source

The role of cannabinoid CB1 receptors in the antinociceptive and reparative actions of mesenchymal stem cells in rats with peripheral neuropathic pain

Ibrain, 2023
Mesenchymal stem cells (MSCs) can produce antinociceptive and reparative effects. Presumably, the MSCs‐induced antinociception may be partly due to the involvement of the endocannabinoid system.
Anna‐Maria V. Yerofeyeva, Sergey V. Pinchuk, Svetlana N. Rjabceva, Alla Y. Molchanova   +3 more
doaj   +1 more source

Effects of inflammatory pain on CB1 receptor in the midbrain periaqueductal gray

PAIN Reports, 2021
. Introduction:. The periaqueductal gray (PAG) mediates the antinociceptive properties of analgesics, including opioids and cannabinoids. Administration of either opioids or cannabinoids into the PAG induces antinociception.
Adrianne R. Wilson-Poe, Beth Wiese, Cherkaouia Kibaly, Lindsay Lueptow, Jeniffer Garcia, Preeti Anand, Catherine Cahill, Jose A. Morón   +7 more
doaj   +1 more source

Cannabinoid type-1 receptor signaling in central serotonergic neurons regulates anxiety-like behavior and sociability

Frontiers in Behavioral Neuroscience, 2015
The endocannabinoid system possesses neuromodulatory functions by influencing the release of various neurotransmitters, including γ-aminobutyric acid (GABA) and glutamate.
Beat eLutz, Martin eHäring, Vanessa eEnk, Alejandro eAparisi Rey, Sebastian eLoch, Inigo eRuiz De Azua, Krisztina eMonory, Tillmann eWeber, Dusan eBartsch   +8 more
doaj   +1 more source