Results 11 to 20 of about 19,856 (171)

Role of endocannabinoid CB1 receptors in Streptozotocin-induced uninephrectomised Wistar rats in diabetic nephropathy

Beni-Suef University Journal of Basic and Applied Sciences, 2021
Background The endocannabinoid CB1 receptor is known to have protective effects in kidney disease. The aim of the present study is to evaluate the potential agonistic and antagonistic actions and to determine the renoprotective potential of CB1 receptors
Jayarami Reddy Medapati, Deepthi Rapaka, Veera Raghavulu Bitra, Santhosh Kumar Ranajit, Girija Sankar Guntuku, Annapurna Akula   +5 more
doaj   +1 more source

Up-regulation of CB1 cannabinoid receptors located at glutamatergic terminals in the medial prefrontal cortex of the obese Zucker rat

Frontiers in Neuroanatomy, 2022
The present study describes a detailed neuroanatomical distribution map of the cannabinoid type 1 (CB1) receptor, along with the biochemical characterization of the expression and functional coupling to their cognate Gi/o proteins in the medial ...
Leyre Echeazarra, Leyre Echeazarra, Sergio Barrondo, Sergio Barrondo, Sergio Barrondo, Gontzal García del Caño, Gontzal García del Caño, Itziar Bonilla-Del Río, Itziar Bonilla-Del Río, Jon Egaña-Huguet, Jon Egaña-Huguet, Nagore Puente, Nagore Puente, Xabier Aretxabala, Mario Montaña, Maider López de Jesús, Maider López de Jesús, Imanol González-Burguera, Imanol González-Burguera, Miquel Saumell-Esnaola, Miquel Saumell-Esnaola, María Aránzazu Goicolea, Pedro Grandes, Pedro Grandes, Pedro Grandes, Joan Sallés, Joan Sallés, Joan Sallés   +27 more
doaj   +1 more source

Hippocampal CB1 Receptors Control Incidental Associations [PDF]

Neuron, 2018
By priming brain circuits, associations between low-salience stimuli often guide future behavioral choices through a process known as mediated or inferred learning. However, the precise neurobiological mechanisms of these incidental associations are largely unknown.
Busquets-Garcia, Arnau, Oliveira da Cruz, José F., Terral, Geoffrey, Zottola, Antonio C. Pagano, Soria-Gomez, Edgar, Contini, Andrea, Martin, Hugo, Redon, Bastien, Varilh, Marjorie, Ioannidou, Christina, Drago, Filippo, Massa, Federico, Fioramonti, Xavier, Trifilieff, Pierre, Ferreira, Guillaume, Marsicano, Giovanni   +15 more
openaire   +5 more sources

The Interplay between the Immune and the Endocannabinoid Systems in Cancer

Cells, 2021
The therapeutic potential of Cannabis sativa has been recognized since ancient times. Phytocannabinoids, endocannabinoids and synthetic cannabinoids activate two major G protein-coupled receptors, subtype 1 and 2 (CB1 and CB2).
Mariantonia Braile, Simone Marcella, Gianni Marone, Maria Rosaria Galdiero, Gilda Varricchi, Stefania Loffredo   +5 more
doaj   +1 more source

High-resolution Immunoelectron Microscopy Techniques for Revealing Distinct Subcellular Type 1 Cannabinoid Receptor Domains in Brain

Bio-Protocol, 2019
Activation of type 1 cannabinoid (CB1) receptors by endogenous, exogenous (cannabis derivatives) or synthetic cannabinoids (i.e., CP 55.940, Win-2) has a wide variety of behavioral effects due to the presence of CB1 receptors in the brain.
Nagore Puente, Itziar Bonilla-Del Río, Svein Achicallende, Patrick Nahirney, Pedro Grandes   +4 more
doaj   +1 more source

Cannabinoid CB1 receptor [PDF]

Science-Business eXchange, 2008
  +12 more sources

Cannabinoid type 1 and type 2 receptor antagonists prevent attenuation of serotonin-induced reflex apneas by dronabinol in Sprague-Dawley rats. [PDF]

PLoS ONE, 2014
The prevalence of obstructive sleep apnea (OSA) in Americans is 9% and increasing. Increased afferent vagal activation may predispose to OSA by reducing upper airway muscle activation/patency and disrupting respiratory rhythmogenesis.
Michael W Calik, David W Carley
doaj   +1 more source

CB1 cannabinoid receptor expression in the striatum: Association with corticostriatal circuits and developmental regulation

Frontiers in Pharmacology, 2012
Corticostriatal circuits mediate various aspects of goal-directed behavior and are critically important for basal ganglia-related disorders. Activity in these circuits is regulated by the endocannabinoid system via stimulation of CB1 cannabinoid ...
Vincent eVan Waes, Joel eBeverley, Homayoun eSiman, Kuei Y. eTseng, Heinz eSteiner   +4 more
doaj   +1 more source

Lack of the Transient Receptor Potential Vanilloid 1 Shifts Cannabinoid-Dependent Excitatory Synaptic Plasticity in the Dentate Gyrus of the Mouse Brain Hippocampus

Frontiers in Neuroanatomy, 2021
The transient receptor potential vanilloid 1 (TRPV1) participates in synaptic functions in the brain. In the dentate gyrus, post-synaptic TRPV1 in the granule cell (GC) dendritic spines mediates a type of long-term depression (LTD) of the excitatory ...
Jon Egaña-Huguet, Jon Egaña-Huguet, Miquel Saumell-Esnaola, Miquel Saumell-Esnaola, Svein Achicallende, Svein Achicallende, Edgar Soria-Gomez, Edgar Soria-Gomez, Edgar Soria-Gomez, Itziar Bonilla-Del Río, Itziar Bonilla-Del Río, Gontzal García del Caño, Gontzal García del Caño, Sergio Barrondo, Sergio Barrondo, Joan Sallés, Joan Sallés, Inmaculada Gerrikagoitia, Inmaculada Gerrikagoitia, Nagore Puente, Nagore Puente, Izaskun Elezgarai, Izaskun Elezgarai, Pedro Grandes, Pedro Grandes, Pedro Grandes   +25 more
doaj   +1 more source

Cannabinoid CB1 receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in mice

Cell Death and Disease, 2022
Cannabinoids are known to modulate oligodendrogenesis and developmental CNS myelination. However, the cell-autonomous action of these compounds on oligodendroglial cells in vivo, and the molecular mechanisms underlying these effects have not yet been ...
Aníbal Sánchez-de la Torre, Tania Aguado, Alba Huerga-Gómez, Silvia Santamaría, Antonietta Gentile, Juan Carlos Chara, Carlos Matute, Krisztina Monory, Susana Mato, Manuel Guzmán, Beat Lutz, Ismael Galve-Roperh, Javier Palazuelos   +12 more
doaj   +1 more source