Results 71 to 80 of about 129,465 (297)

Identifying chemokines as therapeutic targets in renal disease: Lessons from antagonist studies and knockout mice [PDF]

, 2004
Chemokines, in concert with cytokines and adhesion molecules, play multiple roles in local and systemic immune responses. In the kidney, the temporal and spatial expression of chemokines correlates with local renal damage and accumulation of chemokine ...
Abdi R, Anders HJ, Anders HJ, Anders HJ, Bruhl H, Burne-Taney MJ, Feng L, Fituri O, Fujinaka H, Garcia GE, Grone HJ, Keane MP, Mack M, Miura M, Murphy PM, Nath KA, Perez de Lema G, Rollins BJ, Romagnani P, Segerer S, Segerer S, Segerer S, Tang WW, Taub DD, Tesch GH, Tokuda A, Topham PS, Vielhauer V, Vielhauer V, Wada T, Wang Y, Wenzel U, Wu X, Wu X, Zernecke A   +34 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Ccl2 and Ccl3 Mediate Neutrophil Recruitment via Induction of Protein Synthesis and Generation of Lipid Mediators [PDF]

, 2009
Objective: Although the chemokines monocyte chemoattractant protein-1 (Ccl2/JE/MCP-1) and macrophage inflammatory protein-1α (Ccl3/MIP-1α) have recently been implicated in neutrophil migration, the underlying mechanisms remain largely unclear.
Berberich, Nina, Bihari, Peter, Khandoga, Alexander G., Krombach, Fritz, Lerchenberger, Max, Rehberg, Markus, Reichel, Christoph A., Zahler, Stefan   +7 more
core   +1 more source

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

Corneal and Conjunctival Fibroblasts Are Major Sources of Eosinophil-Recruiting Chemokines

Allergology International, 2009
Background: Differential expression of chemokine genes were investigated in various types of ocular surface cells. Methods: Primary cultures of human corneal epithelial cells (n = 3), corneal fibroblasts (n = 2), conjunctival epithelial cells (n = 2) and
Kazumi Fukagawa, Naoko Okada, Hiroshi Fujishima, Toshiharu Nakajima, Yoji Takano, Mari Tanaka, Murat Dogru, Yoshiyuki Satake, Kazuo Tsubota, Hirohisa Saito   +9 more
doaj   +1 more source

A decline in CCL3-5 chemokine gene expression during primary simian-human immunodeficiency virus infection. [PDF]

PLoS ONE, 2007
The CC-chemokines CCL3, CCL4 and CCL5 have been found to block the entry of CCR5-tropic HIV into host cells and to suppress the viral replication in vitro, but the in vivo role of endogenous CC-chemokines in HIV-1 infection is still incompletely ...
Wei Zhao, Bapi Pahar, Juan T Borda, Xavier Alvarez, Karol Sestak   +4 more
doaj   +1 more source

Cytomegalovirus CC Chemokine Promotes Immune Cell Migration [PDF]

Journal of Virology, 2012
ABSTRACT Cytomegaloviruses manipulate the host chemokine/receptor axis by altering cellular chemokine expression and by encoding multiple chemokines and chemokine receptors. Similar to human cytomegalovirus (HCMV), rat cytomegalovirus (RCMV) encodes multiple CC chemokine-analogous proteins, including r129 (HCMV UL128 homologue ...
Totonchy, Jennifer, Denton, Michael, Kreklywich, Craig N., Andoh, Takeshi, Osborn, Jessica M., Chen, Daniel, Messaoudi, Ilhem, Orloff, Susan L., Streblow, Daniel N.   +8 more
openaire   +3 more sources

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

The role of chemokines in Schistosoma mansoni infection: insights from human disease and murine models

Memorias do Instituto Oswaldo Cruz, 2006
Chemokines are a superfamily of low-molecular-weight cytokines that were initially described for their chemoattractant activity. It is now clear chemokines have several other activities that modulate immune processes.
Adriano LS Souza, Silvio R Sousa-Pereira, Mauro M Teixeira, José R Lambertucci, Antonio L Teixeira   +4 more
doaj   +1 more source

Phenotyping renal leukocyte subsets by four-color flow cytometry: Characterization of chemokine receptor expression [PDF]

, 2003
To investigate mechanisms of cell-mediated injury in renal inflammatory disease it is critical to determine the surface phenotype of infiltrating renal leukocyte subsets.
Anders, Hans-Joachim, de Lema, Guillermo Pérez, Luckow, Bruno, Mack, Matthias, Schlöndorff, Detlef, Vielhauer, Volker   +5 more
core   +1 more source