Results 91 to 100 of about 4,301 (202)

Neutralizing Antibodies against Crimean–Congo Hemorrhagic Fever Virus Derived from a Human Survivor

Proceedings, 2020
Crimean–Congo hemorrhagic fever virus (CCHFV) is an arbovirus belonging to the Nairoviridae family. The virus, as well as ticks of the Hyalomma genus, which serve as its reservoir host, are found in parts of Africa, western Asia, and southern Europe ...
J. Maximilian Fels, Daniel Maurer, Ana I. Kuehne, Dafna M. Abelson, Noel T. Pauli, Andrew S. Herbert, John M. Dye, Robert W. Cross, Thomas W. Geisbert, Leslie Lobel, Zachary A. Bornholdt, Laura M. Walker, Kartik Chandran   +12 more
doaj   +1 more source

Evaluation of a Luminex‐Based Multiplex Immunoassay of Hemorrhagic Fever Viruses in Senegal

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Given the growing threat posed by viral hemorrhagic fevers, the development of surveillance tools is crucial to provide accurate and rapid solutions. Public health response involves risk assessment as well as effective and sustainable surveillance to ensure downstream communication and preparedness. A serological approach that offers high precision and
Safietou Sankhe, Maryam Diarra, Mamadou Aliou Barry, Martin Faye, Cheikh Talla, Diogop Camara, Maimouna Mbanne, Pape Mbacke Sembene, Amadou Alpha Sall, Gamou Fall, Oumar Faye, Cheikh Loucoubar, Ousmane Faye, Ines Vigan-Womas, Keersten Michelle Ricks, Jessica Radzio-Basu, Moussa Moise Diagne, Leyi Wang   +17 more
wiley   +1 more source

HuR (ELAVL1) regulates the CCHFV minigenome and HAZV replication by associating with viral genomic RNA

PLOS Neglected Tropical Diseases
Crimean-Congo Hemorrhagic Fever virus (CCHFV) is a tick-borne pathogen that causes severe acute fever disease in humans and requires a biosafety level 4 laboratory for handling. Hazara virus (HAZV), belonging to the same virus genus as CCHFV, does not exhibit pathogenesis in humans.
Moe Ikegawa, Norisuke Kano, Daisuke Ori, Mizuki Fukuta, Minato Hirano, Roger Hewson, Kentaro Yoshii, Taro Kawai, Takumi Kawasaki   +8 more
openaire   +3 more sources

Epidemiologic Survey of Crimean-Congo Hemorrhagic Fever Virus in Suids, Spain

Emerging Infectious Diseases
We conducted a cross-sectional study in wild boar and extensively managed Iberian pig populations in a hotspot area of Crimean-Congo hemorrhagic fever virus (CCHFV) in Spain. We tested for antibodies against CCHFV by using 2 ELISAs in parallel.
Mario Frías, Kerstin Fischer, Sabrina Castro-Scholten, Caroline Bost, David Cano-Terriza, Maria Ángeles Risalde, Pelayo Acevedo, Saúl Jiménez-Ruiz, Balal Sadeghi, Martin H. Groschup, Javier Caballero-Gómez, Ignacio García-Bocanegra   +11 more
doaj   +1 more source

Stable Occupancy of the Crimean-Congo Hemorrhagic Fever Virus-Encoded Deubiquitinase Blocks Viral Infection

mBio, 2019
Crimean-Congo hemorrhagic fever virus (CCHFV) infection can result in a severe hemorrhagic syndrome for which there are no antiviral interventions available to date. Certain RNA viruses, such as CCHFV, encode cysteine proteases of the ovarian tumor (OTU)
Florine E. M. Scholte, Brian L. Hua, Jessica R. Spengler, John V. Dzimianski, JoAnn D. Coleman-McCray, Stephen R. Welch, Laura K. McMullan, Stuart T. Nichol, Scott D. Pegan, Christina F. Spiropoulou, Éric Bergeron   +10 more
doaj   +1 more source

Interferon-stimulated gene (ISG)-expression screening reveals the specific antibunyaviral activity of ISG20 [PDF]

, 2018
Bunyaviruses pose a significant threat to human health, prosperity and food security. In response to viral infections, interferons (IFNs) upregulate the expression of hundreds of interferon stimulated genes (ISGs) whose cumulative action can potently ...
Bieniasz, Paul D., Brennan, Benjamin, Elliott, Richard M., Feng, Junjie, Koudriakova, Elina, Kreher, Felix, Rezelj, Veronica V., Rice, Charles M., Rihn, Suzannah J., Shaw, Andrew E., Shi, Xiaohong, Slack, Gillian S., Tilston-Lunel, Natasha L., Turnbull, Matthew L., Wickenhagen, Arthur, Wilson, Sam J.   +15 more
core   +1 more source

Hyalomma marginatum in Europe: The Past, Current Status, and Future Challenges—A Systematic Review

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Hyalomma marginatum is a prominent tick vector responsible for transmitting various pathogens, including the Crimean–Congo hemorrhagic fever virus (CCHFV), across Europe. This systematic review consolidates findings from 144 publications regarding the geographical distribution of H. marginatum and its associated pathogens.
Seyma S. Celina, Jiří Černý, Zongfu Wu   +2 more
wiley   +1 more source

Biosurveillance in Central Asia: Successes and Challenges of Tick-Borne Disease Research in Kazakhstan and Kyrgyzstan [PDF]

, 2016
Central Asia is a vast geographic region that includes five former Soviet Union republics: Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan, and Uzbekistan.
Alexei Andryushchenko, Allen L. Richards, Asankadyr Zhunushov, Christina M. Farris, Debanjana Dasgupta, Gulnara Omasheva, John Hay, Kenneth B. Yeh, Pavel Deryabin, Roger Hewson, Talgat Nurmakhanov, Timur Ayazbayev, Zhanna Shapieva   +12 more
core   +2 more sources

Metatranscriptomic Analysis Uncovers RNA Virus Diversity in Ticks From the China–Russia–North Korea Border Region

Transboundary and Emerging Diseases, Volume 2025, Issue 1, 2025.
Ticks serve as critical viral vectors, and border regions, acting as convergence zones of complex ecosystems, provide diverse habitats for ticks and their hosts, thereby underscoring the need to investigate the tick‐borne virome composition in such areas. In this study, metatranscriptomic analysis of five tick species, namely Haemaphysalis longicornis,
Zhe Liu, Shengwei Ji, Jinqi Wang, Yuan Li, Eloiza May Galon, Shanshan Wang, Jixu Li, Xu Gao, Longzheng Yu, Yang Wang, Jianchen Song, Qichao Cui, Chenghui Li, Zhiqiang Xu, Shujiang Xue, Kamani Joshua   +15 more
wiley   +1 more source

Development of targeted whole genome sequencing approaches for Crimean-Congo haemorrhagic fever virus (CCHFV)

Virus Research
Crimean-Congo haemorrhagic fever (CCHF) is the most prevalent human tick-borne viral disease, with a reported case fatality rate of 30 % or higher. The virus contains a tri-segmented, negative-sense RNA genome consisting of the small (S), medium (M) and large (L) segments encoding respectively the nucleoprotein (NP), the glycoproteins precursor (GPC ...
Jake D'Addiego, Sonal Shah, Ayşe Nur Pektaş, Bi̇nnur Köksal Bağci, Murtaza Öz, Sasha Sebastianelli, Nazif Elaldı, David J Allen, Roger Hewson   +8 more
openaire   +3 more sources