Results 111 to 120 of about 3,609 (205)

The CD8+T cells response is sufficient for protection with a CCHFV M-segment based DNA vaccine and GP38 enhances vaccine immunogenicity

International Journal of Infectious Diseases
Introduction: Crimean-Congo hemorrhagic fever virus (CCHFV) is the most widely distributed tick-borne virus of human medical importance, with outbreaks occurring in the Middle East, Asia, Africa, and parts of Western Europe. Our team developed and tested
Dr. Joseph Golden, Collin Fitzpatrick, Dr John Suschak, Tamara Clements, Dr. Keersten Ricks, Mariano Sanchez-Lockhart, Dr Aura Garrison   +6 more
doaj   +1 more source

Crimean-Congo Hemorrhagic Fever: Tick-Host-Virus Interactions

Frontiers in Cellular and Infection Microbiology, 2017
Crimean-Congo hemorrhagic fever virus (CCHFV) is transmitted to humans by bite of infected ticks or by direct contact with blood or tissues of viremic patients or animals. It causes to humans a severe disease with fatality up to 30%.
Anna Papa, Katerina Tsergouli, Katerina Tsioka, Ali Mirazimi, Ali Mirazimi, Ali Mirazimi   +5 more
doaj   +1 more source

Fine Epitope Mapping of the Central Immunodominant Region of Nucleoprotein from Crimean-Congo Hemorrhagic Fever Virus (CCHFV)

PLoS ONE, 2014
Crimean-Congo hemorrhagic fever (CCHF), a severe viral disease known to have occurred in over 30 countries and distinct regions, is caused by the tick-borne CCHF virus (CCHFV). Nucleocapsid protein (NP), which is encoded by the S gene, is the primary antigen detectable in infected cells.
Dongliang Liu, Yang Li, Jing Zhao, Fei Deng, Xiaomei Duan, Chun Kou, Ting Wu, Yijie Li, Yongxing Wang, Ji Ma, Jianhua Yang, Zhihong Hu, Fuchun Zhang, Yujiang Zhang, Surong Sun   +14 more
openaire   +4 more sources

Furin effect on CCHFV-WT and-ASKA growth.

, 2015
FD11 and FD11-Fur cells were infected with CCHFV-WT or CCHFV-ASKA (MOI = 0.1). Cell supernatants were collected daily, and RNA S-segment copy numbers and infectious virus titers were measured by qRT-PCR and TCID50 determination, respectively.
Marko Zivcec (191739), Christina F. Spiropoulou (139312), César G. Albariño (139297), Ayan K. Chakrabarti (139299), Stuart T. Nichol (130422), Éric Bergeron (5663428)   +5 more
core   +1 more source

Establishment of two serological methods for detecting IgG and neutralizing antibodies against Crimean-Congo hemorrhagic fever virus glycoprotein

Frontiers in Cellular and Infection Microbiology
IntroductionThe Crimean-Congo hemorrhagic fever virus (CCHFV), the most geographically widespread tick-borne virus, is endemic in Africa, Eastern Europe and Asia, with infection resulting in mortality in up to 30% of cases.
Qi Wang, Qi Wang, Shen Wang, Zhikang Shi, Zhengrong Li, Zhengrong Li, Yongkun Zhao, Na Feng, Tiecheng Wang, Feihu Yan, Xianzhu Xia, Xianzhu Xia   +11 more
doaj   +1 more source

Screening of an FDA-approved drug library for the identification of entry inhibitors of Crimean-Congo haemorrhagic fever virus

reservedLe infezioni da virus delle febbri emorragiche rappresentano una minaccia per la salute pubblica perché sono causate da virus altamente patogeni per i quali non esistono farmaci approvati.
BOBBO, MARGHERITA
core  

Liver and spleen pathology and CCHFV distribution visualized by immunohistochemistry in mice euthanized at 5 dpi.

, 2019
Mice displayed similarly severe pathology with abundant CCHFV immunostaining. Livers had widespread, random, and confluent hepatocellular necrosis (see insets) with minimal inflammation.
Gary P. Kobinger (8067335), Stuart T. Nichol (8067341), Anita K. McElroy (8067326), Jessica R. Harmon (5540843), Jessica R. Spengler (8067344), JoAnn D. Coleman-McCray (8067329), Jana M. Ritter (8067323), Sherif R. Zaki (8067338), Éric Bergeron (5663428), Florine E. M. Scholte (8067332), Stephen R. Welch (8067320), Christina F. Spiropoulou (8067347)   +11 more
core   +1 more source

Antibodies Targeting the CCHFV Nucleocapsid Protein Require TRIM21 for Protection

Abstract Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is a negative-sense RNA virus spread by Hyalomma genus ticks across Europe, Asia, and Africa. CCHF disease begins as a non-specific febrile illness which may progress into a severe hemorrhagic disease and there are currently no widely approved or highly efficacious interventions available ...
David Hawman, Shanna Leventhal, Kimberly Meade-White, Carl Shaia, Justin Murray, Evan Mihalakakos, Troy Hinkley, Jesse Erasmus, Heinz Feldmann   +8 more
openaire   +1 more source

Environmental driven changes in tick life history can explain the variation in CCHFV prevalence in the Iberian Peninsula

Crimean-Congo haemorrhagic fever virus (CCHFV) is an emerging tick-borne zoonotic disease with a wide geographical distribution and high case mortality in humans.
Ruiz-Fons, Francisco, White, Andy; id_orcid, O'Neill, Xander, O’Neill, Xander, Gortázar, Christian, White, Andy   +5 more
core   +1 more source

Neutralizing monoclonal antibodies against the Gc fusion loop region of Crimean-Congo hemorrhagic fever virus.

PLoS Pathogens
Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly pathogenic tick-borne virus, prevalent in more than 30 countries worldwide. Human infection by this virus leads to severe illness, with an average case fatality of 40%.
Liushuai Li, Tingting Chong, Lu Peng, Yajie Liu, Guibo Rao, Yan Fu, Yanni Shu, Jiamei Shen, Qinghong Xiao, Jia Liu, Jiang Li, Fei Deng, Bing Yan, Zhihong Hu, Sheng Cao, Manli Wang   +15 more
doaj   +1 more source