Results 111 to 120 of about 4,301 (202)

Seromolecular survey and risk factor analysis of Crimean-Congo haemorrhagic fever orthonairovirus in occupationally exposed herdsmen and unexposed febrile patients in Kwara State, Nigeria.

PLoS ONE
Crimean-Congo haemorrhagic fever virus (CCHFV) is a globally significant tick-borne zoonotic pathogen that causes fatal haemorrhagic disease in humans. Despite constituting an ongoing public health threat, limited research exists on the presence of CCHFV
Oluwafemi Babatunde Daodu, Joseph Ojonugwa Shaibu, Rosemary Ajuma Audu, Daniel Oladimeji Oluwayelu   +3 more
doaj   +1 more source

Vesicular Stomatitis Virus-Based Vaccine Protects Mice against Crimean-Congo Hemorrhagic Fever

Scientific Reports, 2019
Crimean-Congo hemorrhagic fever virus (CCHFV), a tick-borne bunyavirus, can cause a life-threatening hemorrhagic syndrome in humans but not in its animal host.
Sergio E. Rodriguez, Robert W. Cross, Karla A. Fenton, Dennis A. Bente, Chad E. Mire, Thomas W. Geisbert   +5 more
doaj   +1 more source

The cap-snatching SFTSV endonuclease domain is an antiviral target [PDF]

, 2020
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%-30% case mortality rates and is related to the Heartland virus (HRTV) identified in the United States.
Amarasinghe, Gaya K, Bowman, Gregory R, Choi, Younho, Frederick, Thomas E, Gross, Michael L, Jung, Jae U, Leung, Daisy W, Shin, Woo-Jin, Wang, Wenjie, Yoo, Ji-Seung, Zhang, Bojie, Zimmerman, Maxwell I   +11 more
core   +1 more source

The CD8+T cells response is sufficient for protection with a CCHFV M-segment based DNA vaccine and GP38 enhances vaccine immunogenicity

International Journal of Infectious Diseases
Introduction: Crimean-Congo hemorrhagic fever virus (CCHFV) is the most widely distributed tick-borne virus of human medical importance, with outbreaks occurring in the Middle East, Asia, Africa, and parts of Western Europe. Our team developed and tested
Dr. Joseph Golden, Collin Fitzpatrick, Dr John Suschak, Tamara Clements, Dr. Keersten Ricks, Mariano Sanchez-Lockhart, Dr Aura Garrison   +6 more
doaj   +1 more source

Antibodies Targeting the CCHFV Nucleocapsid Protein Require TRIM21 for Protection

Abstract Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is a negative-sense RNA virus spread by Hyalomma genus ticks across Europe, Asia, and Africa. CCHF disease begins as a non-specific febrile illness which may progress into a severe hemorrhagic disease and there are currently no widely approved or highly efficacious interventions available ...
David Hawman, Shanna Leventhal, Kimberly Meade-White, Carl Shaia, Justin Murray, Evan Mihalakakos, Troy Hinkley, Jesse Erasmus, Heinz Feldmann   +8 more
openaire   +1 more source

Combination of RT-PCR and proteomics for the identification of Crimean-Congo hemorrhagic fever virus in ticks

Heliyon, 2017
Crimean-Congo hemorrhagic fever (CCHF) is an emerging tick-borne zoonotic disease caused by the CCHF virus (CCHFV). In this study, an experimental approach combining RT-PCR and proteomics was used for the identification and characterization of CCHFV in ...
Isabel G. Fernández de Mera, Ilias Chaligiannis, Angélica Hernández-Jarguín, Margarita Villar, Lourdes Mateos-Hernández, Anna Papa, Smaragda Sotiraki, Francisco Ruiz-Fons, Alejandro Cabezas-Cruz, Christian Gortázar, José de la Fuente   +10 more
doaj   +1 more source

Crimean-Congo Hemorrhagic Fever: Tick-Host-Virus Interactions

Frontiers in Cellular and Infection Microbiology, 2017
Crimean-Congo hemorrhagic fever virus (CCHFV) is transmitted to humans by bite of infected ticks or by direct contact with blood or tissues of viremic patients or animals. It causes to humans a severe disease with fatality up to 30%.
Anna Papa, Katerina Tsergouli, Katerina Tsioka, Ali Mirazimi, Ali Mirazimi, Ali Mirazimi   +5 more
doaj   +1 more source

Characterization of a Novel STAT 2 Knock Out Hamster Model of Crimean Congo Hemorrhagic Fever Virus Pathogenesis [PDF]

, 2020
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen causing a febrile illness in humans, which can progress to hemorrhagic manifestations, multi-organ failure, and death.
Booth, Stephanie, Feldmann, Heinz, Frost, Kathy, Gowen, Brian B., Miao, Jinxin, Poliquin, Guillaume, Ranadheera, Charlene, Rosenke, Kyle, Safronetz, David, Saturday, Greg, Tierney, Kevin, Valcourt, Emelissa J., Wang, Zhongde, Warner, Bryce M., Westover, Jonna B.   +14 more
core   +1 more source

Establishment of two serological methods for detecting IgG and neutralizing antibodies against Crimean-Congo hemorrhagic fever virus glycoprotein

Frontiers in Cellular and Infection Microbiology
IntroductionThe Crimean-Congo hemorrhagic fever virus (CCHFV), the most geographically widespread tick-borne virus, is endemic in Africa, Eastern Europe and Asia, with infection resulting in mortality in up to 30% of cases.
Qi Wang, Qi Wang, Shen Wang, Zhikang Shi, Zhengrong Li, Zhengrong Li, Yongkun Zhao, Na Feng, Tiecheng Wang, Feihu Yan, Xianzhu Xia, Xianzhu Xia   +11 more
doaj   +1 more source

Antibodies targeting the Crimean-Congo Hemorrhagic Fever Virus nucleoprotein protect via TRIM21

Nature Communications
Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is a negative-sense RNA virus spread by Hyalomma genus ticks across Europe, Asia, and Africa. CCHF disease begins as a non-specific febrile illness which may progress into a severe hemorrhagic disease with no
Shanna S. Leventhal, Thomas Bisom, Dean Clift, Deepashri Rao, Kimberly Meade-White, Carl Shaia, Justin Murray, Evan A. Mihalakakos, Troy Hinkley, Steven J. Reynolds, Sonja M. Best, Jesse H. Erasmus, Leo C. James, Heinz Feldmann, David W. Hawman   +14 more
doaj   +1 more source