CCL11 promotes angiogenic activity by activating the PI3K/Akt pathway in HUVECs
Journal of Receptor and Signal Transduction Research, 2017 CCR3, the receptor for CCL11, is expressed on the surface of immune cells and even on non-immune cells. CCL11-CCR3 interactions can promote cell migration and proliferation. In this study, we investigated the effect of CCL11 on angiogenesis in HUVECs and also examined the molecular mechanisms of this process.
Jun Young Park +2 more
exaly +5 more sources
Expression of Ccl11 associates with immune response modulation and protection against neuroinflammation in rats. [PDF]
PLoS ONE, 2012 Multiple sclerosis (MS) is a polygenic disease characterized by inflammation and demyelination in the central nervous system (CNS), which can be modeled in experimental autoimmune encephalomyelitis (EAE).
Milena Z Adzemovic +11 more
doaj +5 more sources
Eotaxin/CCL11 in idiopathic retroperitoneal fibrosis [PDF]
Nephrology Dialysis Transplantation, 2012 Idiopathic retroperitoneal fibrosis (IRF) is a rare fibro-inflammatory disorder characterized by a periaortic tissue which often encases the ureters causing acute renal failure. IRF histology shows fibrosis and a chronic inflammatory infiltrate with frequent tissue eosinophilia.
Mangieri, D +12 more
core +7 more sources
SNPs in inflammatory genes CCL11, CCL4 and MEFV in a fibromyalgia family study.
PLoS ONE, 2018 BackgroundFibromyalgia (FM) is a chronic pain syndrome with a high incidence in females that may involve activation of the immune system. We performed exome sequencing on chemokine genes in a region of chromosome 17 identified in a genome-wide family ...
Zhifang Zhang +10 more
doaj +4 more sources
Effect of CCL11 on In Vitro Myogenesis and Its Clinical Relevance for Sarcopenia in Older Adults [PDF]
Endocrinology and Metabolism, 2021 Background The C-C motif chemokine ligand 11 (CCL11) has been receiving attention as a potential pro-aging factor. Accordingly, it may be involved in muscle metabolism and sarcopenia, a key component of aging phenotypes.
Da Ae Kim +9 more
doaj +2 more sources
Prognostic Value of CXCL13, CCL11, and CCL20 Chemokines in Multiple Sclerosis
BiomedicinesObjective: The course of relapsing–remitting multiple sclerosis (RRMS) is highly variable and there is a lack of effective prognostic biomarkers. This study aimed to assess the potential prognostic value of the chemokines B lymphocyte chemoattractant ...
Işıl Peker +9 more
doaj +4 more sources
CCL11 Differentially Affects Post-Stroke Brain Injury and Neuroregeneration in Mice Depending on Age [PDF]
Cells, 2019 CCL11 has recently been shown to differentially affect cell survival under various pathological conditions including stroke. Indeed, CCL11 promotes neuroregeneration in neonatal stroke mice.
Simone Lieschke +10 more
doaj +2 more sources
IL-9 induces CCL11 expression via STAT3 signalling in human airway smooth muscle cells. [PDF]
PLoS ONE, 2010 Previous findings support the concept that IL-9 may play a significant role in mediating both pro-inflammatory and changes in airway responsiveness that characterizes the atopic asthmatic state. We previously demonstrated that human airway smooth muscle (
Akira Yamasaki +5 more
doaj +2 more sources
CD14+CD33+ myeloid cell-CCL11-eosinophil signature in ulcerative colitis [PDF]
Journal of Leukocyte Biology, 2013 ABSTRACTThis study tested the hypothesis that eotaxins (CCL11, CCL24, and CCL26) and IL-5 contribute to eosinophil recruitment to the intestine in UC and that intestinal macrophages are important producers of CCL11 in this disease. Peripheral blood and rectal biopsy samples were obtained from patients with active (n=18) and quiescent UC (n=9), and ...
Maria, Lampinen +4 more
openaire +3 more sources
Role of CCL11 in Eosinophilic Lung Disease during Respiratory Syncytial Virus Infection [PDF]
Journal of Virology, 2005 ABSTRACTRespiratory syncytial virus (RSV) is a major viral pathogen of infants and the elderly. Significant morbidity is caused by an overexuberant mixed lung cell infiltrate, which is thought to be driven by chemokines. One of the main chemotactic mediators responsible for the movement of eosinophils is CCL11 (eotaxin).
Matthews, Stephen P. +4 more
openaire +4 more sources