Results 201 to 210 of about 86,321 (247)

Glucocorticoid-mediated suppression of the CCL2-CCR2 axis drives monocyte dysfunction in severe pneumonia among immunocompromised hosts. [PDF]

Respir Res
Kuang Z, Luo Y, Chen Y, Yang Y, Chen C, Xu F, Chen Y, Zhou Y, Shen Y, Yuan L, Su H, Tong C, Song Z.   +12 more
europepmc   +1 more source

The Role of Inflammation in Infant Colic—A Systematic Review and Meta‐Analysis

Acta Paediatrica, EarlyView.
ABSTRACT Aim Despite being a self‐limiting condition, infant colic is associated with negative consequences for caregivers and infants. Gut inflammation is hypothesised as a contributing factor. We collected and meta‐analysed the most recent evidence on the association between infant colic and gut inflammation.
Dan Boëtius Andersen, Julius Fog, Marie V. Vestergaard, Ida Scheel Rasmussen, Philip Wilson, Gritt Overbeck, Louise Bidstrup Jørgensen, Jakob Kragstrup, Betina Hebbelstrup Jensen   +8 more
wiley   +1 more source

Vessel‐associated microglia are differentially activated and distributed in relation to systemic infection and Alzheimer's disease

Brain Pathology, EarlyView.
This post‐mortem study revealed an increased density of vessel‐associated microglia (VAM) in the temporal lobe in systemic infection and Alzheimer's disease. VAM density was related to brain cytokine levels and markers of cerebrovascular dysfunction and BBB leakage indicating that activated VAM contributes to neurovascular injury in Alzheimer's disease.
Oliver Milner, Robert A. Fisher, Daniel J. Asby, Stephen Cross, Delphine Boche, J. Scott Miners   +5 more
wiley   +1 more source

CCR2 improves tumor directed CAR-T cell trafficking in ovarian cancer. [PDF]

Front Pharmacol
Kumar R, Veillard IE, Xu M, Al-Alem L, Rueda BR, Yeku OO.   +5 more
europepmc   +1 more source

Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease

Brain Pathology, EarlyView.
Neuritic plaques increase in the intermediate stage of Alzheimer's neuropathological change. The intermediate stage of Alzheimer's disease was investigated by transcriptomics and immunohistochemistry. This revealed that inflammasome sensors NLRP1, NLRP3, and AIM2 oligomerize with ASC speck to form the inflammasome complex and initiate the downstream ...
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

Single cell RNA sequencing analysis and molecular biology experiments identify NAFLD-related fibroblasts and highlights seven hub genes in NAFLD. [PDF]

PLoS One
Zhang X, Cheng Y, Yu R, Hu X, Huang Y.
europepmc   +1 more source

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Cancer Manipulates Adjacent Adipose Tissue to Exploit Fatty Acids via HIF-1α/CCL2/PPARα Axis: A Metabolic Circuit to Support Tumor Progression. [PDF]

Adv Sci (Weinh)
Yun JE, Seo J, Koh J, Im SA, Hong KY, Son Y, Jeong DW, Fukuda J, Park JW, Chun YS.   +9 more
europepmc   +1 more source

Tenascin C⁺ myofibroblasts exacerbate vascular neointimal hyperplasia by propagation of nerve-macrophage interactions in mice. [PDF]

Nat Commun
Tong X, Shi G, Fang Z, Tang S, Zhou B, Meng Q, Zhang P, Li H, Cai X, Wang Z, Zheng X, Chen W, Jiang G, Wang H, Jiang D, Li Q.   +15 more
europepmc   +1 more source

Cytokine Dynamics in Bortezomib-Induced Peripheral Neuropathy: Challenges in Translating Preclinical Findings to Humans. [PDF]

J Peripher Nerv Syst
Cebulla N, Schirmer D, Runau E, Flamm L, Terhorst C, Jähnel L, Güse J, Giordani N, Wieser A, Schoch F, Reinle ML, Gommersbach S, Papagianni A, Zhou X, Einsele H, Reinhold AK, Rittner H, Kortüm KM, Sommer C.   +18 more
europepmc   +1 more source