Results 91 to 100 of about 76,869 (253)
β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma
Advanced Science, EarlyView.β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto +20 more
wiley +1 more source
Discover OncologyObjectives C–C Motif Chemokine Ligand 5 (CCL5) is known for its role in immune regulation and has been implicated in cancer progression. However, its expression and prognostic significance in pan-cancer require comprehensive evaluation.
Wenming Zhao +4 more
doaj +1 more source
MicroRNA-155 regulates monocyte chemokine and chemokine receptor expression in Rheumatoid Arthritis [PDF]
, 2016 Objectives: To test the hypothesis that miR-155 regulates monocyte migratory potential via modulation of chemokine and chemokine receptor expression in rheumatoid arthritis (RA); and thereby is associated with disease activity.
Elmesmari, Aziza +8 more
core +1 more source
Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration
Advanced Science, EarlyView.Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman +5 more
wiley +1 more source
VIP contribution to the decidualization program: regulatory T cell recruitment [PDF]
, 2014 During early pregnancy, the human uterus undergoes profound tissue remodeling characterized by leukocyte invasion and production of proinflammatory cytokines, followed by tissue repair and tolerance maintenance induction.
Agüero, Mariana +5 more
core +1 more source
CCR5 and CCL5 in metastatic colorectal cancer
Journal for ImmunoTherapy of CancerThe CCR/L5 axis is known for its role in immune regulation in a variety of settings and has been shown to have dichotomous functions in cancer, influencing both tumor progression and immune responses. Battaglin et al investigated its role using genomic and transcriptomic data from several datasets of patients with advanced colorectal cancer (CRC ...
Benjamin L Schlechter, Justin Stebbing
openaire +3 more sources
Advanced Science, EarlyView.To address the limitations of protein‐based ICIs in applications, this study constructed an engineered bacterium, HRB, capable of expressing aCD47 in hypoxic TME. Through the Schiff base reaction, responsive liposomes (LC) loaded with the STING agonist cGAMP were connected to the surface of bacteria to form HRB@LC.
Peng‐Shuo Dong +9 more
wiley +1 more source
Porphyromonas gingivalis lipopolysaccharide alters atherosclerotic-related gene expression in oxidized low-density-lipoprotein-induced macrophages and foam cells [PDF]
, 2011 The molecular mechanism between atherosclerosis formation and periodontal pathogens is not clear although positive correlation between periodontal infections and cardiovascular diseases has been reported.
de Winther +23 more
core +2 more sources
Filamentous chemokine CCL5 structure and the functional aspects
Scientific ReportsHuman inflammation-related CC chemokine ligand 5 (hCCL5) has significant self-assembly property under physiological conditions. The mechanism and function of hCCL5 oligomerization remain unclear. Different intermolecular interactions, such as E66-K25 or E66-R44/K45, have been reported to mediate hCCL5 oligomerization.
Yi-Ting Yuan +13 more
openaire +3 more sources
Advanced Science, EarlyView.Sensory nerves help bones heal. This study shows that the neuropeptide CGRP, released from sensory nerves, slows down macrophage energy production, preventing excessive bone breakdown. By revealing this nerve–immune–metabolism connection, the work provides new insight into how the body balances bone repair and opens doors to targeted treatments ...
Jiaying Liu +10 more
wiley +1 more source