Results 101 to 110 of about 59,717 (249)

CCL5 is essential for axonogenesis and neuronal restoration after brain injury

Journal of Biomedical Science
Background Traumatic brain injury (TBI) causes axon tearing and synapse degradation, resulting in multiple neurological dysfunctions and exacerbation of early neurodegeneration; the repair of axonal and synaptic structures is critical for restoring ...
Man-Hau Ho, Yih-Jeng Tsai, Chia-Yen Chen, Anastasia Yang, Thierry Burnouf, Yun Wang, Yung-Hsiao Chiang, Barry J. Hoffer, Szu-Yi Chou   +8 more
doaj   +1 more source

Layer‐Specific Dermal and Subcutaneous Delivery via Modular LNP–Hydrogel‐Integrated Threaded Microneedles

Advanced Science, EarlyView.
Guided by spatial transcriptomics and clinical validation, a threaded microneedle platform enables precise layer‐specific delivery across the dermis and subcutaneous tissue. By addressing distinct pathogenic remodeling in different skin layers, this strategy coordinates compartment‐specific intervention, restores tissue architecture, and offers a ...
Fangzhou Xie, Yixiang Zhang, Shifeng Ling, Yuxuan Huang, Yingying Wei, Rao Fu, Jiahao He, Baikun Liu, Lucia Zhou, Kaifeng Huo, Yida Wang, Qingfeng Li, Yawei Du, Wenguo Cui, Yun Xie   +14 more
wiley   +1 more source

Functional characterization of the tagged-CCL5 chemokines.

, 2014
A. Representative TEVC recordings performed on Xenopus oocytes expressing Kir3.1* or co-expressing CCR5 and Kir3.1* and subjected to applications of the indicated CCL5 chemokines at 1 µM. B.
Lina Šiaučiūnaiteė-Gaubard (517703), Franck Fieschi (296308), Rabia Sadir (35737), Lydia Caro (517705), Michel Vivaudou (141672), Isabelle Petit-Hartlein (517704), Antoine Picciocchi (76735), Christophe Moreau (517706), Corinne Vivès (517707), Jean Revilloud (226552)   +9 more
core   +1 more source

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex‐Differential Proteins and Candidate Therapeutic Targets

Advanced Science, EarlyView.
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Xinjie Lin, Yangchang Zhang, Yang Pu, Duanke Liu, Tao Lei, Kai Ma, Qiyu He, Zheng Dou, Yuze Liu, Dengyuan Liu, Yinge He, Yanshang Wang, Xiaojiao Zheng, Yanbing Ma, Jianrong Zhou, Weiding Zhai, Binbin Su, Li Chen, Shoujun Li   +18 more
wiley   +1 more source

Role of CCL5 (RANTES) in viral lung disease

, 2006
CCL5/RANTES is a key proinflammatory chemokine produced by virus-infected epithelial cells and present in respiratory secretions of asthmatics. To examine the role of CCL5 in viral lung disease, we measured its production during primary respiratory ...
Gerhard Walzl, Timothy N. Wells, Jonathan S. Dodd, Tracy Hussell, Peter J. M. Openshaw, Pennycook, Alasdair M J, Alasdair M. J. Pennycook, Wells, Timothy N., Fiona J. Culley, Openshaw, Peter J M, Tregoning, John S., Culley, Fiona J., Dodd, Jonathan S., Walzl, Gerhard, Hussell, Tracy; id_orcid, John S. Tregoning   +15 more
core   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Engineered Exosomes Carrying miR-588 for Treatment of Triple Negative Breast Cancer Through Remodeling the Immunosuppressive Microenvironment

International Journal of Nanomedicine
Zhengjia Zhang,1,* Xinyi Luo,1,* Xiaoxia Xue,1 Mingshi Pang,1 Xiangpeng Wang,1 Liuchunyang Yu,1 Jinxiu Qian,1 Xiaoyu Li,1 Meng Tian,1 Aiping Lu,2 Cheng Lu,3 Yuanyan Liu1 1School of Materia Medica, Beijing University of Chinese Medicine, Beijing ...
Zhang Z, Luo X, Xue X, Pang M, Wang X, Yu L, Qian J, Li X, Tian M, Lu A, Lu C, Liu Y   +11 more
doaj  

Poly(I:C)‐Activated Nasal Fibroblasts Promote Eosinophil Recruitment in CRSwNP

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by persistent mucosal inflammation and eosinophilic infiltration. Although epithelial and immune cells have been widely studied, the role of nasal fibroblasts in innate immune activation and eosinophil recruitment remains unclear.
Chaewon Shin, An‐Gi Kim, Byeong Min Yu, Woo‐Keun Kwon, Min‐Ho Hwang, Joo‐Hoo Park   +5 more
wiley   +1 more source

CCL5 and CCR5 interaction increased migration of human osteosarcoma cells.

, 2012
(A&B) MG63 or U20S cells were incubated with various concentrations of CCL5, and in vitro migration and invasion activity measured with the Transwell after 24 h. (C) MG63 cells were incubated with CCL5 (3 ng/ml) for 24 h, and the mRNA expression of CCR1,
Yung-Shuen Shen (173028), Shih-Wei Wang (172988), Hsing-Hsien Wu (172993), Wen-Chieh Ou (173015), Chih-Hsin Tang (104506), Po-Chuan Wang (173005), Shih-Chia Liu (172999), Wen-Yi Chou (173022)   +7 more
core   +1 more source

CCL5 paradoxically regulates glomerular injury by skewing macrophage polarization

JCI Insight
Glomerular inflammation and podocyte loss are the hallmarks of chronic kidney disease (CKD) progression. Understanding how podocytes and their microenvironment regulate inflammation is critical for developing effective therapies.
Ika N. Kadariswantiningsih, Issei Okunaga, Kaho Yamasaki, Maulana A. Empitu, Hiroyuki Yamada, Shin-ichi Makino, Akitsu Hotta, Hideo Yagita, Masashi Aizawa, Ryo Koyama-Nasu, Motoko Y. Kimura, Narihito Tatsumoto, Katsuhiko Asanuma   +12 more
doaj   +1 more source