Results 91 to 100 of about 59,717 (249)

A Metal‐Polyphenol Self‐Assembled Coated 3D Sponge With Mild Photothermal Antibacterial, Exudate‐Controlling, and Immunomodulatory Functions for Hemostasis and Chronic Wound Healing

Advanced Science, EarlyView.
A thrombin‐functionalized copper‐polydopamine nanofiber sponge integrates rapid hemostasis, mild photothermal antibacterial therapy, stimulus‐responsive Cu2+ release, chemodynamic oxidative stress, and macrophage immunomodulation. This multifunctional dressing suppresses infection, regulates inflammation, promotes angiogenesis and re‐epithelialization,
Ziwei Zhang, Feng Qin, Xiaomeng Zhang, Xueqin Shuang, Jiahua Zhou, Ming Cheng, Baicheng Lu, Mingyue Song, Yuntian Bai, Dianying Zhang, Ming Li, Yanhua Wang   +11 more
wiley   +1 more source

Interleukin‐1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis

Advanced Science, EarlyView.
During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Hala Mazloum, Shenja Buchholz, Hanna Schifter, Sabine Ameling, Leif Steil, Ben Lewin Becker, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Lukas Zierke, Frank Ulrich Weiss, Juliane Glaubitz, Matthias Sendler   +13 more
wiley   +1 more source

Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications

Frontiers in Oncology, 2019
Triple-negative breast cancer (TNBC) accounts for ~15–20% of breast cancer (BC) and has a higher rate of early relapse and mortality compared to other subtypes. The Chemokine (C-C motif) ligand 5 (CCL5) and its signaling pathway have been linked to TNBC.
Jingxuan Shan, Jingxuan Shan, Jingxuan Shan, Aziz Chouchane, Younes Mokrab, Mohamad Saad, Salha Boujassoum, Rosalyn W. Sayaman, Rosalyn W. Sayaman, Rosalyn W. Sayaman, Elad Ziv, Elad Ziv, Noureddine Bouaouina, Noureddine Bouaouina, Yasmine Remadi, Sallouha Gabbouj, Jessica Roelands, Xiaojing Ma, Davide Bedognetti, Lotfi Chouchane, Lotfi Chouchane, Lotfi Chouchane   +21 more
doaj   +1 more source

Knockdown of CCL5 inhibited the migratory ability in osteosarcoma cells.

, 2012
(A) The in vitro migration activity of MG63/control-shRNA and MG63/CCL5-shRNA cells was measured with the Transwell. (B–D) The mRNA levels of CCL5, αv and β3 integrin in MG63/control-shRNA and MG63/CCL5-shRNA cells was examined by qPCR.
Yung-Shuen Shen (173028), Shih-Wei Wang (172988), Hsing-Hsien Wu (172993), Wen-Chieh Ou (173015), Chih-Hsin Tang (104506), Po-Chuan Wang (173005), Shih-Chia Liu (172999), Wen-Yi Chou (173022)   +7 more
core   +1 more source

FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape

Advanced Science, EarlyView.
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu, Xingwei Xie, Xiaohuan Wu, Suidong Ouyang, Yang Zhou, Kang Wen, Yutong Zhong, Yuyang Chen, Handuo Wang, Yuan Gao, Ling Jiang, Hui Li, Wenli Zhao, Abai Xu, Enguang Bi   +14 more
wiley   +1 more source

Immunocytochemistry of CCL5 induced by HIV-1 Tat in astrocytes.

, 2013
(A–I) SVGA astrocytes were grown on a cover slip before transfecting with HIV-1 Tat plasmid. Untransfected control (A–C) and mock-transfected cells (D–F) were used to compare the up-regulation of CCL5 in cells transfected with HIV-1 Tat (G–I).
Anil Kumar (105720), Ankit Shah (294064), Richard J. Noel (482717), Anantha R. Nookala (482716)   +3 more
core   +1 more source

Single-Cell RNA Sequencing Reveals Peripheral Immune Cell Senescence and Inflammatory Phenotypes in Patients with Premature Ovarian Failure

Journal of Inflammation Research
Jianan Liu,1 Li Wang,2 Weijun Zhong,1 Jing Cai,3 Yan Sun,3 SongJun Li,2 Jiayi Li,4 Yanhui Liu,2 Fu Xiong1,5,6 1Department of Medical Genetics/Experimental Education/Administration Center, School of Basic Medical Sciences, Southern Medical University ...
Liu J, Wang L, Zhong W, Cai J, Sun Y, Li S, Li J, Liu Y, Xiong F   +8 more
doaj  

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

CCL5 rs2107538 Polymorphism Increased the Risk of Tuberculosis in a Sample of Iranian Population

Prague Medical Report, 2016
Cysteine-cysteine chemokine ligand 5 (CCL5) with immunoregulatory and inflammatory activities has an important role in granuloma formations that activates and stimulates T-cells and macrophages.
Hamid Reza Kouhpayeh, Mohsen Taheri, Mana Baziboroon, Mohammad Naderi, Gholamreza Bahari, Mohammad Hashemi   +5 more
doaj   +1 more source

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source