Results 121 to 130 of about 59,717 (249)

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

BMEMat, EarlyView.
Nanomedicine‐Driven Strategies for Suppressing Postoperative Tumor Recurrence. This schematic illustrates three pivotal nanomedical strategies that synergistically counteract recurrence by targeting residual disease and the immunosuppressive tumor microenvironment within the surgical cavity.
Lisong Pang, Zhuomin Wang, Zhenhua Jin, Ahmed H. Ghonaim, Hengcheng Zhang, Xinyu You, Jinzhuo Ning, Jiaqing Cao, Yang Liu   +8 more
wiley   +1 more source

New insight into a simple high-yielding method for the production of fully folded and functional recombinant human CCL5

Scientific Reports
Chemokines are proteins important for a range of biological processes from cell-directed migration (chemotaxis) to cell activation and differentiation.
Afzaal Tufail, Saeed Akkad, Amanda R. Noble, Martin A. Fascione, Nathalie Signoret   +4 more
doaj   +1 more source

Heparan sulfate-dependent phase separation of CCL5 and its chemotactic activity

eLife
Secreted chemokines form concentration gradients in target tissues to control migratory directions and patterns of immune cells in response to inflammatory stimulation; however, how the gradients are formed is much debated.
Xiaolin Yu, Guangfei Duan, Pengfei Pei, Long Chen, Renji Gu, Wenrui Hu, Hongli Zhang, Yan-Dong Wang, Lili Gong, Lihong Liu, Ting-Ting Chu, Jin-Ping Li, Shi-Zhong Luo   +12 more
doaj   +1 more source

Integrating Recycling and Emission Reduction: A Business Strategy Analysis With Multi‐Objective Mixed‐Integer Linear Programming Framework for Optimising Sustainable Closed‐Loop Supply Chain Network Design

Business Strategy and the Environment, EarlyView.
ABSTRACT This research develops an integrated mixed‐integer linear programming (MILP) model for closed‐loop supply chain network design that optimises competing economic and environmental objectives including profit maximisation, supplier quality improvement and CO2 emission reduction.
Reza Eslamipoor
wiley   +1 more source

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries, Alastair M. Kilpatrick, Kathleen M. Scullion, Rhona Aird, Lorraine Bruce, Maria Elena Candela, Tak Yung Man, Stuart J. Forbes, James W. Dear   +8 more
wiley   +1 more source

The CCL5-CCR5 Axis in Breast Cancer

, 2015
Cancer is one of the leading underlying causes of death worldwide. Despite decades of research, cancer is predicted to be the leading cause of death by the year 2020. Anti angiogenic therapies that target the key signalling molecule, vascular endothelial
Sax, Michael John
core   +1 more source

Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice

, 2010
Activation of hepatic stellate cells in response to chronic inflammation represents a crucial step in the development of liver fibrosis. However, the molecules involved in the interaction between immune cells and stellate cells remain obscure. Herein, we
Gaßler, Nikolaus, Hacer Sahin, Anna Rueland, Mirko Moreno Zaldivar, Moreno Zaldivar, Mirko, Marie-Luise Berres, Weiskirchen, Ralf, Weber, Christian, Christian Trautwein, Streetz, Konrad L., Zaldivar, Mirko Moreno, Petra Schmitz, Nikolaus Gassler, Trautwein, Christian, Thomas Berg, Sahin, Hacer, Koenen, Rory R., Heinrichs, Daniel, Koenen, Rory R.; id_orcid, Berres, Marie-Luise, Proudfoot, Amanda E., Streetz, Konrad Ludwig, Daniel Heinrichs, Wasmuth, Hermann E., Proudfoot, Amanda, Ralf Weiskirchen, Koenen, Robert Ryan, Rory R. Koenen, Hermann E. Wasmuth, Schmitz, Petra, Berg, Thomas, Rueland, Anna, Konrad L. Streetz, Amanda Proudfoot, Christian Weber   +34 more
core   +1 more source

Astrocytic CCL5 orchestrates CCR5-positive neuronal necroptosis in subarachnoid hemorrhage

Background Early brain injury (EBI) following subarachnoid hemorrhage (SAH) is a major determinant of poor outcomes, yet its molecular mechanisms remain incompletely understood.
Lin, Wan-Lan, Sun, Wei-Wei, Si-Qi Xue, Jun-Xin Zhao, Li, Si-Jun, De-Zhi Kang, Kang, De-Zhi, Wan-Lan Lin, Wang, Ying, Zu-Cheng Ye, Yu-He Jiang, Ping Chen, Meng-Yu Shi, Shi, Meng-Yu, Lin, Qing-Song, Wei-Wei Sun, Qing-Song Lin, Chen, Ping, Ying Wang, Xue, Si-Qi, Zhao, Jun-Xin, Jiang, Yu-He, Si-Jun Li, Ye, Zu-Cheng   +23 more
core   +1 more source

Influence of the chemokine CCL5 on arterial thrombosis and neointima formation following experimental arterial injury

, 2016
Die Atherosklerose ist eine progressiv fortschreitende entzündliche Erkrankung der Gefäße. Dem Chemokin CCL5 kommt in der Modulation sowie der Progression eine entscheidende Rolle zu.
Meier, Julia
core   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source