Results 151 to 160 of about 59,717 (249)
Allergy, EarlyView.ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan +5 more
wiley +1 more source
CCL5 exposure promotes acute and transient megakaryopoiesis and hematopoietic progenitor expansion. [PDF]
Stem Cell ReportsBarrachina MN +15 more
europepmc +1 more source
Andrology, EarlyView.ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam +7 more
wiley +1 more source
Acta Paediatrica, EarlyView.ABSTRACT Aim This study aimed to explore clinical and laboratory markers of omalizumab response in paediatric and adult chronic spontaneous urticaria (CSU) patients. Methods The study included 32 children and 67 adults with CSU receiving omalizumab, and 29 paediatric and 30 adult healthy controls; associations with treatment response were evaluated ...
Güler Yıldırım Nalbant +14 more
wiley +1 more source
[[alternative]]The Relationship between the Circulating Plasma CCL5 andExercise Performance
[[abstract]]本研究旨在探讨CCL5与女性大学生运动表现之间的关系。本研究招募了12名训练有素和12名未训练的女性大学生，测量了她们的身体成分、运动表现（上肢力量、核心力量、柔韧性、灵活性、平衡性和耐力）以及血液中的CCL5水平。结果显示，训练组的垂直跳、俯卧撑、仰卧起坐、快速脚步、单腿站立、高抬腿和肌肉质量显著高于未训练组。同时，训练组的CCL5水平高于未训练组。CCL5水平与肌肉质量之间存在中度正相关性。综上所述，这些发现表明，CCL5可上调骨骼肌质量，从而增强运动表现 ...
瓦哈布, Wahab, Abdillah
core
Brain Pathology, EarlyView.Integrated histological and transcriptional profiling of the glioblastoma periphery reveals clinically relevant tumor infiltration beyond MRI‐defined boundaries. MRI‐guided biopsies from contrast‐enhancing (CE), non‐contrast‐enhancing (nCE), edema (E), and radiologically normal (N) regions demonstrate that nCE areas frequently retain neoplastic and ...
Olaya de Dios +18 more
wiley +1 more source
IFI44L modulates chemoradiotherapy sensitivity and CD8<sup>+</sup> T cell infiltration in colorectal cancer. [PDF]
Front OncolZheng L, Li M, Yan R, Tan W.
europepmc +1 more source
Alamandine/MrgD pathway modulates gut–bone marrow axis in ageing
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Ageing is associated with colon epithelial barrier disruption and up‐regulation of myelopoiesis in the bone marrow (BM). Alamandine (Ala) and MrgD are novel members of the renin angiotensin system (RAS). This study tested the hypothesis that Ala restores the colon epithelial barrier integrity in ageing via modulating gut–
Kishore Chittimalli +6 more
wiley +1 more source
Monocytes recruitement : RANTES/CCL5 effect on endothelial cells
, 2018 L’inflammation vasculaire est caractérisée par le recrutement monocytaire qui englobe l’arrêt, l’adhérence puis la migration trans-endothéliale des monocytes à travers l’endothélium vasculaire.
Mamoune, Hadjer
core
Chemokine-Armed Oncolytic Viruses: Engineering Immune Cell Trafficking to Transform the Tumor Microenvironment. [PDF]
PharmaceuticsAlwithenani A.
europepmc +1 more source