Results 191 to 200 of about 59,717 (249)

Understanding the Molecular Landscape of Alopecia Areata: Key Genes, Regulatory Networks, and Therapeutic Targets. [PDF]

Health Sci Rep
AbdElneam AI, Al-Dhubaibi MS, Bahaj SS, Mohammed GF, Atef LM.   +4 more
europepmc   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

CCL5 and CD11b-fibrin interactions regulate microglia migration and morphology in hyperinflammatory experimental cerebral malaria. [PDF]

J Neuroinflammation
Domingo ND, Solomon OD, Villarreal P, Aussenac F, Vanegas D, Endrino MJ, Mendiola AS, Puebla-Clark L, Gbedande K, Cardona AE, Akassoglou K, Flick MJ, Vargas G, Stephens R.   +13 more
europepmc   +1 more source

Adipocyte‐Derived KIF13B Aggravates Obesity‐Associated Metabolic Dysfunction via LRP1/PPARγ Signaling

MedComm, Volume 7, Issue 10, October 2026.
Adipocyte‐derived KIF13B promotes LRP1 localization and nuclear LRP1–PPARγ transcriptional activity, thereby enhancing adipogenic gene expression, lipid accumulation, and obesity‐associated metabolic dysfunction. Adipocyte‐specific Kif13b deletion disrupts this LRP1/PPARγ axis, suppresses adipogenic programming, reduces adipose expansion, and protects ...
Guolin Miao, Zhaoling Li, Lianxin Zhang, Yitong Xu, Ziwei Wang, Zixun Wang, Aiden Xian, Liwen Zheng, Jingxuan Chen, Yufei Han, Chunhua Shan, Kaikai Lu, Ming Tao, Ling Zhang, Weiguang Zhang, Wei Huang, Yuhui Wang, Rui Wei, Erdan Dong, Xunde Xian   +19 more
wiley   +1 more source

The chemokine network in triple-negative breast cancer: its role in immune microenvironment regulation, and prospects for targeted therapy. [PDF]

Front Immunol
Wang W, Chen L, Guo W, Hu M, Han X, Xia X, Xu W, Ma W.   +7 more
europepmc   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Revealing the Interactions of Regulatory Factors in the Immune Microenvironment of Breast Cancer Based on Two-Way Orthogonal Partial Least Square Model and Cell Communication. [PDF]

Cancer Med
Yang Z, Du T.
europepmc   +1 more source

Targeting the DNA Damage Response in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Targeting the DNA damage response (DDR) reshapes both tumor vulnerability and antitumor immunity. DNA lesions and DDR inhibitors can promote cytosolic nucleic‐acid sensing, antigen presentation, and immune activation, but can also induce adaptive immune escape.
Yihuan Qiao, Boyu Kang, Jian Zhang, Rui Zhang, Jipeng Li   +4 more
wiley   +1 more source

Enhancing CAR-T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF-Mediated Angiogenesis. [PDF]

Adv Sci (Weinh)
Sun S, Li Q, Wang B, Wang G, Xue Y, Liang Y, Hu C, Wang Z, Gao X, Xu H, Song J, Li H, Li L, Liu X, Tang PM, Zhang Q.   +15 more
europepmc   +1 more source

Decoding the cGAS-STING-eosinophils predictive and natural therapeutic molecular signature in burn injury progression and keloid formation: insights from artificial intelligence-driven multiomics. [PDF]

Front Surg
Li J, Yang Q.
europepmc   +1 more source