Results 211 to 220 of about 50,982 (245)
The CCL5/CCR5 Axis in Cancer Progression [PDF]
Cancers, 2020 Tumor cells can “hijack” chemokine networks to support tumor progression. In this context, the C-C chemokine ligand 5/C-C chemokine receptor type 5 (CCL5/CCR5) axis is gaining increasing attention, since abnormal expression and activity of CCL5 and its receptor CCR5 have been found in hematological malignancies and solid tumors. Numerous preclinical in
Donatella Aldinucci +2 more
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Targeting CCL5 in inflammation [PDF]
Expert Opinion on Therapeutic Targets, 2013 Chemokines play important roles in inflammation and in immune responses. This article will discuss the current literature on the C-C chemokine ligand 5 (CCL5), and whether it is a therapeutic target in the context of various allergic, autoimmune or infectious diseases.Small-molecule inhibitors, chemokine and chemokine receptor-deficient mice ...
Rafael Elias Marques +2 more
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CCL5/CCR5 axis in human diseases and related treatments
Genes and Diseases, 2022 To defense harmful stimuli or maintain the immune homeostasis, the body produces and recruits a superfamily of cytokines such as interleukins, interferons, chemokines etc. Among them, chemokines act as crucial regulators in defense systems. CCL5/CCR5 combination is known for facilitating inflammatory responses, as well as inducing the adhesion and ...
Zhen Zeng, Tianxia Lan, Yuquan Wei
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CCL5 as an adjuvant for cancer immunotherapy
Expert Opinion on Biological Therapy, 2010To date cancer immunotherapy has only achieved limited clinical efficacy, thus more efficient immunotherapeutic approaches need to be explored. The CC chemokine CCL5 plays a role in chemoattraction and activation of immune cells implying its potential clinical application as an adjuvant for boosting anti-tumor immunity, although an effect on ...
Natalia, Lapteva, Xue F, Huang
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Inhibition of metastasis by inhibition of tumor-derived CCL5
Breast Cancer Research and Treatment, 2005To determine whether tumor-derived CCL5 contributes to the metastatic potential of murine mammary carcinoma, we used the 4T1 tumor which spontaneously metastasizes and constitutively produces CCL5. Mice bearing 4T1 that expressed less CCL5 had significantly fewer lung and liver metastasis.
Robert A Kurt, Kurt Robert A
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Angiogenic properties of the chemokine RANTES/CCL5
Biochemical Society Transactions, 2011Atherosclerosis is an inflammatory disease that is one of the leading causes of death in developed countries. This disease is defined by the formation of an atherosclerotic plaque, which is responsible for artery obstruction and affects the heart by causing myocardial infarction.
Suffee, Nadine +5 more
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The inflammatory chemokines CCL2 and CCL5 in breast cancer
Cancer Letters, 2008A causal role was recently attributed to inflammation in many malignant diseases, including breast cancer. The different inflammatory mediators that are involved in this disease include cells, cytokines and chemokines. Of these, many studies have addressed the involvement and roles of the inflammatory chemokines CCL2 (MCP-1) and CCL5 (RANTES) in breast
Adit Ben-Baruch
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The potential to target CCL5/CCR5 in breast cancer
Expert Opinion on Therapeutic Targets, 2014Chemokines play a crucial role in breast cancer tumorigenesis and progression. Recently, the chemokine (C-C motif) ligand 5 (CCL5), which can be secreted either by tumor cells or by mesenchymal stromal cells recruited to the tumor, has been identified as a key node in the bidirectional communication between breast cancer and normal cells.In this review,
Marco, Velasco-Velázquez +2 more
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The CCL5/CCR5 axis in ulcerative colitis
Cellular ImmunologyUlcerative colitis (UC) is a chronic nonspecific inflammatory bowel disease characterized mainly by inflammatory changes in the intestinal mucosa. While the specific etiology of UC remains unclear, it is generally believed that it is related to many factors, among which the imbalance in the expression of molecules involved in pro-inflammatory and anti ...
Fan Fan Qu +8 more
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Expression of CCL5 (RANTES) and CCR5 in prostate cancer
The Prostate, 2006Expression of the inflammatory chemokine CCL5 (RANTES) by tumor cells is thought to correlate with the progression of several cancers. CCL5 was shown to induce breast cancer cell migration, mediated by the receptor CCR5. A CCR5 antagonist was demonstrated to inhibit experimental breast tumor growth.
Gayle G, Vaday +3 more
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