Results 221 to 230 of about 59,717 (249)

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

A CDK4/6 inhibitor-armed oncolytic adenovirus reverses T cell exhaustion through the Rb-p65-CCL5 pathway and potentiates the antitumor activity of anti-PD-1 or CAR-T therapy in colorectal cancer. [PDF]

Front Immunol
Zhou D, Ran B, Kong L, Liu Y, Xiao L, Chen X, Liu W, Li X, Zhang J, Zhang J, Wu H, Zhang G, Gu X, Zhang W, Wu J, Jiang C.   +15 more
europepmc   +1 more source

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, Volume 13, Issue 52, 18 September 2026.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

CCL5 promotes colon cancer progression via PI3K/AKT signaling and is negatively regulated by STAT1. [PDF]

J Gastrointest Oncol
Zhang X, Zhang X, Luo X, Tian Y, Luo H.
europepmc   +1 more source

CCL5 hiCD4+ T Cells Regulate Macrophage Polarization and Promote Immunotherapy Response in Bladder Cancer. [PDF]

Cancer Res
Luo W, Wang Y, Wang H, Ji YA, Zhang J, Ran Q, Ao Y, Xu J, Zhang J, Cheng X, Wang L, Zhang Y, Zhang J, Ai C, Qin J, Jiang J, Lan W, Liu Q.   +17 more
europepmc   +1 more source

Uncovering the molecular landscape of young-onset diffuse gastric cancer: A relieff-based feature selection analysis on RNA-Seq data. [PDF]

PLoS One
Azni ZK, Borhani MS, Sabouri H, Sajadi SJ, Arjmand MP.   +4 more
europepmc   +1 more source

Triple-armed oncolytic HSV enhances antitumor immunity by remodeling the tumor microenvironment in subcutaneous murine CRC. [PDF]

iScience
Zhang L, Zheng K, Tong W, Chen F, Zhu Y, Han S, Ma Z.   +6 more
europepmc   +1 more source

The intersection of chemokine signaling with the hallmarks of cancer in glioblastoma. [PDF]

J Neurooncol
Chojak R, Turunen JR, Drewes NB, Koutah L, Fares J, Chen RX, Du R, Faisal UH, Kazi HA, Kelley C, Miska J, Heimberger AB, Ahmed AU, Lesniak MS.   +13 more
europepmc   +1 more source

LncRNA AFAP1-AS1 mediates therapy-dependent expression of CCL5, CXCL10 and MMP9 in multiple sclerosis. [PDF]

Biochem Biophys Rep
Hegazy LN, Elkhodiry AA, Rashad MH, Moustafa RR, El Tayebi HM.   +4 more
europepmc   +1 more source

Abstracts from the 2026 Congress of the Scandinavian Society of Anesthesiology and Intensive Care Medicine, Reykjavik, Iceland, June 10–12, 2026

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 9, October 2026.
wiley   +1 more source