Results 71 to 80 of about 4,207 (232)

Next-Generation Sequencing Advances the Genetic Diagnosis of Cerebral Cavernous Malformation (CCM)

Antioxidants, 2022
Cerebral Cavernous Malformation (CCM) is a cerebrovascular disease of genetic origin that predisposes to seizures, focal neurological deficits and fatal intracerebral hemorrhage. It may occur sporadically or in familial forms, segregating as an autosomal
Valerio Benedetti, Rosalia Canzoneri, Andrea Perrelli, Carlo Arduino, Andrea Zonta, Alfredo Brusco, Saverio Francesco Retta   +6 more
doaj   +1 more source

CCM1 and CCM2 variants in patients with cerebral cavernous malformation in an ethnically Chinese population in Taiwan

Scientific Reports, 2019
Cerebral cavernous malformation (CCM) is a vascular malformation characterized by clustered enlarged capillary-like channels in the central nervous system.
Chun-Wei Chang, Peng-Wei Hsu, K. Wei, C. Chang, H. Fung, M. Hsih, W. Hsu, L. Ro, Chen-Nen Chang, Jiun-Jie Wang, Yih-Ru Wu, Sien‐Tsong Chen   +11 more
semanticscholar   +1 more source

Facile Fabrication of Large‐Area Biofunctionalized Metallic Nanostructures for High Performance Affinity Plasmonic Biosensors

Advanced Materials Technologies, Volume 10, Issue 16, August 21, 2025.
A novel approach enables facile and reproducible fabrication of gold nanoparticle arrays with tunable near‐infrared plasmonic properties and enhanced sensing accuracy. Using advanced lithography and ion milling, combined with innovative surface chemistry, the approach minimizes ohmic losses and non‐specific sorption, improving biomolecular detection ...
Dario Cattozzo Mor, Adam Benjamin Plšek, Prasanth Asokan, Van‐Truc Vu, Gizem Aktug, Elena Giordani, Elena Ricciardi, Jiri Perutka, Kamil Önder, Ladislav Fekete, Zdeněk Hubička, Chun‐Jen Huang, Jakub Dostalek   +12 more
wiley   +1 more source

KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell–cell junctions [PDF]

The Journal of Cell Biology, 2007
Cerebral cavernous malformation (CCM), a disease associated with defective endothelial junctions, result from autosomal dominant CCM1 mutations that cause loss of KRIT-1 protein function, though how the loss of KRIT-1 leads to CCM is obscure. KRIT-1 binds to Rap1, a guanosine triphosphatase that maintains the integrity of endothelial junctions.
Glading, Angela, Han, Jaewon, Stockton, Rebecca A, Ginsberg, Mark H   +3 more
openaire   +4 more sources

Programmed Cell Death Protein 10 (PDCD10) Regulates Vesicle Trafficking and Contributes to the Progression of Clear Cell Renal Cell Carcinoma

Journal of Extracellular Vesicles, Volume 14, Issue 6, June 2025.
ABSTRACT Vesicle trafficking is an essential cellular process that plays an important role in tumour progression. Here, we performed a comprehensive transcriptomic and proteomic analysis on 50 clear cell renal cell carcinoma (ccRCC) tumour samples, and the data systematically depicted the alterations in the molecular landscape.
Rui Wang, Tianyu Lin, Yi Liu, Hao Wang, Xinyu Liu, Yihan Dong, Jiaxin Li, Huamao Jiang, Ruibing Chen, Yong Wang, Dan Yue   +10 more
wiley   +1 more source

Regional Response of the NCAR CCM1 to Anomalous Surface Properties

Terrestrial, Atmospheric and Oceanic Sciences, 1997
Sensitivity tests of the National Center for Atmospheric Research (NCAR) Community Climate Model-1 (CCM1) response to surface forcing from sea surface temperature (SST) and soil moisture on precipitation are presented. Four experiments were performed, including a control experiment using climatological SSTs, an experiment with 1988 SSTs, which are ...
Wen-Yih Sun, Michael G. Bosilovich, Jiun-Dar Chern   +2 more
openaire   +1 more source

Assessing simulations of daily temperature and precipitation variability with global climate models for present and enhanced greenhouse climates [PDF]

, 1999
The enhanced greenhouse climates of five different global climate models are examined with reference to the ability of the models to characterize the frequency of extreme events on both a regional and global scale.
Balachova, O., Henderson-Sellers, A., Hoekstra, J., Holbrook, N., Kothalava, Z., McGuffie, K.   +5 more
core   +2 more sources

Cerebral cavernous malformations: Review of the genetic and protein-protein interactions resulting in disease pathogenesis

Frontiers in Surgery, 2016
Mutations in the genes KRIT1, CCM2, and PDCD10 are known to result in the formation of cerebral cavernous malformations (CCMs). CCMs are intracranial lesions comprised of aberrantly enlarged cavernous endothelial channels that can result in cerebral ...
Jacob F. Baranoski, M. Yashar S. Kalani, Joseph M. Zabramski   +2 more
doaj   +1 more source

Correlates of Continued Church Membership Intention: An Empirical Study of Religion in Ghana

Journal for the Scientific Study of Religion, Volume 64, Issue 2, Page 123-147, June 2025.
Abstract This study examines the factors influencing continued church membership intention in Ghana, focusing on the key correlates of this behavior. Using structural equation modeling (SEM) the survey data collected were analyzed. The findings highlight charismatic leadership, religious experience, corporate social responsibility, personal needs ...
Andrews Agya Yalley
wiley   +1 more source

Research on diabatic initialization [PDF]

The objective of this research is to contribute to the improvement of the analyses of irrotational wind and moisture fields in the tropics through advancement in the technique of initialization, incorporating diabatic effects and use of satellite-derived,
Kashara, Akira
core   +5 more sources