Results 21 to 30 of about 3,789 (186)

Cerebral Cavernous Malformation: From Genetics to Pharmacotherapy. [PDF]

Brain Behav
CCM1, CCM2, CCM3, MAP3K3, and PIK3CA genes mediate CCM pathogenesis by regulating the RhoA–ROCK, MAP3K3–KLF2/4, and PIK3CA–AKT–mTOR pathways, affecting processes such as cell migration, intercellular junctions, cell proliferation, inflammation, autophagy, EndMT, angiogenesis, and oxidative stress.
Zhang Z, Deng J, Sun W, Wang Z.
europepmc   +2 more sources

GERM-LINE/SOMATIC DNA COMPARISON IN SPORADIC PATIENTS WITH CEREBRAL CAVERNOUS MALFORMATIONS.

Euromediterranean Biomedical Journal, 2017
Cerebral cavernous malformations (CCMs) are benign tumours that affect brain capillaries. Although many cases remain asymptomatic, their incidence is steadily increasing.
Ivan Anchesi
doaj   +3 more sources

Live or Let Die: CCM2 Provides the Link [PDF]

Neuron, 2009
TrkA receptors are well known for promoting neuronal cell survival. However, in some neuroblastic tumors, TrkA activation can instead induce apoptosis. In this issue of Neuron, Harel et al. identify CCM2 as a mediator of TrkA-dependent cell death, suggesting that CCM2 is a distinctive type of tumor suppressor that modulates tyrosine kinase signaling.
Gruber-Olipitz, Mariella, Segal, Rosalind A.   +1 more
openaire   +5 more sources

CCM2 Expression Parallels That of CCM1 [PDF]

Stroke, 2006
Background and Purpose— Mutations in CCM2 (MGC4607 or malcavernin) cause familial cerebral cavernous malformation (CCM), an autosomal dominant neurovascular disease. Both the function of this molecule and the pathogenesis of the disease remain elusive.
Askin, Seker, Katie L, Pricola, Bulent, Guclu, Ali K, Ozturk, Angeliki, Louvi, Murat, Gunel   +5 more
openaire   +2 more sources

Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations

eLife, 2021
Mosaic inactivation of CCM2 in humans causes cerebral cavernous malformations (CCMs) containing adjacent dilated blood-filled multi-cavernous lesions. We used CRISPR-Cas9 mutagenesis to induce mosaic inactivation of zebrafish ccm2 resulting in a novel ...
Wenqing Li, Virginia Tran, Iftach Shaked, Belinda Xue, Thomas Moore, Rhonda Lightle, David Kleinfeld, Issam A Awad, Mark H Ginsberg   +8 more
doaj   +1 more source

Expression of CCM2 and CCM3 during mouse gonadogenesis [PDF]

Journal of Assisted Reproduction and Genetics, 2015
Three cerebral cavernous malformation (CCM) proteins, CCM1, CCM2, and CCM3, regulate cell-cell adhesion, cell shape and polarity, and most likely cell adhesion to extracellular matrix. Recently, CCM2 and CCM3 are known to be expressed in control and varicocele-induced rat testes, but little is known about these proteins during gonadogenesis.
Yaba, Aylin, Ordueri, Ece, Tanrıöver, Gamze, Şahin, Pınar, Demir, Necdet, Çelik-Özenci, Çiler   +5 more
openaire   +3 more sources

Cerebral vascular malformations: pathogenesis and therapy. [PDF]

MedComm (2020)
CVMs management based on imaging genomics and liquid biopsy. In the future, somatic or de novo germline mutation information could be used to direct neurosurgical and medical management of CVMs. Somatic or germline variants can be acquired from imaging genomics or liquid biopsies preoperatively.
He Q, Huo R, Sun Y, Zheng Z, Xu H, Zhao S, Ni Y, Yu Q, Jiao Y, Zhang W, Zhao J, Cao Y.   +11 more
europepmc   +2 more sources

Using mounting, orientation, and design to improve bat box thermodynamics in a northern temperate environment

Scientific Reports, 2021
Wildlife managers design artificial structures, such as bird houses and bat boxes, to provide alternative nesting and roosting sites that aid wildlife conservation. However, artificial structures for wildlife may not be equally efficient at all sites due
Amélie Fontaine, Anouk Simard, Bryan Dubois, Julien Dutel, Kyle H. Elliott   +4 more
doaj   +1 more source

Differential angiogenesis function of CCM2 and CCM3 in cerebral cavernous malformations [PDF]

Neurosurgical Focus, 2010
Object Loss-of-function mutations in CCM genes are frequently detected in familial cerebral cavernous malformations (CCMs). However, the current functional studies of the CCM genes in vitro have been performed mostly in commercially purchased normal cell lines and the results appeared discrepant.
Zhu, Yuan, Sure, Ulrich, Zhang, Jian-Min, Sandalcioglu, Ibrahim Erol, Miller, Dorothea, Wu, Qun, Xu, Jin-Fang   +6 more
openaire   +3 more sources

Tissue-specific conditionalCCM2knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations [PDF]

Disease Models & Mechanisms, 2009
SUMMARYCerebral cavernous malformations (CCM) are vascular malformations of the brain that lead to cerebral hemorrhages. In 20% of CCM patients, this results from an autosomal dominant condition caused by loss-of-function mutations in one of the three CCM genes.
Gwénola, Boulday, Anne, Blécon, Nathalie, Petit, Fabrice, Chareyre, Luis A, Garcia, Michiko, Niwa-Kawakita, Marco, Giovannini, Elisabeth, Tournier-Lasserve   +7 more
openaire   +2 more sources