Results 31 to 40 of about 2,293 (187)
OMICS Profiling Identifies Signatures of Senescence in Osteogenesis Imperfecta Osteoblasts Counteracted by 4-PBA. [PDF]
J Cell Mol MedABSTRACT Mutations in collagen I are the most common cause of osteogenesis imperfecta (OI), leading to delayed protein folding and structurally abnormal molecules. While some aberrant collagen is secreted into the extracellular matrix (ECM), impairing bone quality, a significant fraction is retained intracellularly, disrupting osteoblast homeostasis. 4‐
Besio R +7 more
europepmc +2 more sources
Deletions in CCM2 Are a Common Cause of Cerebral Cavernous Malformations [PDF]
The American Journal of Human Genetics, 2007 Cerebral cavernous malformations (CCMs) are vascular abnormalities of the brain that can result in a variety of neurological disabilities, including hemorrhagic stroke and seizures. Mutations in the gene KRIT1 are responsible for CCM1, mutations in the gene MGC4607 are responsible for CCM2, and mutations in the gene PDCD10 are responsible for CCM3. DNA
Liquori, Christina L. +6 more
openaire +2 more sources
Scientific Reports, 2021 Wildlife managers design artificial structures, such as bird houses and bat boxes, to provide alternative nesting and roosting sites that aid wildlife conservation. However, artificial structures for wildlife may not be equally efficient at all sites due
Amélie Fontaine +4 more
doaj +1 more source
RivTool European Hydrological Network data - CCM2 Dataset
, 2023 European hydrological network files created based on the CCM2 ...
Gonçalo Duarte +3 more
core +1 more source
Simplex cerebral cavernous malformations with MAP3K3 mutation have distinct clinical characteristics
Frontiers in Neurology, 2022 ObjectivesTo investigate the clinical characteristics of cerebral cavernous malformations (CCMs) with MAP3K3 somatic mutation.MethodsWe performed a retrospective review of our CCMs database between May 2017 and December 2019.
Ran Huo +25 more
doaj +1 more source
Water vapor transport in the NCAR CCM2
Tellus A: Dynamic Meteorology and Oceanography, 1994 The NCAR Community Climate Model, Version 2, uses the spectral transform method for the underlying dry dynamical fluid flow component, and a monotonic, semi-Lagrangian transport algorithm for water vapor specific humidity. The reasons for this choice of 2 different approaches for these different components are reviewed, and the details of the ...
David L. Williamson, Philip J. Rasch
openaire +1 more source
Tissue-specific conditionalCCM2knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations [PDF]
Disease Models & Mechanisms, 2009 SUMMARYCerebral cavernous malformations (CCM) are vascular malformations of the brain that lead to cerebral hemorrhages. In 20% of CCM patients, this results from an autosomal dominant condition caused by loss-of-function mutations in one of the three CCM genes.
Gwénola, Boulday +7 more
openaire +2 more sources
The Role of Immune Infiltration and Oxidative Stress in the Progression of Cerebral Cavernous Malformation. [PDF]
Brain BehavMechanism of rupture hemorrhage in cerebral cavernous malformations. Environmental and immune factors promote the progression of lesions and induce the risk of abnormal formation or rupture of cerebrovascular vessels. Abstract Purpose of Review To review how the immune microenvironment and oxidative stress modulate the initiation, maturation, and ...
Zhu X, Yao Y, Yu T, Xiao X.
europepmc +2 more sources
DIAL measurement of lower tropospheric ozone over Saga (33.24° N, 130.29° E), Japan, and comparison with a chemistry–climate model [PDF]
Atmospheric Measurement Techniques, 2014 We have improved an ozone DIfferential Absorption Lidar (DIAL) system, originally developed in March 2010. The improved DIAL system consists of a Nd:YAG laser and a 2 m Raman cell filled with 8.1 × 105 Pa of CO2 gas which generate four Stokes lines (276,
O. Uchino +18 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2021 Cerebral cavernous malformations are slow-flow thrombi-containing vessels induced by two-step inactivation of the CCM1, CCM2 or CCM3 gene within endothelial cells. They predispose to intracerebral bleedings and focal neurological deficits.
Christiane D. Much +9 more
doaj +1 more source