CCM2 Expression Parallels That of CCM1 [PDF]
Stroke, 2006 Background and Purpose— Mutations in CCM2 (MGC4607 or malcavernin) cause familial cerebral cavernous malformation (CCM), an autosomal dominant neurovascular disease. Both the function of this molecule and the pathogenesis of the disease remain elusive.
Askin, Seker +5 more
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Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations
eLife, 2021 Mosaic inactivation of CCM2 in humans causes cerebral cavernous malformations (CCMs) containing adjacent dilated blood-filled multi-cavernous lesions. We used CRISPR-Cas9 mutagenesis to induce mosaic inactivation of zebrafish ccm2 resulting in a novel ...
Wenqing Li +8 more
doaj +1 more source
Scientific Reports, 2021 Wildlife managers design artificial structures, such as bird houses and bat boxes, to provide alternative nesting and roosting sites that aid wildlife conservation. However, artificial structures for wildlife may not be equally efficient at all sites due
Amélie Fontaine +4 more
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RivTool European Hydrological Network data - CCM2 Dataset
, 2023 European hydrological network files created based on the CCM2 ...
Gonçalo Duarte +3 more
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Water vapor transport in the NCAR CCM2
Tellus A: Dynamic Meteorology and Oceanography, 1994 The NCAR Community Climate Model, Version 2, uses the spectral transform method for the underlying dry dynamical fluid flow component, and a monotonic, semi-Lagrangian transport algorithm for water vapor specific humidity. The reasons for this choice of 2 different approaches for these different components are reviewed, and the details of the ...
David L. Williamson, Philip J. Rasch
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Simplex cerebral cavernous malformations with MAP3K3 mutation have distinct clinical characteristics
Frontiers in Neurology, 2022 ObjectivesTo investigate the clinical characteristics of cerebral cavernous malformations (CCMs) with MAP3K3 somatic mutation.MethodsWe performed a retrospective review of our CCMs database between May 2017 and December 2019.
Ran Huo +25 more
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Tissue-specific conditionalCCM2knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations [PDF]
Disease Models & Mechanisms, 2009 SUMMARYCerebral cavernous malformations (CCM) are vascular malformations of the brain that lead to cerebral hemorrhages. In 20% of CCM patients, this results from an autosomal dominant condition caused by loss-of-function mutations in one of the three CCM genes.
Gwénola, Boulday +7 more
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DIAL measurement of lower tropospheric ozone over Saga (33.24° N, 130.29° E), Japan, and comparison with a chemistry–climate model [PDF]
Atmospheric Measurement Techniques, 2014 We have improved an ozone DIfferential Absorption Lidar (DIAL) system, originally developed in March 2010. The improved DIAL system consists of a Nd:YAG laser and a 2 m Raman cell filled with 8.1 × 105 Pa of CO2 gas which generate four Stokes lines (276,
O. Uchino +18 more
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Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice.
PLoS Biology, 2020 Cerebral cavernous malformations (CCMs) are vascular lesions predominantly developing in the central nervous system (CNS), with no effective treatments other than surgery.
Jia Li +12 more
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Linkage to the CCM2 Locus and Genetic Heterogeneity in Familial Cerebral Cavernous Malformation [PDF]
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2003 ABSTRACT:Background:Cerebral cavernous malformation (CCM) is a form of intracranial vascular disease that may arise sporadically or be dominantly inherited. Linkage studies have revealed genetic heterogeneity among the dominantly inherited forms suggesting the existence of at least three loci called CCM1, CCM2 and CCM3.Methods:In the present study, we ...
Dupré, Nicolas +10 more
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