Results 51 to 60 of about 1,951 (186)
Is Location Everything? Regulation of the Endothelial CCM Signaling Complex
Frontiers in Cardiovascular Medicine, 2022 Recent advances have steadily increased the number of proteins and pathways known to be involved in the development of cerebral cavernous malformation (CCM).
Harsha Swamy, Angela J. Glading
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Clinicoradiologic data of familial cerebral cavernous malformation with age‐related disease burden
Annals of Clinical and Translational Neurology, 2023 Objective Familial cerebral cavernous malformation (FCCM) is an autosomal dominant disease induced by loss‐of‐function mutations in three CCM genes, KRIT1, CCM2, and PDCD10.
Seondeuk Kim +8 more
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The FEBS Journal, Volume 293, Issue 11, Page 3187-3210, June 2026.The authors investigated the effects of various glycan ligands for CLEC10A, a lectin receptor expressed on dendritic cells (DCs). Monocyte‐derived DCs were stimulated with glycan‐conjugated dendrimers in combination with the TLR1/2 ligand Pam3CysK4, and responses were investigated at the mRNA and protein level.
Nadia L. van der Meijs +7 more
wiley +1 more source
JCI Insight, 2023 Loss-of-function mutations in cerebral cavernous malformation (CCM) genes and gain-of-function mutation in the MAP3K3 gene encoding MEKK3 cause CCM. Deficiency of CCM proteins leads to the activation of MEKK3-KLF2/4 signaling, but it is not clear how ...
Xi Yang +13 more
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Estudios genéticos en pacientes y familias con sospecha de enfermedades neurovasculares hereditarias
Kranion, 2023 Introducción: Las enfermedades neurovasculares minoritarias como CADASIL, cavernomatosis múltiple familiar o arteriopatía de moyamoya requieren un abordaje diagnóstico multidisciplinario que incluya un panel genético.
Sara Banda +21 more
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Europe's Ecological Debt: Mapping Freshwater Restoration Needs
Global Change Biology, Volume 32, Issue 3, March 2026.We used data from the Habitats Directive and the Water Framework Directive to assess freshwater‐related restoration needs across Europe using the Composite Indicator of Conservation Status. Freshwater restoration needs are widespread, with over 94% of River Restoration Units (R2U) showing unfavourable conservation status under at least one of the two ...
Gonçalo Duarte +9 more
wiley +1 more source
Simulations of tropospheric joint distributions in the UW θ‐σ model and CCM2 [PDF]
Geophysical Research Letters, 1997 Results are presented for experiments which examine the ability of the University of Wisconsin (UW) hybrid isentropic‐sigma (θ‐σ) and sigma (σ) coordinate models and the NCAR Community Climate Model 2 (CCM2) to transport and conserve the joint distributions of potential temperature (θ) or equivalent potential temperature (θe) and a source‐free inert ...
Tom H. Zapotocny +6 more
openaire +1 more source
, 2005 Cerebral cavernous malformations (CCMs) are sporadically acquired or inherited vascular lesions of the central nervous system consisting of clusters of dilated thin-walled blood vessels that predispose individuals to seizures and stroke.
Abell, Amy N. +3 more
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Mutation prevalence of cerebral cavernous malformation genes in Spanish patients.
PLoS ONE, 2014 ObjectiveTo study the molecular genetic and clinical features of cerebral cavernous malformations (CCM) in a cohort of Spanish patients.MethodsWe analyzed the CCM1, CCM2, and CCM3 genes by MLPA and direct sequencing of exons and intronic boundaries in 94
Rufino Mondéjar +9 more
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Systems-wide analysis unravels the new roles of CCM signal complex (CSC)
Heliyon, 2019 Cerebral cavernous malformations (CCMs) are characterized by abnormally dilated intracranial capillaries that result in increased susceptibility to stroke. Three genes have been identified as causes of CCMs; KRIT1 (CCM1), MGC4607 (CCM2) and PDCD10 (CCM3);
Johnathan Abou-Fadel +4 more
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