The development of a 16S rRNA gene based PCR for the identification of Streptococcus pneumoniae and comparison with four other species specific PCR assays [PDF]
, 2010 Background: Streptococcus pneumoniae is one of the most frequently encountered pathogens in humans but its differentiation from closely related but less pathogenic streptococci remains a challenge.
Nabil Abdullah El Aila +30 more
core +3 more sources
Is Location Everything? Regulation of the Endothelial CCM Signaling Complex
Frontiers in Cardiovascular Medicine, 2022 Recent advances have steadily increased the number of proteins and pathways known to be involved in the development of cerebral cavernous malformation (CCM).
Harsha Swamy, Angela J. Glading
doaj +1 more source
Genetic Insights Into Coronary Microvascular Disease. [PDF]
MicrocirculationABSTRACT Coronary microvascular disease (CMVD) affects the coronary pre‐arterioles, arterioles, and capillaries and can lead to blood supply–demand mismatch and cardiac ischemia. CMVD can present clinically as ischemia or myocardial infarction with no obstructive coronary arteries (INOCA or MINOCA, respectively). Currently, therapeutic options for CMVD
Wayne N +5 more
europepmc +2 more sources
Clinicoradiologic data of familial cerebral cavernous malformation with age‐related disease burden
Annals of Clinical and Translational Neurology, 2023 Objective Familial cerebral cavernous malformation (FCCM) is an autosomal dominant disease induced by loss‐of‐function mutations in three CCM genes, KRIT1, CCM2, and PDCD10.
Seondeuk Kim +8 more
doaj +1 more source
JCI Insight, 2023 Loss-of-function mutations in cerebral cavernous malformation (CCM) genes and gain-of-function mutation in the MAP3K3 gene encoding MEKK3 cause CCM. Deficiency of CCM proteins leads to the activation of MEKK3-KLF2/4 signaling, but it is not clear how ...
Xi Yang +13 more
doaj +1 more source
Estudios genéticos en pacientes y familias con sospecha de enfermedades neurovasculares hereditarias
Kranion, 2023 Introducción: Las enfermedades neurovasculares minoritarias como CADASIL, cavernomatosis múltiple familiar o arteriopatía de moyamoya requieren un abordaje diagnóstico multidisciplinario que incluya un panel genético.
Sara Banda +21 more
doaj +1 more source
Simulations of tropospheric joint distributions in the UW θ‐σ model and CCM2 [PDF]
Geophysical Research Letters, 1997 Results are presented for experiments which examine the ability of the University of Wisconsin (UW) hybrid isentropic‐sigma (θ‐σ) and sigma (σ) coordinate models and the NCAR Community Climate Model 2 (CCM2) to transport and conserve the joint distributions of potential temperature (θ) or equivalent potential temperature (θe) and a source‐free inert ...
Tom H. Zapotocny +6 more
openaire +1 more source
Chemical data assimilation estimates of continental U.S. ozone and nitrogen budgets during the Intercontinental Chemical Transport Experiment-North America [PDF]
, 2007 Global ozone analyses, based on assimilation of stratospheric profile and ozone column measurements, and NOy predictions from the Real-time Air Quality Modeling System (RAQMS) are used to estimate the ozone and NOy budget over the continental United ...
Al-Saadi, J +23 more
core +2 more sources
Systems-wide analysis unravels the new roles of CCM signal complex (CSC)
Heliyon, 2019 Cerebral cavernous malformations (CCMs) are characterized by abnormally dilated intracranial capillaries that result in increased susceptibility to stroke. Three genes have been identified as causes of CCMs; KRIT1 (CCM1), MGC4607 (CCM2) and PDCD10 (CCM3);
Johnathan Abou-Fadel +4 more
doaj +1 more source
The Journal of Clinical Investigation, 2022 The loss function of cerebral cavernous malformation (CCM) genes leads to most CCM lesions characterized by enlarged leaking vascular lesions in the brain.
Zhi Fang +9 more
doaj +1 more source