Results 61 to 70 of about 2,293 (187)

Simulations of tropospheric joint distributions in the UW θ‐σ model and CCM2 [PDF]

Geophysical Research Letters, 1997
Results are presented for experiments which examine the ability of the University of Wisconsin (UW) hybrid isentropic‐sigma (θ‐σ) and sigma (σ) coordinate models and the NCAR Community Climate Model 2 (CCM2) to transport and conserve the joint distributions of potential temperature (θ) or equivalent potential temperature (θe) and a source‐free inert ...
Tom H. Zapotocny, Donald R. Johnson, Todd K. Schaack, Allen J. Lenzen, Fred M. Reames, Philip A. Politowicz, Zhuojian Yuan   +6 more
openaire   +1 more source

NOGOB receptor deficiency increases cerebrovascular permeability and hemorrhage via impairing histone acetylation–mediated CCM1/2 expression

The Journal of Clinical Investigation, 2022
The loss function of cerebral cavernous malformation (CCM) genes leads to most CCM lesions characterized by enlarged leaking vascular lesions in the brain.
Zhi Fang, Xiaoran Sun, Xiang Wang, Ji Ma, Thomas Palaia, Ujala Rana, Benjamin Miao, Louis Ragolia, Wenquan Hu, Qing Robert Miao   +9 more
doaj   +1 more source

The effect of different hydration media on magnesia

Discover Materials, 2021
This paper discusses the rate of hydration of magnesia (CCM1 and CCM2) during the formation of magnesium hydroxide with magnesium acetate and distilled water.
Friedrich von Hoessle, Reham Farid, Mayar Mohamed, Rawia M. Hammouda, Fritz E. Kühn, Ghada Bassioni   +5 more
doaj   +1 more source

Ambient‐Spray Ni–Cu(–O)/Ag Nanowire Transparent Heaters for High‐Temperature Heating and Far‐/Near‐Field EMI Suppression

Advanced Materials Interfaces, Volume 13, Issue 16, 18 August 2026.
A vacuum‐free, ambient‐spray Ni–Cu(–O)/Ag nanowire transparent‐heater platform is realized via conformal junction‐shell engineering and silica–hybrid overcoating, enabling robust high‐temperature heating together with GHz‐band far‐field EMI shielding and near‐field magnetic‐noise attenuation.
Ye Na Heo, Do Il Kim, Hyun Ho Park, Soong Ju Oh, Sang Woo Kim   +4 more
wiley   +1 more source

The mean CCM2 scores for birds assigned to the major Mesozoic avian clades.

, 2012
The mean CCM2 scores for birds assigned to the major Mesozoic avian clades.
Neil Brocklehurst (156277), Jingmai O'Connor (156296), Philip D. Mannion (156289), Paul Upchurch (156283)   +3 more
core   +1 more source

Systems-wide analysis unravels the new roles of CCM signal complex (CSC)

Heliyon, 2019
Cerebral cavernous malformations (CCMs) are characterized by abnormally dilated intracranial capillaries that result in increased susceptibility to stroke. Three genes have been identified as causes of CCMs; KRIT1 (CCM1), MGC4607 (CCM2) and PDCD10 (CCM3);
Johnathan Abou-Fadel, Mariana Vasquez, Brian Grajeda, Cameron Ellis, Jun Zhang   +4 more
doaj   +1 more source

Rapamycin Partially Reverts Cavernoma Endothelial Cell Phenotype and, When Combined With Lapatinib, Ameliorates Chronic Lesions

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT This study investigates the impact of rapamycin and propranolol on cerebral cavernous malformations (CCMs). Employing an unbiased transcriptomic analysis, we aimed to comprehensively elucidate the molecular mechanisms underlying these drug effects.
Mar García‐Colomer, José E. Martínez, Luis Díaz‐Gómez, Miriam Sartages, Eva M. Esquinas‐Román, Cristina Riobello, David Martínez‐Delgado, Diego González‐Pérez, Aurora Gómez‐Durán, Miguel Fidalgo, Marta Varela‐Rey, Celia M. Pombo, Juan Zalvide   +12 more
wiley   +1 more source

The CCM1–CCM2 complex controls complementary functions of ROCK1 and ROCK2 that are required for endothelial integrity [PDF]

Journal of Cell Science, 2018
ABSTRACT Endothelial integrity relies on a mechanical crosstalk between intercellular and cell–matrix interactions. This crosstalk is compromised in hemorrhagic vascular lesions of patients carrying loss-of-function mutations in cerebral cavernous malformation (CCM) genes.
Lisowska, Justyna, Rödel, Claudia, Manet, Sandra, Miroshnikova, Yekaterina, Boyault, Cyril, Planus, Emmanuelle, de Mets, Richard, Lee, Hsiao-Hui, Destaing, Olivier, Mertani, Hichem, Boulday, Gweńola, Tournier-Lasserve, Elisabeth, Balland, Martial, Abdelilah-Seyfried, Salim, Albiges-Rizo, Corinne, Faurobert, Eva   +15 more
openaire   +4 more sources

Mutation prevalence of cerebral cavernous malformation genes in Spanish patients.

PLoS ONE, 2014
ObjectiveTo study the molecular genetic and clinical features of cerebral cavernous malformations (CCM) in a cohort of Spanish patients.MethodsWe analyzed the CCM1, CCM2, and CCM3 genes by MLPA and direct sequencing of exons and intronic boundaries in 94
Rufino Mondéjar, Francisca Solano, Rocío Rubio, Mercedes Delgado, Angel Pérez-Sempere, Antonio González-Meneses, Teresa Vendrell, Guillermo Izquierdo, Amalia Martinez-Mir, Miguel Lucas   +9 more
doaj   +1 more source

Deep-Learning Uncovers certain CCM Isoforms as Transcription Factors

Frontiers in Bioscience-Landmark
Background: Cerebral Cavernous Malformations (CCMs) are brain vascular abnormalities associated with an increased risk of hemorrhagic strokes. Familial CCMs result from autosomal dominant inheritance involving three genes: KRIT1 (CCM1), MGC4607 (CCM2 ...
Jacob Croft, Liyuan Gao, Victor Sheng, Jun Zhang   +3 more
doaj   +1 more source